Characterization and quenching correction for a 2D real time radioluminescent system in therapeutic proton and carbon charged beams

Nascimento, L.F.; Leblans, Paul; Heyden, Brent van der; Akselrod, M.S.; Goossens, Jo; Verellen, Dirk; Kodaira, Satoshi

doi:10.1016/j.sna.2022.113781

Cited by 6 publications

(5 citation statements)

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“…This effect was previously observed in other studies [ 38 , 41 , 56 ]. Figure 3 suggests a dependency on crystal size and the deposition of energy, similar to those observed for irradiations with other beam types, such as 6 MV photons [ 38 ] and heavily charged particles [ 30 , 41 ]. Although identifying the exact mechanisms explaining the differences between crystal sizes needs further analysis, we believe this effect comes from the competition between the immediate recombination of charge carriers and charge trapping.…”

Section: Discussionsupporting

confidence: 63%

“…There is also a better agreement for lower LET beams (i.e., 230 MeV protons) than for the higher LET beams (290 MeV/u). The link between quenching and crystal size was observed previously [ 30 , 41 ], where probes with ‘38 μm’ were compared with ‘Single Crystal’. We further studied crystal size dependence with LET by adding an extra (smaller) crystal size (‘4 μm’) and four extra beams.…”

Section: Discussionmentioning

confidence: 64%

“…Our proposed quenching correction factor η [ 30 ] is the sum of the fluence-weighted quenching corrections η i for each particle type (primary and fragment) for specific LET ranges in water.

where

is the percentage contribution in fluence of particle “ i ” at position “ d ”, multiplied by the correction factor corresponding to the LET at depth d .…”

Section: Methodsmentioning

confidence: 99%

“…The novelty of our method is to include the contribution from fragments generated along the Bragg curves by proposing a novel general expression for quenching correction factors. In a previous attempt to correct the response to proton and carbon-charged particle beams in 2D, real time RL films, we observed that a better agreement could be reached by including more fragments in our calculations [ 30 ].…”

Section: Introductionmentioning

confidence: 94%

“…The aforementioned method [ 30 ] is now applied on three types of RL optical fibre probes, composed of Al 2 O 3 :C, in five therapeutic charged particle beams: 160 and 230 MeV protons, 150 MeV/u helium ions, and 290 and 400 MeV/u carbon ions. For all the optical fibre probe types, the quenching-corrected doses along the Bragg curves resulted in substantial improvement when compared to uncorrected data.…”

Section: Introductionmentioning

confidence: 99%

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Characterisation and Quenching Correction for an Al2O3:C Optical Fibre Real Time System in Therapeutic Proton, Helium, and Carbon-Charged Beams

Nascimento

Leblans

Heyden

et al. 2022

Sensors

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Real time radioluminescence fibre-based detectors were investigated for application in proton, helium, and carbon therapy dosimetry. The Al2O3:C probes are made of one single crystal (1 mm) and two droplets of micro powder in two sizes (38 μm and 4 μm) mixed with a water-equivalent binder. The fibres were irradiated behind different thicknesses of solid slabs, and the Bragg curves presented a quenching effect attributed to the nonlinear response of the radioluminescence (RL) signal as a function of linear energy transfer (LET). Experimental data and Monte Carlo simulations were utilised to acquire a quenching correction method, adapted from Birks’ formulation, to restore the linear dose–response for particle therapy beams. The method for quenching correction was applied and yielded the best results for the ‘4 μm’ optical fibre probe, with an agreement at the Bragg peak of 1.4% (160 MeV), and 1.5% (230 MeV) for proton-charged particles; 2.4% (150 MeV/u) for helium-charged particles and of 4.8% (290 MeV/u) and 2.9% (400 MeV/u) for the carbon-charged particles. The most substantial deviations for the ‘4 μm’ optical fibre probe were found at the falloff regions, with ~3% (protons), ~5% (helium) and 6% (carbon).

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 64%

“…Our proposed quenching correction factor η [ 30 ] is the sum of the fluence-weighted quenching corrections η i for each particle type (primary and fragment) for specific LET ranges in water.

where

is the percentage contribution in fluence of particle “ i ” at position “ d ”, multiplied by the correction factor corresponding to the LET at depth d .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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