Characterization and resolution of reversed phase HPLC chromatography failure attributed to sulfobutylether-β-cyclodextrin in a pharmaceutical sample preparation

Ngim, Kenley K.; Gu, Zhengtian; Catalano, Thomas

doi:10.1016/j.jpba.2008.12.015

Cited by 6 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data showed that the retention times of both SN-38 L and SN-38 C fitted those of cyclodextrin-free SN-38 and suggested that HPBCD complexes underwent decomplexation upon the addition of methanol and mobile phase for HPLC analysis. At the same time, care should be taken in new applications with other drugs because specific cyclodextrins interfere with columns during drug analysis (33).…”

Section: Discussionmentioning

confidence: 99%

Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts

et al. 2015

View full text Add to dashboard Cite

show abstract

γ-Cyclodextrin

Saokham

Loftsson

2017

International Journal of Pharmaceutics

138

View full text Add to dashboard Cite

γ-Cyclodextrin (γCD) is a cyclic oligosaccharide formed by bacterial digestion of starch and used as solubilizing agent and stabilizer in a variety of pharmaceutical and food products. γCD is a large (molecular weight 1297Da) hydrophilic molecule that does not readily permeate biological membranes and is rapidly digested by bacteria in the gastrointestinal tract. In humans γCD is metabolized by α-amylase that is found in, for example, saliva, bile fluid and tears. Thus, bioavailability of γCD is negligible. Also, γCD is readily excreted unchanged in the urine after parenteral administration. Like other cyclodextrins, γCD can form water-soluble inclusion complexes with many poorly-soluble compounds. In comparison with the natural αCD and βCD, γCD has the largest hydrophobic cavity, highest water solubility and the most favorable toxicological profile. The focus of this review is production, physiochemical properties, pharmacokinetics, toxicity and applications of γCD and its derivatives. Also, the aggregation behavior of γCD in aqueous media is discussed.

show abstract

Separation performance and recognition mechanism of mono(6-deoxy-imino)-β-cyclodextrins chiral stationary phases in high-performance liquid chromatography

Zhou

Chen

et al. 2010

Talanta

View full text Add to dashboard Cite

Characterization and resolution of reversed phase HPLC chromatography failure attributed to sulfobutylether-β-cyclodextrin in a pharmaceutical sample preparation

Cited by 6 publications

References 19 publications

Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts

Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts

γ-Cyclodextrin

Separation performance and recognition mechanism of mono(6-deoxy-imino)-β-cyclodextrins chiral stationary phases in high-performance liquid chromatography

Contact Info

Product

Resources

About