Characterization and simulation of peristaltic micropumps

Busek, Mathias; Nötzel, M.; Polk, Christoph; Sonntag, Frank

doi:10.5194/jsss-2-165-2013

Cited by 16 publications

(20 citation statements)

References 14 publications

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“…Magnetic and nanoscale parameter ranges are consistent with the suggestions of Arruebo et al 58 and Funk et al 59 Electrokinetic parameters are based on the recommendations of Min et al 60 and Bourouina et al 61 and apply to micropump electro-osmotic designs. Peristaltic wave characteristics prescribed are consistent with the data and dimensionless parameter ranges specified in Bourouina et al 61 and Busek et al 62 All physiological fluid dynamic and mass diffusion characteristics are based on data provided in the excellent treatise by Lightfoot et al 63 Finally, all thermal parameters are consistent with those adopted in magnetic thermal therapy applications in Moros. 64 The parameters utilized in the present article, are, therefore, as realistic as possible for practical biomedical and bioenergetics applications.…”

Section: Computational Results and Physical Interpretationsupporting

confidence: 68%

Thermal slip and radiative heat transfer effects on electro‐osmotic magnetonanoliquid peristaltic propulsion through a microchannel

Prakash¹,

Siva

Tripathi

et al. 2019

Heat Trans. Asian Res.

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A mathematical study is described to examine the concurrent influence of thermal radiation and thermal wall slip on the dissipative magnetohydrodynamic electro‐osmotic peristaltic propulsion of a viscous nanoliquid in an asymmetric microchannel under the action of an axial electric field and transverse magnetic field. Convective boundary conditions are incorporated in the model and the case of forced convection is studied, that is, thermal and species (nanoparticle volume fraction) buoyancy forces neglected. The heat source and sink effects are also included and the diffusion flux approximation is employed for radiative heat transfer. The transport model comprises the continuity, momentum, energy, nanoparticle volume fraction, and electric potential equations with appropriate boundary conditions. These are simplified by negating the inertial forces and invoking the Debye–Hückel linearization. The resulting governing equations are reduced into a system of nondimensional simultaneous ordinary differential equations, which are solved analytically. Numerical evaluation is conducted with symbolic software (MATLAB). The impact of different control parameters (Hartmann number, electro‐osmosis parameter, slip parameter, Helmholtz–Smoluchowski velocity, Biot numbers, Brinkman number, thermal radiation, and Prandtl number) on the heat, mass, and momentum characteristics (velocity, temperature, Nusselt number, etc) are presented graphically. Increasing Brinkman number is found to elevate temperature magnitudes. For positive Helmholtz–Smoluchowski velocity (reverse axial electrical field) temperature is strongly reduced, whereas for negative Helmholtz–Smoluchowski velocity (aligned axial electrical field), it is significantly elevated. With increasing thermal slip, nanoparticle volume fraction is also increased. Heat source elevates temperatures, whereas heat sink depresses them, across the microchannel span. Conversely, heat sink elevates nanoparticle volume fraction, whereas heat source decreases it. Increasing Hartmann (magnetic) parameter and Prandtl number enhance the nanoparticle volume fraction. Furthermore, with increasing radiation parameter, the Nusselt number is reduced at the extremities of the microchannel, whereas it is elevated at intermediate distances. The results reported provide a good insight into biomimetic energy systems exploiting electromagnetics and nanotechnology, and, furthermore, they furnish a useful benchmark for experimental and more advanced computational multiphysics simulations.

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Section: Computational Results and Physical Interpretationsupporting

confidence: 68%

Thermal slip and radiative heat transfer effects on electro‐osmotic magnetonanoliquid peristaltic propulsion through a microchannel

Prakash¹,

Siva

Tripathi

et al. 2019

Heat Trans. Asian Res.

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“…On-chip pumps have been one of the most challenging hurdles. Electromechanical or gas pressure controlled peristaltic micropumps are integrated into the microchannel circuits for a maximum of autonomous operation and to ensure low perfusion rates for circulation and exchange of culture media (Busek et al, 2013; Schimek et al, 2013). Miniaturized sensors based on thin-film or microbead-based fluorescent indicators (Liebsch et al, 2000; Schmälzlin et al, 2005) are increasingly implemented into MPS to monitor and control dO2, dCO2 or pH.…”

Section: Microphysiological Systems – An Expanding Toolbox For Hazmentioning

confidence: 99%

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx¹,

Andersson

Bahinski

et al. 2016

ALTEX

193

229

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Summary The recent advent of microphysiological systems – microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro – is envisaged to enable a global paradigm shift in drug development. An extraordinary US governmental initiative and various dedicated research programs in Europe and Asia have led recently to the first cutting-edge achievements of human single-organ and multi-organ engineering based on microphysiological systems. The expectation is that test systems established on this basis would model various disease stages, and predict toxicity, immunogenicity, ADME profiles and treatment efficacy prior to clinical testing. Consequently, this technology could significantly affect the way drug substances are developed in the future. Furthermore, microphysiological system-based assays may revolutionize our current global programs of prioritization of hazard characterization for any new substances to be used, for example, in agriculture, food, ecosystems or cosmetics, thus, replacing laboratory animal models used currently. Thirty-five experts from academia, industry and regulatory bodies present here the results of an intensive workshop (held in June 2015, Berlin, Germany). They review the status quo of microphysiological systems available today against industry needs, and assess the broad variety of approaches with fit-for-purpose potential in the drug development cycle. Feasible technical solutions to reach the next levels of human biology in vitro are proposed. Furthermore, key organ-on-a-chip case studies, as well as various national and international programs are highlighted. Finally, a roadmap into the future is outlined, to allow for more predictive and regulatory-accepted substance testing on a global scale.

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“…For that purpose the Fraunhofer IWS developed a lab-on-a-chip platform for perfused cell-based assays during the last years, which includes different micropumps [5], valves, channels, reservoirs, and customized cell culture modules. This technology is already implemented for the characterization of different human cell cultures and organoids, like skin [6], liver [7,8], endothelium [9], hair follicle [10], intestine [7] and kidney [6].…”

Section: Introductionmentioning

confidence: 99%

Universal lab-on-a-chip platform for complex, perfused 3D cell cultures

et al. 2016

Self Cite

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The miniaturization, rapid prototyping and automation of lab-on-a-chip technology play nowadays a very important role. Lab-on-a-chip technology is successfully implemented not only for environmental analysis and medical diagnostics, but also as replacement of animals used for the testing of substances in the pharmaceutical and cosmetics industries. For that purpose the Fraunhofer IWS and partners developed a lab-on-a-chip platform for perfused cell-based assays in the last years, which includes different micropumps, valves, channels, reservoirs and customized cell culture modules. This technology is already implemented for the characterization of different human cell cultures and organoids, like skin, liver, endothelium, hair follicle and nephron. The advanced universal lab-on-a-chip platform for complex, perfused 3D cell cultures is divided into a multilayer basic chip with integrated micropump and application-specific 3D printed cell culture modules. Moreover a technology for surface modification of the printed cell culture modules by laser micro structuring and a complex and flexibly programmable controlling device based on an embedded Linux system was developed. A universal lab-on-a-chip platform with an optional oxygenator and a cell culture module for cubic scaffolds as well as first cell culture experiments within the cell culture device will be presented. The module is designed for direct interaction with robotic dispenser systems. This offers the opportunity to combine direct organ printing of cells and scaffolds with the microfluidic cell culture module. The characterization of the developed system was done by means of Micro-Particle Image Velocimetry (μPIV) and an optical oxygen measuring system

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Characterization and simulation of peristaltic micropumps

Cited by 16 publications

References 14 publications

Thermal slip and radiative heat transfer effects on electro‐osmotic magnetonanoliquid peristaltic propulsion through a microchannel

Thermal slip and radiative heat transfer effects on electro‐osmotic magnetonanoliquid peristaltic propulsion through a microchannel

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Universal lab-on-a-chip platform for complex, perfused 3D cell cultures

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