Characterization and Susceptibility Pattern of Candida Isolates From Hiv - Seropositive Patients in a Tertiary Care Hospital

Sastry, Apurba; K, Sandhya Bhat; Sastry, Anand; M.S, Kumudavathi

doi:10.14260/jemds/92

Cited by 2 publications

(1 citation statement)

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“…Candida albicans showed resistant pattern to Ketoconazole and C. glabrata to Clotrimazole. The observations made in this study was similar to the one by Sastry et al [39] which showed Candida dubliniensis resistance to Fluconazole, while other species of Candida were sensitive to Itraconazole. From the results of this study, it can be suggested that Itraconazole and Amphotericin B were found to be most effective drugs of therapy for treatment of C. glabrata.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of yeast in diabetic foot infections

Sugandhi

Prasanth

2016

Int J Diabetes Dev Ctries

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Diabetic foot infections are a serious threat which cause a long term of hospitalization of diabetes patients and lead to amputations. Hence, prompt diagnosis is an important criterion in the treatment of these infections. This study was carried out to determine the prevalence of yeast in diabetic foot infections. The pus samples were collected from patients presenting with diabetic foot ulcer and processed for microbiological investigation. The patients investigated comprised of 82 males and 78 females. Most of the patients were grade I ulcers followed by grade II ulcers. Out of 160 samples, 138 samples were culture positive, in which yeast isolate Candida glabrata was the predominant isolate followed by Candida albicans, Candida dubliniensis, Candida krusei and Candida tropicalis. C. albicans and C. dubliniensis were differentiated by using tobacco agar due to the presence of hyphal fringes. The methylene blue sabouraud dextrose agar and corn meal agar were also used to differentiate C. albicans from non albicans. The antifungal susceptibility pattern showed 29 % of C. albicans was sensitive to Amphotericin B and Clotrimazole, while 75 % of C. glabrata was sensitive to Amphotericin B, Ketoconazole and Itraconazole. C. dublinensis and C. albicans showed the highest percentage of resistant to Ketoconazole, Fluconazole, Nystatin and Itraconazole. Thus, the results indicating that effective alternate drug of choice are required and the proper selection of antifungal agents will play an important role for the treatment of fungal foot infections. This study will also add substantial knowledge of yeast as one of the pathogenic organisms in diabetic foot infections.

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Section: Discussionsupporting

confidence: 91%