Characterization and Treatment of Recurrent Bacterial Vaginosis

Faught, Brooke; Reyes, Sergio

doi:10.1089/jwh.2018.7383

Cited by 63 publications

(42 citation statements)

References 85 publications

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“…This finding indicates that the treatment of plasmaactivated water from our device in the patients with vaginitis exhibited a similar therapeutic effect as it did in the control patients treated with betadine antiseptic. However, the therapeutic effects shown in both the control and experimental groups were partially rediscovered on VISIT 4, which is a common symptom of recurrent bacterial vaginosis [17]. Therefore, several repetitive treatments of plasma-activated water are likely required to protect against the recurrence of vaginitis.…”

Section: Clinical Design and Results To Assess The Safety And Effectimentioning

confidence: 99%

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Hwang¹,

Jeon²,

Wang³

et al. 2020

Plasma

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Bacterial vaginosis is a common female disease caused by a vaginal infection due to an overgrowth of bacteria that naturally live in the vaginal tract. Bacterial vaginosis has frequently been treated with the oral or vaginal administration of antibiotics and topical disinfectants. However, hygienic application of topical treatment deep in the vagina remains difficult. Herein, we introduce a novel vaginal cleaning device using plasma-activated water generated from supplied water. Remarkably, plasma source generation at atmospheric pressure is well known to eradicate bacterial infection through the generation of free radicals and/or chlorine chemicals with antimicrobial activity. The device was designed to alleviate a bacterial infection by spraying plasma-activated water generated from a cleaning solution container with plasma modules. The spray nozzle contains both a clean outlet and a suction outlet to spray and recover the plasma water, respectively, and is connected to a disposable silicone tube. The other nozzle, which has a laser light and air pump, can perform a second sterilization and dry the vagina after washing. Free chlorine chemicals with antibacterial activity were detected in the plasma-activated water by the device. Clinical application in patients with bacterial vaginosis confirmed the stability and effectiveness of our device. Therefore, these results show a novel clinical application of atmospheric pressure plasma to medical field as a plasma medicine.

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Section: Clinical Design and Results To Assess The Safety And Effectimentioning

confidence: 99%

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Hwang¹,

Jeon²,

Wang³

et al. 2020

Plasma

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“…Nevertheless, the underlying mechanisms of recurrent etiology of BV are not fully understood. 30 A substantial percentage of women have asymptomatic BV (ie, Nugent score between 4 and 10 but no symptoms). Some patients may also have 3 of 4 symptoms but do not report symptoms on direct questioning.…”

Section: Bacterial Vaginosis Diagnosis and Treatment Of Bacterial Vagmentioning

confidence: 99%

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Ravel

Moreno

Simón

2021

American Journal of Obstetrics and Gynecology

202

112

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Bacterial vaginosis, pelvic inflammatory disease, and endometritis are infections of the genital tract that can lead to many adverse health outcomes, including infertility. Bacterial vaginosis is characterized by a lower prevalence of lactobacilli and a higher prevalence of anaerobic bacteria, including Gardnerella vaginalis, Megasphaera spp., and Atopobium vaginae. Endometritis and pelvic inflammatory disease are caused by the ascension of pathogenic bacteria to the uterus, although the mechanisms by which they do so are unclear. Bacterial vaginosis, chronic endometritis, and pelvic inflammatory disease have been linked to infertility in retrospective and prospective trials. Similarly, the causes of bacterial vaginosis and endometritis-related infertility are likely multifactorial and stem from inflammation, immune targeting of sperm antigens, the presence of bacterial toxins, and increased risk of sexually transmitted infections. Diagnosis and treatment of bacterial vaginosis, chronic endometritis, and pelvic inflammatory disease before attempting conception may be important components of preconceptional care for symptomatic women to improve outcomes of natural and assisted reproduction.

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“…Хоча протягом багатьох років одним із препаратів вибору для патогенетично обумовленого лікування бактеріального вагінозу залишається кліндаміцин [14,19,21,43], проте дослідження його фармакокінетики при місцевому введення у формі супозиторіїв демонструє широкий діапазон значень фармакокінетичних показників. На нашу думку, причиною даного феномену можуть бути певні ендогенні чинники, які варіюють у різних жінок.…”

Section: вступunclassified

“…Протягом багатьох років одним із препаратів вибору для патогенетично обумовленого лікування бактеріального вагінозу залишається кліндаміцин [14,19,21,43].…”

Section: бактеріальній вагінозunclassified

Intravaginal use of clindamycin phosphate in therapy of bacterial vaginosis: peculiarities of pharmacokinetics depending on the level of hydrogen sulfide in the organism (literature review)

Гребенюк¹,

Таран²,

Назарчук³

2020

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The article provides an overview of modern literature data on the problems of bacterial vaginosis, its therapy with clindamycin, the pharmacokinetics of this pharmacological drug, and the potential effect of the background level of hydrogen sulfide in the body on the pharmacokinetics of drugs. From PubMed, ScienceDirect, UpToDate databases, 50 sources were selected that met the conditions of the query: the latest publications (for the last 5 years), or the latest publications on this issue (regardless of age). The wide and diverse influence of endogenous hydrogen sulfide on the course of biochemical and physiological processes in the body prompts the study of its potential modulating effect on the pharmacological properties of drugs. A preclinical study of the pharmacokinetics and pharmacodynamics of drugs (in particular, clindamycin) will further optimize therapeutic regimens taking into account the level of hydrogen sulfide in the body, as well as create the preconditions for the development of new effective pharmaceutical compositions of antibiotics and hydrogen sulfide donors.

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Characterization and Treatment of Recurrent Bacterial Vaginosis

Cited by 63 publications

References 85 publications

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Intravaginal use of clindamycin phosphate in therapy of bacterial vaginosis: peculiarities of pharmacokinetics depending on the level of hydrogen sulfide in the organism (literature review)

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