Characterization, dynamic swelling behaviour and solute transport in cationic networks with applications to the development of swelling-controlled release systems

Hariharan, D.; Peppas, Nikolaos A.

doi:10.1016/0032-3861(96)81610-7

Cited by 94 publications

(60 citation statements)

References 14 publications

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“…Equation 1 proposed by Hariharan and Peppas 30 as showing below is employed to describe the water uptake and diffusion from hydrogels.…”

Section: Dynamic Analyses On Hydrogel's Swelling Behaviormentioning

confidence: 99%

“…As shown in Table III, the samples A, B, and C was prepared using the same molar ratio (b-CD : AAc ¼ 1 : 10) at different reaction temperatures for 37 h. The results indicate that their ratios of T % 1718 /T % 2938 increase with the increase in temperature, because there exists a marked variation for ratios of T % 1718 /T % 2938 at 30-40 C compared to the ratios at [20][21][22][23][24][25][26][27][28][29][30] C. In addition, it is found that, within 7-37 hours, the ratios of T % 1718 / T % 2938 for samples D, E, F, and B increase gradually with the increase in reaction time, wheseas the ratios of T % 1718 /T % 2938 for samples G, H, F, and I increase following the increase in the molar ratio of b-CD and AAc.…”

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confidence: 92%

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Synthesis and properties of hydrogels of poly(acrylic‐co‐acroloyl β‐cyclodextrin)

Huang¹,

Fan²

2009

J of Applied Polymer Sci

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Novel acrylic monomers (b-CD-A and b-CD-6-EA) containing b-cyclodextrin (b-CD) with different extent of substitution were prepared by using dicyclohexylcarbodiimide (DCC) as a condensation agent at room temperature. Two kinds of functional hydrogels were also synthesized by copolymerization of b-CD-A and b-CD-6-EA with acrylic acid (AAc) using a redox initiator system in aqueous solution. The nuclear magnetic resonance ( 1 H NMR), infrared spectroscopy (IR), thermogravimetric analysis (TGA) were employed to character the molecular structures of b-CD modified monomers and their copolymers. The swelling experiments indicate that the hydrogels with different equilibrium swelling ratio (ESR) possess obvious pH-sensitivity and distinct dynamic swelling behavior. Using an anti-cancer drug, chlorambucil (CHL), able to form complexes with b-CD in water, as a model compound, the controlled drug release behaviors of these hydrogels were investigated. The release behavior of CHL from two kinds of hydrogels synthesized reveals that the release rate of CHL can be effectively controlled by pH values, cross-linking density, and b-CD content. In addition, it is found that the b-CD with the proper frame and concentration can increase release efficiency of CHL from the hydrogels.

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“…Equation 1 proposed by Hariharan and Peppas 30 as showing below is employed to describe the water uptake and diffusion from hydrogels.…”

Section: Dynamic Analyses On Hydrogel's Swelling Behaviormentioning

confidence: 99%

mentioning

confidence: 92%

Synthesis and properties of hydrogels of poly(acrylic‐co‐acroloyl β‐cyclodextrin)

Huang¹,

Fan²

2009

J of Applied Polymer Sci

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“…Hariharan & Peppas (1996) studied dynamic and equilibrium swelling for a poly(diethylaminoethyl methacrylate-co-hydroxyethyl methacrylate) (poly(DEAEM-co-HEMA)), poly(diethylaminoethyl acrylate-co-hydroxyethyl methacrylate) (poly(DEAEAco-HEMA), and also poly(methacrylaminopropyl ammonium chloride-co-hydroxyethyl methacrylate) (poly(MAPTACco-HEMA)). They were able to demonstrate that poly(DEAEAco-HEMA) showed no water sorption at pH 8, while the gels were able to uptake more than 10-times the weight of the collapsed gel at pH 3.…”

Section: Implicit Closed-loop Controlmentioning

confidence: 99%

The future of open- and closed-loop insulin delivery systems

Farmer

Edgar

Peppas

2008

Journal of Pharmacy and Pharmacology

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We have analysed several aspects of insulin-dependent diabetes mellitus, including the glucose metabolic system, diabetes complications, and previous and ongoing research aimed at controlling glucose in diabetic patients. An expert review of various models and control algorithms developed for the glucose homeostasis system is presented, along with an analysis of research towards the development of a polymeric insulin infusion system. Recommendations for future directions in creating a true closed-loop glucose control system are presented, including the development of multivariable models and control systems to more accurately describe and control the multi-metabolite, multi-hormonal system, as well as in-vivo assessments of implicit closed-loop control systems.

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“…It is swell or shrink according to changes in environmental pH and temperature. This phenomena is due to polymer protonation (Hariharan and Peppas, 1996).…”

Section: Introductionmentioning

confidence: 99%

Silan/biopolymer microgels for functionalization of cotton fabric: dual responsive pH and temperature and antibacterial properties

Mohamed¹

2017

J App Pharm Sci

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Biopolymer/chitosan/silan composite wassynthesized in four form by conjugating of chitosan with different biopolymer compounds namely, β-Cyclodextrin (β-CD), Arabic gum, Guar gum and Pullulan in presence of 3-glycidoxypropyltrimethoxysilan (GPTMS) as a cross-linker. Characterisation of the prepared composites has been done through some measurements. FT-IR confirmed the chemical reactions between biopolymers, chitosan andGPTMS.TEM and particle size confirm that, the particles are in small size ranged from 20 -200 µm and have porous structure. Textural properties of the prepared composites were studied and provide that, the microgel with pullulan have the best texture properties than other gels, and gel with guar gum have a worst texture properties. Studding the pH effect found that, the microgels particle size was changing with increasing/decreasing the temperature. The flow properties of the chitosan based microgels at different concentrations and different temperatures were also determined. Treated fabrics with chitosan-based microgels were characterized for their morphological structure, antibacterial properties, water uptake for untreated and treated fabrics at different pHs and temperatures and it is confirmed that, the prepared composites impart a hydrophobicity property to the cotton fabrics.

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Characterization, dynamic swelling behaviour and solute transport in cationic networks with applications to the development of swelling-controlled release systems

Cited by 94 publications

References 14 publications

Synthesis and properties of hydrogels of poly(acrylic‐co‐acroloyl β‐cyclodextrin)

Synthesis and properties of hydrogels of poly(acrylic‐co‐acroloyl β‐cyclodextrin)

The future of open- and closed-loop insulin delivery systems

Silan/biopolymer microgels for functionalization of cotton fabric: dual responsive pH and temperature and antibacterial properties

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