Characterization, evolution and expression analysis of Toll-like receptor 7 (TLR7) in turbot (Scophthalmus maximus L.)

Wang, Beibei; Liu, Xiaoli; Zhao, Jing; Cao, Min; Yu, Zhouxin; Fu, Qiang; Tan, Fenghua; Li, Chao

doi:10.1016/j.fsi.2022.04.035

Cited by 6 publications

(2 citation statements)

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“…This variation in expression changes of TLR3 might be due to differences in TLR3-mediated inflammatory responses among different immune organs, further hinting that apart from their recognition of dsRNA, TLR3 was also engaged in fish immune responses to bacterial infections. SmTLR7 was markedly down-regulated in the gill and intestine of turbot (Scophthalmus maximus) following infection with both E. tarda and Vibrio anguillarum (Wang et al, 2022). After A. hydrophila infection, the expression level of MaTLR14 was upregulated in the liver, spleen, foregut, and hindgut of Asian swamp eels (Monopterus albus) (Liu et al, 2022b).…”

Section: Discussionmentioning

confidence: 99%

The identification of toll-like receptor genes in large yellow croaker (Larimichthys crocea): provides insights into its environmental adaptation to biological and abiotic stresses

Yao,

Miao,

Sun

et al. 2024

Front. Mar. Sci.

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Large yellow croaker (Larimichthys crocea), the most developing fish of China, suffering from both biotic and abiotic stressors. A genome-wide study was performed for the first time to investigate the roles of Toll-like receptor genes in large yellow croaker (LcTLRs) working in hypoxia response and Aeromonas hydrophila infection. 12 TLR genes were identified and annotated, and phylogenetic tree, analysis of structure and motifs demonstrated that TLRs were highly conserved. To further investigate the LcTLRs under environmental stress, expression pattern analysis of hypoxic response and Aeromonas hydrophila infection revealed that there were nine and six members of LcTLRs showing significant differential expression, indicating that they were concerned in hypoxia stress and disease responses. Meanwhile, their expression levels were validated utilizing qPCR. Taken together, a greater appreciation and understanding of TLRs function in the reaction to biotic and abiotic stress would ultimately lead to more efficiently environmental adaptation in large yellow croaker.

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Section: Discussionmentioning

confidence: 99%