Characterization, Expression, and Functional Analysis of the Northern Snakehead (Channa argus) Hepcidin

Liao, Guowei; Wang, Shulan; Wang, Zimo; Zhang, Chaonan; Li, Zicong; Yang, Huirong; Zhou, Aiguo; Xie, Shaolin; Fan, Lanfen; Wang, Meifang; Zou, Jixing; Zeng, Fang

doi:10.1007/s12602-023-10195-y

Probiotics & Antimicro. Prot.

2023

DOI: 10.1007/s12602-023-10195-y

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Characterization, Expression, and Functional Analysis of the Northern Snakehead (Channa argus) Hepcidin

Guowei Liao,

Shulan Wang,

Zimo Wang

et al.

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2024

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Cited by 2 publications

References 61 publications

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Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR/NFκB pathway

Wang,

Chen,

Song

et al. 2024

Fish & Shellfish Immunology

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Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR/NFκB pathway

Wang,

Chen,

Song

et al. 2024

Fish & Shellfish Immunology

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Transcriptomic analysis of liver immune response in Chinese spiny frog (Quasipaa spinosa) infected with Proteus mirabilis

Liu,

Tao,

Chen

et al. 2024

Open Life Sciences

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The expansion of Chinese spiny frog (Quasipaa spinosa) aquaculture has increased the prevalence and severity of diseases such as “skin rot” disease, which is triggered by harmful bacteria. Previous studies have mainly focused on pathogen identification and vaccine development. However, frog immune responses following pathogenic bacterial infection have hardly been investigated. We thus examined the immune response of Chinese spiny frog to skin rot disease caused by Proteus mirabilis. The liver transcriptomes of Chinese spiny frog infected with P. mirabilis were sequenced using the MGISEQ-2000 platform. We identified a total of 138,936 unigenes, of which 32.35% were known genes. After infection with P. mirabilis, 801 genes showed differential expression, with 507 upregulated and 294 downregulated genes. These differentially expressed genes were enriched in pathways related to cytokine–cytokine receptor interaction, TNF signaling, and toll-like receptor signaling, according to Kyoto Encyclopedia of Genes and Genomes analysis. Following P. mirabilis infection, immune genes, including H2-Aa, hamp1, LYZ, CXCL10, and IRAK3, were significantly upregulated, while NLRP3, ADAM19, TYK2, FETUB, and MSR1 were significantly downregulated. The results provide important information on how the immune system of Chinese spiny frog responds to P. mirabilis infection and help understand the development of skin rot in cultured frog species.

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Characterization, Expression, and Functional Analysis of the Northern Snakehead (Channa argus) Hepcidin

Cited by 2 publications

References 61 publications

Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR/NFκB pathway

Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR/NFκB pathway

Transcriptomic analysis of liver immune response in Chinese spiny frog (Quasipaa spinosa) infected with Proteus mirabilis

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