2016
DOI: 10.1177/1934578x1601101201
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Characterization of 12-Oxophytodienoic Acid Reductases from Rose-scented Geranium (Pelargonium graveolens)

Abstract: Pelargonium graveolens L'Hér, also referred to as rose geranium, is a popular herbal plant with typical rosy fragrance largely based on the blend of monoterpenoid constituents. Among them, citronellol, which is biosynthesized from geraniol via double bond reduction, is the most abundant scent compound. In this study, three 12-oxophytodienoic acid reductases (PgOPR1-3) have been cloned from P. graveolens, as possible candidates for the double-bond reductase involved in citronellol biosynthesis. The bacterially … Show more

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Cited by 3 publications
(3 citation statements)
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“…Conversely, roses and pelargonium utilize a TPS-independent NUDX pathway for geraniol production [57][58][59]. It is widely acknowledged that citronellol originates from geraniol, catalyzed by a series of enzymes from diverse families [60][61][62][63][64]. However, the mechanisms underlying geraniol and citronellol biosynthesis in peonies remain elusive and require further characterization.…”
Section: P Lactiflora CV Zifengyu Is a Good Candidate For Extracting ...mentioning
confidence: 99%
“…Conversely, roses and pelargonium utilize a TPS-independent NUDX pathway for geraniol production [57][58][59]. It is widely acknowledged that citronellol originates from geraniol, catalyzed by a series of enzymes from diverse families [60][61][62][63][64]. However, the mechanisms underlying geraniol and citronellol biosynthesis in peonies remain elusive and require further characterization.…”
Section: P Lactiflora CV Zifengyu Is a Good Candidate For Extracting ...mentioning
confidence: 99%
“…Since ERs have demonstrated their chiral synthesis potential in the biotransformation of citronellal, researchers identified a series of ERs from different sources and tested their reduction 30,31 PgOPR1−3 from Pelargonium graveolens showed obvious preference for (Z)-citral reduction, similar to NCR, 27 and produced (S)-citronellal and (R)citronellal at a molar ratio of ∼95:5. 32 In addition, a multisubstrate reductase from Plantago major belonging to the SDR superfamily can also catalyze the reduction of citral, but the stereoselectivity of the product has not been detected. 33 YqjM from Bacillus subtilis, the most prominent member of OYE family members from thermophilic microorganisms, reduced (E/Z)-citral to yield (S)-citronellal in >95% ee.…”
Section: Terpenoid Flavormentioning
confidence: 99%
“…ERs in plants were first discovered from Lycopersion esculentum (tomato), known as 12-oxophydioate reductase (OPR). OPR1 and OPR3 from Lycopersion esculentum (tomato) reduced ( E )-citral to give ( S )-citronellal in greater than 95% ee . , PgOPR1–3 from Pelargonium graveolens showed obvious preference for ( Z )-citral reduction, similar to NCR, and produced ( S )-citronellal and ( R )-citronellal at a molar ratio of ∼95:5 . In addition, a multisubstrate reductase from Plantago major belonging to the SDR superfamily can also catalyze the reduction of citral, but the stereoselectivity of the product has not been detected .…”
Section: Terpenoid Flavormentioning
confidence: 99%