Characterization of a Central Corneal Cloudiness Sharing Features of Posterior Crocodile Shagreen and Central Cloudy Dystrophy of Fran??ois

Meyer, J; Quantock, Andrew J.; Thonar, Eugene J.‐M.A.; Kincaid, Marilyn C.; Hageman, Gregory S.; Assil, Kerry K.

doi:10.1097/00003226-199607000-00003

Cited by 15 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were no patent abnormalities on conventional OCT B-scans ( Figures 5D and 5E), but on consecutive OCT C-scans, we were able to visualize polygonal hyper-reflectivities with indistinct edges separated by clear lines ( Figure 5B in 3D mode and 5C in en-face mode), which could be the lacunae patterns previously described. 19 This pattern was present only in the posterior stroma, which is consistent with previously reported histological findings. 20 …”

Section: Crocodile Shagreen Dystrophysupporting

confidence: 92%

“…A saw-toothed lamellar pattern is often evident in the corneal stroma. 19 A 76-year-old woman presented with bilateral deep central stromal opacities in a polygonal pattern with intervening crack-like clear zones ( Figure 5A). There were no patent abnormalities on conventional OCT B-scans ( Figures 5D and 5E), but on consecutive OCT C-scans, we were able to visualize polygonal hyper-reflectivities with indistinct edges separated by clear lines ( Figure 5B in 3D mode and 5C in en-face mode), which could be the lacunae patterns previously described.…”

Section: Crocodile Shagreen Dystrophymentioning

confidence: 99%

See 1 more Smart Citation

En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and in Vivo Confocal Microscopy

et al. 2014

View full text Add to dashboard Cite

Section: Crocodile Shagreen Dystrophysupporting

confidence: 92%

Section: Crocodile Shagreen Dystrophymentioning

confidence: 99%

En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and in Vivo Confocal Microscopy

et al. 2014

View full text Add to dashboard Cite

“…Both articles were written before the advent of genotyping so no genetic information is available. Central cloudy dystrophy of François appears clinically indistinguishable from the degenerative condition, posterior crocodile shagreen 31. It is not possible to determine whether previous publications describing an individual patient with central cloudy dystrophy of François were actually describing patients with posterior crocodile shagreen 32.…”

Section: Does Every Single Dystrophy Actually Exist?mentioning

confidence: 99%

The IC3D Classification of the Corneal Dystrophies

Weiss

Møller

Lisch

et al. 2008

Cornea

247

View full text Add to dashboard Cite

Background The recent availability of genetic analyses has demonstrated the shortcomings of the current phenotypic method of corneal dystrophy classification. Abnormalities in different genes can cause a single phenotype, whereas different defects in a single gene can cause different phenotypes. Some disorders termed corneal dystrophies do not appear to have a genetic basis. Purpose The purpose of this study was to develop a new classification system for corneal dystrophies, integrating up-to-date information on phenotypic description, pathologic examination, and genetic analysis. Methods The International Committee for Classification of Corneal Dystrophies (IC3D) was created to devise a current and accurate nomenclature. Results This anatomic classification continues to organize dystrophies according to the level chiefly affected. Each dystrophy has a template summarizing genetic, clinical, and pathologic information. A category number from 1 through 4 is assigned, reflecting the level of evidence supporting the existence of a given dystrophy. The most defined dystrophies belong to category 1 (a well-defined corneal dystrophy in which a gene has been mapped and identified and specific mutations are known) and the least defined belong to category 4 (a suspected dystrophy where the clinical and genetic evidence is not yet convincing). The nomenclature may be updated over time as new information regarding the dystrophies becomes available. Conclusions The IC3D Classification of Corneal Dystrophies is a new classification system that incorporates many aspects of the traditional definitions of corneal dystrophies with new genetic, clinical, and pathologic information. Standardized templates provide key information that includes a level of evidence for there being a corneal dystrophy. The system is user-friendly and upgradeable and can be retrieved on the website www.corneasociety.org/ic3d.

show abstract

“…2 Other than the hereditary pattern, the central corneal opacities in both conditions are typically located in the axial two thirds of the cornea, are most dense posteriorly, and may extend into the anterior one third of the stroma. To date, the knowledge regarding the pathology of CCDF or posterior crocodile shagreen [3][4][5] has been limited. This may be owing to the difficulty in obtaining diseased corneas since the corneal opacities in CCDF or posterior corneal shagreen do not interfere with vision and the corneal opacities or corneal shagreen are usually asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Confocal Microscopy in Patients With Central Cloudy Dystrophyof François

Kobayashi¹

2004

Arch Ophthalmol

View full text Add to dashboard Cite

show abstract

Characterization of a Central Corneal Cloudiness Sharing Features of Posterior Crocodile Shagreen and Central Cloudy Dystrophy of Fran??ois

Cited by 15 publications

References 0 publications

En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and in Vivo Confocal Microscopy

En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and in Vivo Confocal Microscopy

The IC3D Classification of the Corneal Dystrophies

In Vivo Confocal Microscopy in Patients With Central Cloudy Dystrophyof François

Contact Info

Product

Resources

About