Characterization of a distinct low-grade oncocytic renal tumor (CD117-negative and cytokeratin 7-positive) based on a tertiary oncology center experience: the new evidence from China

Guo, Qian; Liu, Ning; Wang, Frank; Guo, Yuhong; Yang, Bo; Cao, Zi; Wang, Yalei; Wang, Yong; Zhang, Wenshuai; Huang, Qun; Zhao, Wei; Liu, Changxu; Qu, Tongyuan; Li, Lingmei; Cao, Lu Jia; Ren, Danyang; Meng, Bin; Qi, Lisha; Wang, Cheng; Cao, Weijun

doi:10.1007/s00428-020-02927-0

Cited by 33 publications

(33 citation statements)

References 25 publications

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“…Recent studies have shown that LOT may rarely be multiple and/or bilateral [ 17 , 25 , 29 ]. LOT is typically a tan/brown, solid tumor, which may show edematous or hemorrhagic focal areas on a cut surface [ 24 , 27 , 28 , 30 , 31 ].…”

Section: Low-grade Oncocytic Tumor (Lot)mentioning

confidence: 99%

TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background

et al. 2022

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A number of recently described renal tumor entities share an eosinophilic/oncocytic morphology, somewhat solid architectural growth pattern, and tendency to present as low-stage tumors. The vast majority of such tumors follow a non-aggressive clinical behavior. In this review, we discuss the morphological, immunohistochemical, and molecular genetic profiles of the three most recent novel/emerging renal entities associated with TSC/mTOR pathway mutations. These are eosinophilic solid and cystic renal cell carcinoma, eosinophilic vacuolated tumors, and low-grade oncocytic tumors, which belong to a heterogeneous group of renal tumors, demonstrating mostly solid architecture, eosinophilic/oncocytic cytoplasm, and overlapping morphological and immunohistochemical features between renal oncocytoma and chromophobe renal cell carcinoma. All three tumors also share a molecular genetic background with mutations in the mTORC1 pathway (TSC1/TSC2/mTOR/RHEB). Despite the common genetic background, it appears that the tumors with TSC/mTOR mutations represent a diverse group of distinct renal neoplasms.

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Section: Low-grade Oncocytic Tumor (Lot)mentioning

confidence: 99%

TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background

et al. 2022

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“…On the other hand, many tumors among those reported by Trpkov et al exhibited 19p33.3 and 1p36.33 deletions [4]. Guo et al reported eight tumors that exhibited features consistent with the tumor entities described by Trpkov et al [5]. The cases reported by Guo et al were morphologically similar to the cases reported by Trpkov et al, and many of them had features consistent with LOT [5].…”

Section: Discussionmentioning

confidence: 60%

“…The classification of renal tumors with oncocytic/eosinophilic cytoplasm has been rapidly organized in recent years. Particularly, tumors that have emerged as new entities in recent years include SDH-deficient RCC [ 7 ], thyroid-like follicular RCC [ 8 ], ALK-rearrangement RCC [ 9 ], high-grade oncocytic renal tumor [ 10 ], oChRCC [ 3 ], LOT [ 4 , 5 ], and eosinophilic solid and cystic RCC [ 11 ]. Oncocytoma, eCRCC, clear cell RCC, and 2-pRCC are well-defined entities that are also listed as differential diagnoses [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, new disease entities have been discovered in recent years. Differentiation diagnosis is important for oncocytic/eosinophilic renal tumors [ 6 ] including succinate dehydrogenase- (SDH-) deficient renal cell carcinoma [ 7 ], thyroid-like follicular RCC [ 8 ], ALK-rearrangement RCC [ 9 ], high-grade oncocytic renal tumor [ 10 ], LOT [ 4 , 5 ], oChRCC [ 3 ], and eosinophilic solid and cystic renal cell carcinomas [ 11 ]. Among these, oChRCC and LOT are tumors that are similar to oncocytoma but are characterized by diffuse and dense immunoreactivity for CK7 [ 2 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, cases are often experienced wherein these tumors cannot be differenti-ated even with various immunostaining techniques. Diffuse and dense CK7 positivity has been observed even in tumors that were morphologically similar to oncocytoma [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney

Ishikawa¹,

Kimura²,

Yoshida

et al. 2021

Case Reports in Pathology

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The oncocytic variant of chromophobe renal cell carcinoma (oChRCC) and low-grade oncocytic tumor (LOT) is introduced as new renal disease entity. Both of these tumors are low-grade malignancies consisting of cells with eosinophilic cytoplasm. Distinguishing between eosinophilic variant of chromophobe renal cell carcinoma (eCRCC) and oncocytoma is often a diagnostic challenge in routine surgical pathology. However, oChRCC and LOT might be independent disease entities that might not fit completely into any of these categories. Histologically, these tumors have greater morphological similarity with oncocytoma than with ChRCC. However, immunohistochemically, they exhibit diffuse and dense positivity for CK7 and are negative for CD117. In the present case, we initially had difficulty distinguishing among oncocytoma, eCRCC, and type 2 papillary renal cell carcinoma (2-pRCC). However, after learning about new disease entities such as oChRCC and LOT, we were able to diagnose this tumor.

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Low-grade oncocytic tumor of the kidney: imaging features of a novel tumor entity

Bodard,

Delavaud,

Dariane

et al. 2024

Abdom Radiol

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Characterization of a distinct low-grade oncocytic renal tumor (CD117-negative and cytokeratin 7-positive) based on a tertiary oncology center experience: the new evidence from China

Cited by 33 publications

References 25 publications

TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background

TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background

A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney

Low-grade oncocytic tumor of the kidney: imaging features of a novel tumor entity

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