Characterization of a nanocomposite scaffold and assessment of its osteogenic influence in a rabbit mandibular bone defect model

Hany, Eman; El-Wassefy, Noha A.; Yahia, Sarah; Elkhier, Mazen Abou; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ajoms.2022.07.001

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…The study highlights the significant role of natural polymer research in developing effective materials for bone tissue regeneration, potentially having significant clinical applications. Hany et al [ 73 ] studied bone tissue regeneration using a nanofibrous composite scaffold containing polycaprolactone (PCL), alginate (Alg), and hydroxyapatite (HA). The composite showed biocompatibility and suitable properties, with experimental rabbits with mandibular defects showing enhanced bone healing with well-organized and mature bone formation.…”

Section: Exploring Diverse Scaffold Varieties: Unveiling Properties A...mentioning

confidence: 99%

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Saberian,

Jenča,

Zafari

et al. 2024

Cells

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Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells and targeted 3D scaffolds have been investigated in the search for workable solutions. The use of scaffolds in stem cell-assisted bone regeneration is a crucial component of tissue engineering techniques designed to overcome the drawbacks of traditional bone grafts. This study provides a detailed review of scaffold applications for bone regeneration with stem cells in dentistry. This review focuses on scaffolds and stem cells while covering a broad range of studies explaining bone regeneration in dentistry through the presentation of studies conducted in this field. The role of different stem cells in regenerative medicine is covered in great detail in the reviewed literature. These studies have addressed a wide range of subjects, including the effects of platelet concentrates during dental surgery or specific combinations, such as human dental pulp stem cells with scaffolds for animal model bone regeneration, to promote bone regeneration in animal models. Noting developments, research works consider methods to improve vascularization and explore the use of 3D-printed scaffolds, secretome applications, mesenchymal stem cells, and biomaterials for oral bone tissue regeneration. This thorough assessment outlines possible developments within these crucial regenerative dentistry cycles and provides insights and suggestions for additional study. Furthermore, alternative creative methods for regenerating bone tissue include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser therapy, nutritional supplements and diet, gene therapy, and biomimetic materials. These innovative approaches offer promising avenues for future research and development in the field of bone tissue regeneration in dentistry.

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Section: Exploring Diverse Scaffold Varieties: Unveiling Properties A...mentioning

confidence: 99%

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Saberian,

Jenča,

Zafari

et al. 2024

Cells

View full text Add to dashboard Cite

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Enhancing osteogenesis and mandibular defect repair with magnesium-modified acellular bovine bone matrix

Wang,

Ge,

et al. 2024

J Mater Sci: Mater Med

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An acellular bovine bone matrix modified to release Magnesium ions (Mg 2+ ) (ABBM-Mg) was prepared and evaluated for its potential in osteogenesis and mandibular defect repair. Mg 2+ was incorporated into ABBM using an ion exchange method. The microstructure and mechanical properties of both ABBM and ABBM-Mg were analyzed using SEM and a biomechanical testing machine. Cytocompatibility, cell adhesion, and osteogenic differentiation were assessed using various methods including CCK-8, Live/Dead staining, SEM, ALP staining, and qPCR analysis in MC3T3-E1 cells. Additionally, a mandibular defect model in rats was established. The bone defect repair outcomes were evaluated using Micro-CT, histological HE staining, and Masson staining. The study showed that mineralization containing magnesium was redeposited on the surface of the three-dimensional porous ABBM, and the ABBM-Mg scaffold promoted cell proliferation and osteogenic differentiation compared to the ABBM scaffold. In the rat mandibular defect model, the ABBM-Mg scaffold demonstrated superior bone repair ability. This study successfully incorporated Mg 2+ into ABBM without significantly affecting its microstructure and compressive strength. Furthermore, ABBM-Mg showed sustained release of Mg 2+ which enhanced cell proliferation, adhesion, and osteogenic differentiation in vitro, and promoted mandibular defect healing in rats. This research opens up new possibilities for the clinical application of functionalized acellular bone matrix. Graphical Abstract

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Photobiostimulation Enhances the Osteogenic Differentiation of Gingival-Derived Stem Cells Seeded on Nanocomposite Scaffolds

Hany,

Emam,

Elbeltagy

et al. 2024

Regen. Eng. Transl. Med.

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Characterization of a nanocomposite scaffold and assessment of its osteogenic influence in a rabbit mandibular bone defect model

Cited by 4 publications

References 36 publications

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Enhancing osteogenesis and mandibular defect repair with magnesium-modified acellular bovine bone matrix

Photobiostimulation Enhances the Osteogenic Differentiation of Gingival-Derived Stem Cells Seeded on Nanocomposite Scaffolds

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