1983
DOI: 10.1007/bf02618053
|View full text |Cite
|
Sign up to set email alerts
|

Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture

Abstract: A new human endometrial cell line, RL95-2, derived from a Grade 2 moderately differentiated adenosquamous carcinoma of the endometrium has been passaged successfully in cell culture for more than 2 yr. The cells are characteristically epithelioid with well-defined junctional complexes, tonofilaments, filopodialike extensions, and surface microvilli. Nuclei are large, irregular, and invaginated frequently with multiple, prominent, lamellar nucleoli. The cells have a log phase doubling time of 22 to 34 h followe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
75
0

Year Published

1993
1993
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 169 publications
(76 citation statements)
references
References 39 publications
1
75
0
Order By: Relevance
“…S4D-S4H). Both of these cells were derived from type I endometrial tumors from postmenopausal Caucasian women, with the RL cells derived from an obese woman but the BMI is unknown for the source of the 296 cells (23,24). SMARTpool (Pool) siRNA reduced GLUT6 protein expression in 296 cells by 65%, whereas siRNA sequence 4 (Seq.4; a single sequence from the SMARTpool) reduced GLUT6 protein expression by 90%, compared with controls ( Fig.…”
Section: Glut6 Promotes Glycolysis and Survival Of Endometrial Cancermentioning
confidence: 99%
“…S4D-S4H). Both of these cells were derived from type I endometrial tumors from postmenopausal Caucasian women, with the RL cells derived from an obese woman but the BMI is unknown for the source of the 296 cells (23,24). SMARTpool (Pool) siRNA reduced GLUT6 protein expression in 296 cells by 65%, whereas siRNA sequence 4 (Seq.4; a single sequence from the SMARTpool) reduced GLUT6 protein expression by 90%, compared with controls ( Fig.…”
Section: Glut6 Promotes Glycolysis and Survival Of Endometrial Cancermentioning
confidence: 99%
“…The RL95 cell line is isolated from a moderately differentiated adenosquamous carcinoma of the endometrium. 33 HEC1A cells were isolated from a stage IA endometrial cancer. 34 Both cell lines are invasive in vitro 35 and in vivo.…”
Section: Tumor Microenvironment Growth Factors Induce Expression Of Mmentioning
confidence: 99%
“…The endometrial epithelial carcinoma cell lines HEC1A, HEC1B, Ishikawa and RL952 have previously been extensively characterised (Kuramoto 1972, Way et al 1983, Gollub et al 1993. All cell lines express ER but HEC1B cells have been shown to be devoid of immunoreactive PR (Gao et al 1994).…”
Section: Endometrial Epithelial Cell Linesmentioning
confidence: 99%