Characterization of a novel bioactive composite using advanced X-ray computed tomography

Gupta, Gautam; Zbib, A.A.; El‐Ghannam, Ahmed; Khraisheh, Marwan; Zbib, Hussein M.

doi:10.1016/j.compstruct.2005.09.023

Cited by 19 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…State of the art three-dimensional imaging techniques enable researchers to describe the complex structure of materials more accurately. Microcomputed tomography (mCT), a non-destructive technique, is being increasingly used to provide structural information within an object by mathematically reconstructing its three-dimensional images from a consecutive series of x-ray images [37][38][39]. This technique provides the opportunity to experimentally measure the complex morphology of the pore space of scaffolds in three dimensions at resolutions in the micrometre range.…”

Section: Introductionmentioning

confidence: 99%

Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique

2008

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique

2008

View full text Add to dashboard Cite

“…The ability of SCPC75 to provide a slow release rate of rhBMP2 without prior burst release is a major advantage that eliminates the risk of severe side effects associated with high doses of rhBMP2. Unlike polymeric implants, the SCPC is distinguished by inherent bioactivity property that enables the material, even without growth factors, to stimulate bone cell differentiation and tissue formation . Therefore, the ability of SCPC75‐Vanc‐rhBMP2 device to provide a sustained dual release of antibiotic and growth factor for up to 28 days makes it superior to other polymeric carriers reported in the literature .…”

Section: Discussionmentioning

confidence: 99%

Tissue engineering scaffold for sequential release of vancomycin and rhBMP2 to treat bone infections

Pacheco

Vedantham

Aniket

et al. 2014

J. Biomed. Mater. Res.

Self Cite

View full text Add to dashboard Cite

The ability of silica calcium phosphate nanocomposite (SCPC75) for the controlled sequential delivery of vancomycin (Vanc) and rhBMP2 was evaluated. Fourier transform infrared spectroscopy analyses of the SCPC75 showed an increase in the bond energy of the PO4 (-3) due to the interactions with negatively charged moieties of Vanc. Furthermore, a decrease in the bond energy of the Si-O-Si functional groups was observed after rhBMP2 adsorption. In conjunction with the differences in bond site and bond energy at the ceramic/drug interface, significant differences in drug release kinetics and bioceramic dissolution rate were found. UV-vis spectrometry showed a burst release of Vanc in the first 8 h followed by a sustained release stage for up to 28 days. ELISA showed first-order release kinetics of rhBMP2 without burst release. The rhBMP2 release from SCPC75 was associated with a significantly lower rate of Ca and a higher rate of Si dissolutions when compared with Vanc release over identical time periods. Differences in the release kinetic profiles of Vanc and rhBMP2 from the SCPC75-Vanc/SCPC75-rhBMP2 scaffolds at 70/30, 50/50, or 20/80 ratios allowed for sequential drug release profiles that could be exploited to customize doses and release duration of each drug. The released rhBMP2 significantly upregulated MC3T3-E1 expression of collagen type I, osteopontin, and osteocalcin mRNA by 12.6-, 3.3-, and 2.4-fold, respectively. The released Vanc demonstrated bactericidal effects on Staphylococcus aureus in vitro. These results suggest the potential of SCPC75-Vanc-rhBMP2 scaffolds in the treatment of damaged and/or infected bone.

show abstract

“…It is important to note, that the current technology does not render this method for field application since core specimens have to be extracted from the original structure. Gupta et al [17] used X-ray CT for studying the microstructure of porous silica-calcium phosphate nanocomposite in load bearing biomedical applications. X-ray synchrotron tomography, which uses radiation within the electromagnetic spectrum, has shown promising results in identifying iron-rich areas of metal matrix composites and the detection of porosity as well as damage growth [18,19] .…”

Section: Introductionmentioning

confidence: 99%

Porosity Content Evaluation in Carbon-Fiber/Epoxy Composites Using X-ray Computed Tomography

Yang

Elhajjar

2014

Polymer-Plastics Technology and Engineering

View full text Add to dashboard Cite

In this study we investigate the X-ray computed tomography method for assessment of porosity levels in carbon-fiber/epoxy composites. High resolution computed tomography is used to investigate the distribution, size, and morphology of porosity in composite specimens. The specimens are manufactured with porosity values in ranges that are encountered in the manufacturing of composite structures. Porosity measurement from the optical scans is found to be highly dependent on the number of cross-sections investigated. The stacking sequence is found to have a high effect on the measurements made especially at higher porosity levels due to the preferential alignment of the porosity microstructure. INTRODUCTIONPorosity or distributed voids are a common manufacturing anomaly that can have detrimental effects on the performance and mechanical properties of composite materials. This is intimately tied to the improvement and customization of manufacturing procedures [1,2] . Thus, accurate quantification of the voids is an area of great importance for characterization of composite materials. Porosity can be caused and influenced by several factors including the entrapment of air or moisture between plies, cure pressure fluctuations, and the stacking sequence between the plies [3,4] . Several attempts have been made to study this behavior and predict the locations of its occurrence [5][6][7] .Toscano and Vitiello [8] showed how the stacking sequence can yield to a higher propensity of the porosity to occur. Porosity levels were found to be greater when plies are stacked perpendicular to another or in a [45 =À45 ] sequence and are lowest when stacked as unidirectional. The effects on the mechanical properties have also been examined. Costa et al. [9] studied the effect of porosity on moisture absorption and showed how a significant amount of absorption may occur depending on the void content and

show abstract

Characterization of a novel bioactive composite using advanced X-ray computed tomography

Cited by 19 publications

References 10 publications

Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique

Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique

Tissue engineering scaffold for sequential release of vancomycin and rhBMP2 to treat bone infections

Porosity Content Evaluation in Carbon-Fiber/Epoxy Composites Using X-ray Computed Tomography

Contact Info

Product

Resources

About