Characterization of a novel enamel sealer for bioactive remineralization of white spot lesions

Abbassy, Mona Aly; Bakry, Ahmed; Almoabady, Ebraheem H.; Almusally, Sumana M.; Hassan, Ali

doi:10.1016/j.jdent.2021.103663

Cited by 30 publications

(15 citation statements)

References 31 publications

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“…Also, newer methods such as Fluorescence Induced Theragnosis can be used to compare findings between various fluoride-releasing agents [ 44 ]. In terms of remineralizing the enamel, one effective method that has been demonstrated previously is the use of 45S5 bioglass which was shown to form brushite crystals on treated enamel surfaces [ 45 , 46 ]. As can be seen from the limitations, there is a definite potential to explore the role of various fluoride-releasing agents against white spot lesions and demineralization.…”

Section: Discussionmentioning

confidence: 99%

An Extensive Comparison of the Clinical Efficiency of Acidulated Phosphate Fluoride (APF) and Neutral Sodium Fluoride (NaF) Oral Rinses in the Prevention of White Spot Lesions during Fixed Orthodontic Treatment: A Randomized Controlled Trial

Pilli

Singaraju

Nettam

et al. 2022

BioMed Research International

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Background. The purpose of this randomized trial is to compare the efficacy of weekly once regime of neutral sodium fluoride (NaF) oral rinse with that of acidulated phosphate (APF) formulated daily mouth rinse in the reduction of white spot lesions (WSLs) associated with fixed orthodontic appliance treatment. Methods. The participants ( n = 90 ) of this single-center, two-arm parallel study without a control group were randomly assigned with 1 : 1 distribution to each of the two groups after the bonding of brackets. Group A/test group 1 ( n = 45 ) was given weekly rinse of neutral sodium fluoride (Colgate® PreviDent® Dental Rinse-0.2% NaF), and for group B/test group 2 ( n = 45 ), an APF formulated daily oral rinse (Colgate® Ortho Defense@ PhosFlur® Rinse-0.044% w/v of NaF) was given for six months. The outcome was assessed by the International Caries Detection and Assessment System (ICDAS) index for scoring the demineralization, and for scoring gingivitis, Loe and Silness gingival index (GI) was utilized. Four different time points “T0”immediately before bonding procedures, “T1” after 4weeks, “T2” after 12 weeks, and “T3” after 24 weeks were taken to assess the ICDAS and GI scores. Results. The mean ICDAS scores for group A (NaF) were 0.025, 0.051, 0.093, and 0.113 and for group B (APF) were 0.014, 0.022, 0.038, and 0.015 at different points of time. The GI scores for group A were 0.008, 0.22, 0.33, and 0.38 and for group B were 0.003, 0.136, 0.181, and 0.097 at different time points. There was a statistically significant difference ( p < 0.05 ) for both groups in terms of reducing WSL and GI. Conclusion. APF formulated daily oral rinse—0.044% w/v of NaF—is more effective than the weekly once regimen of 0.2% NaF oral rinse to prevent white spot lesions.

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Section: Discussionmentioning

confidence: 99%

An Extensive Comparison of the Clinical Efficiency of Acidulated Phosphate Fluoride (APF) and Neutral Sodium Fluoride (NaF) Oral Rinses in the Prevention of White Spot Lesions during Fixed Orthodontic Treatment: A Randomized Controlled Trial

Pilli

Singaraju

Nettam

et al. 2022

BioMed Research International

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“…In this context, calcium phosphate nanoparticles have been shown to be osteoconductive [25]. Especially brushite, CaHPO 4 × 2 H 2 O, can act as a connecting layer binding to enamel, mediating remineralization and undergoing transformation to hydroxyapatite [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Root Canal Obturation by Electrochemical Precipitation of Calcium Phosphates

et al. 2022

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Achieving adequate disinfection and preventing reinfection is the major goal in endodontic treatment. Variation in canal morphology and open porosity of dentine prevents achieving complete disinfection. Questionable biocompatibility of materials as well as a lack of sealing ability questions the usefulness of current obturation methods. With a novel disinfection approach based on the use of boron-doped diamond (BDD) electrodes having shown promising results it was the goal of this series of experiments to investigate the possibility of BDD-mediated in situ forming of a biocompatible obturation material. A combination of calcium phosphate and maleic acid was used as precursor solution while Ion Chromatography Mass Spectrometry (IC-MS), Raman spectroscopy (RAMAN), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), dye penetration and micro-computed tomography (µCT) were applied for characterizing the precipitate. It was possible to achieve a BDD-mediated precipitation of brushite in a clinically applicable timeframe. However, tight sealing of the canal system based on brushite could not be achieved.

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“…The camouflage technique employs resin infiltration, whereas the second method, which is the most debated and is currently being researched, refers to mineral structure recapturing. The remineralization approach offers a variety of options, ranging from the commonly used fluoride and casein phosphopeptide-amorphous calcium phosphate products in various forms to the newly added substances in adhesion, pastes, or solutions, such as bioactive glass, nanohydroxyapatite, peptide p11-4, and cold plasma [10][11][12][13][14][15]. The evolution of research in dental prophylaxis is ongoing to identify the best product for caries prevention and the remineralization of the white spot lesion.…”

Section: Introductionmentioning

confidence: 99%

“…The bioactive glass material interacts with cells and tissues and starts a layer inside the saliva. The general similarity in the chemical constituents of enamel and bone material has increased interest in dentistry [11,[20][21][22]. Another material recently gaining popularity is the peptide p11-4, a class of peptides that goes through a hierarchical order and a predetermined process of scaffold assembly and formation.…”

Section: Introductionmentioning

confidence: 99%

Novel Technology for Enamel Remineralization in Artificially Induced White Spot Lesions: In Vitro Study

et al. 2022

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The enamel white spot lesion is a common complication of orthodontic treatment with a high prevalence. This research aims to create an artificially induced white spot lesion, evaluate three different commercial products in terms of visual appeal, mineral reestablishment, and roughness, and determine which material can recover the initial structure. We created an artificially induced white spot lesion in extracted teeth. The materials used in the study were peptide p11-4 (CurodontTM Repair, Credentis AG), bioactive glass toothpaste (Biomin F, BioMin Technologies Limited), and local fluoridation (Tiefenfluorid, Humanchemie) in conjunction with low-level laser therapy (LLLT). To objectively assess the surface, the roughness, mineral content, and esthetic were measured. The roughness increased with a median difference of −0.233 µm in the bioactive glass group; the color parameter delta L decreased dramatically with a median difference of 5.9–6.7; and the cervical third increased the Ca-P mineral content above the starting stage. Each material contributed significantly to enamel consolidation, with peptide therapy providing the most encouraging results.

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Characterization of a novel enamel sealer for bioactive remineralization of white spot lesions

Cited by 30 publications

References 31 publications

An Extensive Comparison of the Clinical Efficiency of Acidulated Phosphate Fluoride (APF) and Neutral Sodium Fluoride (NaF) Oral Rinses in the Prevention of White Spot Lesions during Fixed Orthodontic Treatment: A Randomized Controlled Trial

An Extensive Comparison of the Clinical Efficiency of Acidulated Phosphate Fluoride (APF) and Neutral Sodium Fluoride (NaF) Oral Rinses in the Prevention of White Spot Lesions during Fixed Orthodontic Treatment: A Randomized Controlled Trial

Root Canal Obturation by Electrochemical Precipitation of Calcium Phosphates

Novel Technology for Enamel Remineralization in Artificially Induced White Spot Lesions: In Vitro Study

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