Characterization of a Time-Resolved, Real-Time Scintillation Dosimetry System for Ultra-High Dose-Rate Radiation Therapy Applications

Baikalov, Alexander; Tho, Daline; Liu, Kevin; Bartzsch, Stefan; Beddar, Sam; Schüler, Emil

doi:10.1016/j.ijrobp.2024.11.092

International Journal of Radiation Oncology*Biology*Physics

2024

DOI: 10.1016/j.ijrobp.2024.11.092

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Characterization of a Time-Resolved, Real-Time Scintillation Dosimetry System for Ultra-High Dose-Rate Radiation Therapy Applications

Alexander Baikalov,

Daline Tho,

Kevin Liu

et al.

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2024

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Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments

Wang,

Melemenidis,

Manjappa

et al. 2024

Medical Physics

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BackgroundFLASH radiation therapy (RT) offers a promising avenue for the broadening of the therapeutic index. However, to leverage the full potential of FLASH in the clinical setting, an improved understanding of the biological principles involved is critical. This requires the availability of specialized equipment optimized for the delivery of conventional (CONV) and ultra‐high dose rate (UHDR) irradiation for preclinical studies. One method to conduct such preclinical radiobiological research involves adapting a clinical linear accelerator configured to deliver both CONV and UHDR irradiation.PurposeWe characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra‐high dose rate irradiation to two anatomic sites in mice and for cell‐culture FLASH radiobiology experiments.MethodsDelivered doses of UHDR electron beams were controlled by a microcontroller and relay interfaced with the respiratory gating system. We also produced beam collimators with indexed stereotactic mouse positioning devices to provide anatomically specific preclinical treatments. Treatment delivery was monitored directly with an ionization chamber, and charge measurements were correlated with radiochromic film measurements at the entry surface of the mice. The setup for conventional dose rate irradiation utilized the same collimation system but at increased source‐to‐surface distance. Monte Carlo simulations and film dosimetry were used to characterize beam properties and dose distributions.ResultsThe mean electron beam energies before the flattening filter were 18.8 MeV (UHDR) and 17.7 MeV (CONV), with corresponding values at the mouse surface of 17.2 and 16.2 MeV. The charges measured with an external ion chamber were linearly correlated with the mouse entrance dose. The use of relay gating for pulse control initially led to a delivery failure rate of 20% (± 1 pulse); adjustments to account for the linac latency improved this rate to < 1/20. Beam field sizes for two anatomically specific mouse collimators (4 × 4 cm2 for whole‐abdomen and 1.5 × 1.5 cm2 for unilateral lung irradiation) were accurate within < 5% and had low radiation leakage (< 4%). Normalizing the dose at the center of the mouse (∼0.75 cm depth) produced UHDR and CONV doses to the irradiated volumes with > 95% agreement.ConclusionWe successfully configured a clinical linear accelerator for increased output and developed a robust preclinical platform for anatomically specific irradiation, with highly accurate and precise temporal and spatial dose delivery, for both CONV and UHDR irradiation applications.

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Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments

Wang,

Melemenidis,

Manjappa

et al. 2024

Medical Physics

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Characterization of an Inorganic Powder-Based Scintillation Detector Under a UHDR Electron Beam

Tho,

Beddar

2024

Sensors

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(1) Background: Ultra-high dose rate (UHDR) radiation therapy needs a reliable dosimetry solution and scintillation detectors are promising candidates. In this study, we characterized an inorganic powder-based scintillation detector under a 9 MeV UHDR electron beam. (2) Methods: A mixture of ZnS:Ag powder and optic glue was coupled to an 8 m Eska GH-4001-P polymethyl methacrylate (PMMA) optical fiber. We evaluated the dependence of the detector on dose per pulse (DPP), pulse repetition frequency (PRF), and pulse width (PW). Additionally, we determined the stability and the reproducibility of the detector. (3) Results: The signal ratio between the PMMA clear optical fiber and the ZnS:Ag scintillator was around 210. ZnS:Ag produced a signal yield 54 times greater than that of a BCF-12 plastic scintillator. Signal variation with PRF changes was under 0.5%. The signal was linear to the integrated dose up to the maximum deliverable dose, 180 Gy. The variation in signal was linear to the change in both PW and DPP. Regarding stability, the standard deviation of 10 consecutive irradiations was 0.83%. For the reproducibility, all daily measurements varied within ±1.5%. (4) Conclusions: These findings show that the ZnS:Ag detector can be used for accurate dosimetry with UHDR beams.

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Characterization of a Time-Resolved, Real-Time Scintillation Dosimetry System for Ultra-High Dose-Rate Radiation Therapy Applications

Cited by 2 publications

References 40 publications

Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments

Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments

Characterization of an Inorganic Powder-Based Scintillation Detector Under a UHDR Electron Beam

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