Characterization of ACE inhibitory and antioxidant peptides in yak and cow milk hard chhurpi cheese of the Sikkim Himalayan region

Abedin, Md Minhajul; Chourasia, Rounak; Phukon, Loreni Chiring; Singh, Sudhir P.; Kumar, Amit

doi:10.1016/j.fochx.2022.100231

Cited by 39 publications

(24 citation statements)

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“…Food-derived peptides have demonstrated interaction with β-CoV structural proteins and NSPs that may prevent viral infection and proliferation [ 28 , 104 ]. Bioactive peptides released upon fermentation of foods exert several functionalities that include antimicrobial, antioxidant, antihypertensive, and anticancer properties and can be explored to develop nutraceuticals and therapeutics ( Figure 3 ) [ 109–112 ]. Fermented food-derived peptides have previously demonstrated high antiviral activity against viral pathogens [ 113 ].…”

Section: Peptide-based Chemotherapeutics Against β-Covsmentioning

confidence: 99%

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

et al. 2022

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Betacoronaviruses (β-CoVs) have caused major viral outbreaks in the last two decades in the world. The mutation and recombination abilities in β-CoVs resulted in zoonotic diseases in humans. Proteins responsible for viral attachment and replication are highly conserved in β-CoVs. These conserved proteins have been extensively studied as targets for preventing infection and the spread of β-CoVs. Peptides are among the most promising candidates for developing vaccines and therapeutics against viral pathogens. The immunostimulatory and viral inhibitory potential of natural and synthetic peptides has been extensively studied since the SARS-CoV outbreak. Food-derived peptides demonstrating high antiviral activity can be used to develop effective therapeutics against β-CoVs. Specificity, tolerability, and customizability of peptides can be explored to develop potent drugs against β-CoVs. However, the proteolytic susceptibility and low bioavailability of peptides pose challenges for the development of therapeutics. This review illustrates the potential role of peptides in eliciting an adaptive immune response and inhibiting different stages of the β-CoV life cycle. Further, the challenges and future directions associated with developing peptide-based therapeutics and vaccines against existing and future β-CoV pathogens have been discussed.

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Section: Peptide-based Chemotherapeutics Against β-Covsmentioning

confidence: 99%

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

et al. 2022

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“…Hypertension seriously affects the morbidity and mortality of cardiovascular and renal diseases (Kharazmi-Khorassani et al, 2019;Abedin et al, 2022). Because of the different lifestyles and genetic factors, the number of people with high blood pressure is now about 1.3×10 6 , but this number is expected to rise to 1.56 ×10 6 by 2030 (Mabhida et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the chemosynthetic ACE inhibitors (captopril (Cap), lisinopril, enalapril, etc.) have been widely used in treating heart failure and hypertension in the clinical (Fan et al, 2019;Chakraborty and Roy, 2022), but the disturbing thing is those synthetic ACE inhibitors display some serious adverse symptoms, such as headache, impaired taste perception, dizziness, chronic dry cough, nausea, and hyperkalemia (Lee et al, 2010;Lee and Hur, 2017;Abedin et al, 2022). Therefore, researchers are focusing on searching safer ACE inhibitors from natural resources as the alternatives of synthetic ACE inhibitors to control hypertension (Abedin et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Isolation, identification, molecular docking analysis, and cytoprotection of seven novel angiotensin I-converting enzyme inhibitory peptides from miiuy croaker byproducts-swim bladders

et al. 2022

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For efficiently utilizing the processing byproducts of miiuy croaker to prepare novel angiotensin I-converting enzyme (ACE) inhibitory (ACEi) peptides, in vitro gastrointestinal (GI) digestion method was screened and employed to prepare swim bladder hydrolysate with the highest ACEi activity. Subsequently, seven novel ACEi peptides were isolated from the hydrolysate and identified as DEGPE, EVGIQ, SHGEY, GPWGPA, GPFGTD, SPYGF, and VIGPF with molecular weights of 545.49, 544.58, 591.55, 583.63, 592.59, 569.60, and 531.63 Da, respectively. SHGEY and SPYGF exhibited remarkable ACEi activity with IC50 values of 0.86 ± 0.12 and 0.37 ± 0.06 mg/mL. Molecular docking experiment illustrated that the significant ACEi activity of SHGEY and SPYGF with the affinity of -8.7 and -9.7 kcal/mol mainly attributed to effectively combining with the ACEi active sites by hydrophobic interaction, electrostatic force and hydrogen bonding. Moreover, SHGEY and SPYGF could significantly up-regulate the nitric oxide (NO) production and decrease the endothelin-1 (ET-1) secretion in human umbilical vein endothelial cells (HUVECs), but also abolished the negative impacting of norepinephrine to the levels of NO and ET-1. Furthermore, SHGEY and SPYGF showed significant protection to HUVECs against H2O2 damage by increasing superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity to lower the contents of reactive oxide species and malondialdehyde. Consequently, ACEi peptides derived from miiuy croaker swim bladders, especially SHGEY and SPYGF, are health-promoting ingredients for functional products as a supplementary treatment to hypertension and cardiovascular diseases.

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“…Abedin et al identified numerous antioxidant peptides in the gastrointestinal tract of Tibetan yak following simulated digestion. 8 By employing multi-strain mixed fermented milk, Taha et al found that the degree of hydrolysis could reach 70%, and the free radical scavenging ability increased continuously within 15 d of refrigeration. This result is because the fermentation of mixed fermentation strains can complement the growth of single strains, improve the mutual coordination ability between strains, and increase the hydrolysis effect of strains.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H₂O₂-injured HT-22 cells

Jiang

Liu

et al. 2022

Food Funct.

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Characterization of ACE inhibitory and antioxidant peptides in yak and cow milk hard chhurpi cheese of the Sikkim Himalayan region

Cited by 39 publications

References 40 publications

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

Isolation, identification, molecular docking analysis, and cytoprotection of seven novel angiotensin I-converting enzyme inhibitory peptides from miiuy croaker byproducts-swim bladders

Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H₂O₂-injured HT-22 cells

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Characterization of ACE inhibitory and antioxidant peptides in yak and cow milk hard chhurpi cheese of the Sikkim Himalayan region

Cited by 39 publications

References 40 publications

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

Isolation, identification, molecular docking analysis, and cytoprotection of seven novel angiotensin I-converting enzyme inhibitory peptides from miiuy croaker byproducts-swim bladders

Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H2O2-injured HT-22 cells

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Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H₂O₂-injured HT-22 cells