Characterization of Actinomyces species isolated from failed dental implant fixtures

Sarkonen, Nanna; Könönen, Eija; Eerola, Erkki; Könönen, Mauno; Jousimies‐Somer, Hannele; Laine, Pekka

doi:10.1016/j.anaerobe.2005.01.002

Cited by 25 publications

(14 citation statements)

References 35 publications

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“…Sarkonen et al isolated A. graevenitzii from failed dental implant surfaces for their study on the distribution of Actinomyces spp. in 33 dental implant fixtures (12). Similar to other Actinomyces spp., A. graevenitzii is possibly a component of the oropharyngeal flora.…”

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confidence: 58%

Multiple Lung Abscesses Caused by Actinomyces graevenitzii Mimicking Acute Pulmonary Coccidioidomycosis

Nagaoka

Izumikawa²,

Yamamoto³

et al. 2012

J Clin Microbiol

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c Actinomyces graevenitzii is a newly recognized Actinomyces species that is seldom isolated from clinical specimens. A case of multiple pulmonary abscesses mimicking acute pulmonary coccidioidomycosis is described in this study, and the findings indicate that this organism is an opportunistic human pathogen. CASE REPORTA 38-year-old apparently healthy woman complained of fever and dry cough after visiting Los Angeles, CA. Her medical history did not reveal any specific illness, including acquired immune deficiency syndrome. She did not smoke or consume alcohol. During her 3-day stay, she visited the beach in California. On her way to the beach, she encountered a dust storm and inhaled a large amount of dust. Seven days after she returned to Japan (9 days after encountering the dust storm), she was admitted to a local hospital in Nagasaki owing to a progressive dry cough (clinical day 8). On admission, the vital signs of the patient were as follows: body temperature, 37.5°C; blood pressure, 99/64 mm Hg; pulse, 72 beats/min with a regular rhythm; SpO 2 , 96% in a room air condition; and respiratory rate, 16 breaths/min. Cyanosis, cardiac murmur, and breath sounds were absent. Moreover, her liver, spleen and lymph nodes were not palpable. Her white blood cell count was 7.3 ϫ 10 3 /ml, with a shift to the left (71% neutrophils), and her C-reactive protein value was 5 mg/dl (normal range, 0 to 0.3 mg/dl). The chest computed tomography (CT) images revealed multiple round lesions located on both lobes, with diameters of 0.5 to 1 cm ( Fig. 1 and 2). The radiological findings strongly suggested metastatic tumors; hence, digestive tract endoscopy and positron emission tomography (PET) of the entire body were performed. No other lesions, except the lesions in the lungs, were found to contribute to the findings. Two weeks later (clinical day 21), the multiple pulmonary lesions had grown in size by 3-fold, with partial cavity formation ( Fig. 1 and 2). Owing to the extreme rapid progression of the lesions, the patient was transferred to our hospital for further examination and treatment. An oral antibiotic, faropenem (FRPM), at 600 mg/day was given from clinical days 21 to 24. On admission (clinical day 25), we suspected acute pulmonary coccidioidomycosis because of her travel history to the U.S. West Coast and the similarities of her CT images with those of typical pulmonary Coccidioides infection (3), and we administered liposomal amphotericin B (L-AMB) at 150 mg/day intravenously on clinical day 26. We also initiated tazobactam-piperacillin (TAZ-PIPC) therapy at 18 g/day concurrently, because the presence of other bacterial infections was not completely excluded. Before the initiation of antibiotic therapy, a transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath was performed 48 h after the cessation of FRPM treatment. The presence of antibodies against Coccidioides was also examined before the initiation of antifungal treatment (clinical day 26). After 9 days of treatment (clinical day 35),...

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confidence: 58%

Multiple Lung Abscesses Caused by Actinomyces graevenitzii Mimicking Acute Pulmonary Coccidioidomycosis

Nagaoka

Izumikawa²,

Yamamoto³

et al. 2012

J Clin Microbiol

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“…The known cross-reactivity of the checkerboard method may explain this unusual finding. Furthermore, A. odontolyticus, A. israelii, A. naeslundii/"A. viscosus," A. meyeri, and A. gerencseriae, in descending order, have been recovered from a case of pericoronitis of wisdom teeth (194), while A. odontolyticus, A. naeslundii, "A. viscosus," A. israelii, A. georgiae, A. gerencseriae, and A. graevenitzii, in descending order, were recovered from 33 failed dental implant fixtures, which had been removed due to infection (195). When bone was harvested from jawbone(s) for augmentation procedures, which may occasionally be needed for successful implantation of dental implant fixtures, A. odontolyticus was found to be among the most frequent contaminants of bone debris (196).…”

Section: Oral Infectionsmentioning

confidence: 99%

Actinomyces and Related Organisms in Human Infections

2015

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SUMMARY Actinomyces israelii has long been recognized as a causative agent of actinomycosis. During the past 3 decades, a large number of novel Actinomyces species have been described. Their detection and identification in clinical microbiology laboratories and recognition as pathogens in clinical settings can be challenging. With the introduction of advanced molecular methods, knowledge about their clinical relevance is gradually increasing, and the spectrum of diseases associated with Actinomyces and Actinomyces -like organisms is widening accordingly; for example, Actinomyces meyeri , Actinomyces neuii , and Actinomyces turicensis as well as Actinotignum (formerly Actinobaculum ) schaalii are emerging as important causes of specific infections at various body sites. In the present review, we have gathered this information to provide a comprehensive and microbiologically consistent overview of the significance of Actinomyces and some closely related taxa in human infections.

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“…This is not surprising since A. graevenitzii, like other species of Actinomyces, is a colonizer of the oropharynx (7,8). However, A. graevenitzii is recovered less frequently than A. odontolyticus, A. naeslundii, and A. israelii (7). We are unaware of data regarding the prevalence of A. graevenitzii as a colonizer of the oropharynx in adult populations such as the one served by our hospital.…”

Section: Amentioning

confidence: 62%

“…graevenitzii is most commonly recovered from oral or respiratory specimens and is often present in low numbers (6,13,14). This is not surprising since A. graevenitzii, like other species of Actinomyces, is a colonizer of the oropharynx (7,8). However, A. graevenitzii is recovered less frequently than A. odontolyticus, A. naeslundii, and A. israelii (7).…”

Section: Amentioning

confidence: 94%

Pseudo-Outbreak of Actinomyces graevenitzii Associated with Bronchoscopy

et al. 2015

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Outbreaks and pseudo-outbreaks of infection related to bronchoscopy typically involve Gram-negative bacteria, Mycobacterium species or Legionella species. We report an unusual bronchoscopy-related pseudo-outbreak due to Actinomyces graevenitzii. Extensive epidemiological and microbiological investigation failed to identify a common source. Strain typing revealed that the cluster was comprised of heterogeneous strains of A. graevenitzii. A change in laboratory procedures for Actinomyces cultures was coincident with the emergence of the pseudo-outbreak, and we determined that A. graevenitzii isolates more readily adopted a white, dry, molar tooth appearance on anaerobic colistin nalidixic acid (CNA) agar which likely facilitated its detection and identification in bronchoscopic specimens. This unusual pseudo-outbreak was related to frequent requests of bronchoscopists for Actinomyces cultures combined with a change in microbiology laboratory practices. Actinomyces graevenitzii is infrequently identified in clinical specimens, and its pathogenicity is not well defined. A. graevenitzii is a component of the oropharyngeal microbiota and has been reported to cause pneumonia, lung abscesses, osteitis of the jaw, and bacteremia (1-8). In early December 2013, an increase in the recovery of A. graevenitzii from specimens from patients who underwent bronchoscopy was noted by microbiology and infection control staff. Our investigation revealed that the cluster of A. graevenitzii isolates represented a pseudo-outbreak associated with a change in laboratory practices. MATERIALS AND METHODS Setting.A 1,500-bed tertiary care university-affiliated teaching hospital was the setting for this study.Epidemiological investigation. The microbiology laboratory's computerized database was queried to obtain the number of bronchoscopy cultures performed, the number of Actinomyces cultures ordered on bronchoscopy specimens, and the number of those cultures ordered that were positive for Actinomyces from January 2011 through December 2013. Medical records of patients whose bronchoscopy specimens yielded Actinomyces were reviewed, and the following variables were recorded: date of bronchoscopy, results of bronchoscopic specimen cultures for routine respiratory pathogens and for Actinomyces, bronchoscope used, bronchoscopist, endoscopy personnel involved in the procedure, procedure room number, and medications administered during bronchoscopy procedures. Only three bronchoscopes were routinely used, and almost all bronchoscopies were performed in procedure room 3. Therefore, we focused our investigation on room 3, the three bronchoscopes, and the "wash room" in which all bronchoscopes and endoscopes undergo highlevel disinfection using one of three automated endoscope reprocessors (AERs) (DSDs Medivators, Minneapolis, MN). Findings of cytologic examination and bronchial biopsy specimens were also recorded.Environmental sources of samples collected for culture in the endoscopy suite included unopened bottles of lidocaine, atomizer, cotton ball...

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Characterization of Actinomyces species isolated from failed dental implant fixtures

Cited by 25 publications

References 35 publications

Multiple Lung Abscesses Caused by Actinomyces graevenitzii Mimicking Acute Pulmonary Coccidioidomycosis

Multiple Lung Abscesses Caused by Actinomyces graevenitzii Mimicking Acute Pulmonary Coccidioidomycosis

Actinomyces and Related Organisms in Human Infections

Pseudo-Outbreak of Actinomyces graevenitzii Associated with Bronchoscopy

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