2022
DOI: 10.3390/mi13030480
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Characterization of Active Electrode Yield for Intracortical Arrays: Awake versus Anesthesia

Abstract: Intracortical microelectrode arrays are used for recording neural signals at single-unit resolution and are promising tools for studying brain function and developing neuroprosthetics. Research is being done to increase the chronic performance and reliability of these probes, which tend to decrease or fail within several months of implantation. Although recording paradigms vary, studies focused on assessing the reliability and performance of these devices often perform recordings under anesthesia. However, ane… Show more

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Cited by 8 publications
(9 citation statements)
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“…For implantation of the first device cohort (functional devices), the surgical procedure was performed following established protocols. , Briefly, adult male rats (275–530 g) were anesthetized using vaporized isoflurane (1.8–2.2%) mixed with medical grade oxygen (500 mL/min; SomnoSuite for Mice & Rats, Kent Scientific Corporation, Torrington, CT, US). Following removal of scalp fur, animals were transferred onto a stereotaxic frame (David Kopf Instruments, Tujunga, CA, US).…”
Section: Methodsmentioning
confidence: 99%
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“…For implantation of the first device cohort (functional devices), the surgical procedure was performed following established protocols. , Briefly, adult male rats (275–530 g) were anesthetized using vaporized isoflurane (1.8–2.2%) mixed with medical grade oxygen (500 mL/min; SomnoSuite for Mice & Rats, Kent Scientific Corporation, Torrington, CT, US). Following removal of scalp fur, animals were transferred onto a stereotaxic frame (David Kopf Instruments, Tujunga, CA, US).…”
Section: Methodsmentioning
confidence: 99%
“…The incision was then closed using surgical staples and the animals were given 5 mg/kg intramuscular cefazolin (Med-Vet International, Mettawa, IL, US) as infection prophylaxis, and depending on availability either 1.2 mg/kg of subcutaneous slow-release buprenorphine (ZooPharm, LLC., Laramie, WY, US) or 1.3 mg/kg subcutaneous extended-release buprenorphine (Ethiqa XR, Fidelis Animal Health, North Brunswick, NJ, USA) for pain management every 72 h for 5 days. Animals were provided sulfamethoxazole and trimethoprim oral suspension (200 mg and 40 mg per 5 mL, Aurobindo Pharma, Dayton, NJ, US) in their drinking water (1 mL suspension/100 mL drinking water) for 1 week postimplantation. ,, For the second cohort, animals were prepared for surgery and device implantation, as detailed above. Craniotomies of approximately 1 mm × 1 mm were made ±3 mm lateral from midline and 2 mm anterior/posterior from bregma.…”
Section: Methodsmentioning
confidence: 99%
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“…Rats underwent a surgical procedure for sham and MEA implantation as previously described ( Sturgill et al, 2022 ). Briefly, animals were anesthetized using vaporized isoflurane (1.8–2.5%) mixture with medical grade oxygen (500 ml/min, SomnoSuite® for Mice & Rats, Kent Scientific Corporation, Torrington, CT, US).…”
Section: Methodsmentioning
confidence: 99%
“…6A with end points of 4-weeks and 12-weeks post-implantation. All surgical procedures followed established protocols in our combined labs 110,111 . Brie y, mice were anesthetized in an iso urane chamber (3.5% at 0.8 L/min O 2 ).…”
Section: Intracortical Microelectrode Implantationmentioning
confidence: 99%