“…81,92,93 Those individuals who go on to develop persistent pain show signs of altered central pain processing, like diffuse mechanical hyperalgesia, thermal hyperalgesia, and/or lower thresholds to painful electrical stimulation, as early as 1 month after injury. 21,31,92,93 Patients with chronic pain exhibit primary mechanical hyperalgesia over the back of the cervical spine, in a "coat hanger" distribution indicative of peripheral nociceptor sensitization. 21,81 These patients are also hypersensitive to pressure, heat, and cold stimuli at sites distant from the cervical spine, including over the median, radial, and ulnar nerve trunks in the arm and over the tibialis anterior muscle.…”