Characterization of Aerosols Produced during Surgical Procedures in Hospitals

Yeh, Hsu‐Chi; Turner, R. S.; Jones, Robert; Muggenburg, B.A.; Lundgren, D.L.; Smith, Jerome P.

doi:10.1080/02786829408959736

Cited by 57 publications

(53 citation statements)

References 26 publications

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“…Such applications have included measurement of water pollution [24], detection of microscopic entities such as virus nanoparticles [25], quantification of smoke types including outdoor tobacco smoke [26] and to assess occupational exposure to blood and bone cautery smoke derived from orthopaedic surgery [27]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances

Adamson

Thorne

Dalrymple

et al. 2013

Chemistry Central Journal

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BackgroundCigarette smoking is a cause of a variety of serious diseases, and to understand the toxicological impact of tobacco smoke in vitro, whole smoke exposure systems can be used. One of the main challenges of the different whole smoke exposure systems that are commercially available is that they dilute and deliver smoke in different ways, limiting/restricting the cross-comparison of biological responses. This is where dosimetry – dose quantification – can play a key role in data comparison. Quartz crystal microbalance (QCM) technology has been put forward as one such tool to quantify smoke particle deposition in vitro, in real-time.ResultsUsing four identical QCMs, installed into the Vitrocell® mammalian 6/4 CF Stainless exposure module, we were able to quantify deposited smoke particle deposition, generated and diluted by a Vitrocell® VC 10 Smoking Robot. At diluting airflows 0.5-4.0 L/min and vacuum flow rate 5 ml/min/well through the exposure module, mean particle deposition was in the range 8.65 ± 1.51 μg/cm2-0.72 ± 0.13 μg/cm2. Additionally, the effect of varying vacuum flow rate on particle deposition was assessed from 5 ml/min/well - 100 ml/min/well. Mean deposited mass for all four airflows tested per vacuum decreased as vacuum rate was increased: mean deposition was 3.79, 2.75, 1.56 and 1.09 μg/cm2 at vacuum rates of 5, 10, 50 and 100 ml/min/well respectively.ConclusionsQCMs within the Vitrocell® exposure module have demonstrated applicability at defining particle dose ranges at various experimental conditions. This tool will prove useful for users of the Vitrocell® system for dose–response determination and QC purposes.

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Section: Introductionmentioning

confidence: 99%

Assessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances

Adamson

Thorne

Dalrymple

et al. 2013

Chemistry Central Journal

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“…The QCM technology itself is not new and in the past it has been used for such activities as environmental monitoring [21, 25], biological applications [26, 27], and inhalation toxicity assessment of (nontobacco) aerosols and engineered nanoparticles in vitro [19, 28, 29]. However, the utilisation and combination of these technologies for assessment of whole smoke exposure in vitro is novel.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Cigarette Smoke Particle DepositionIn VitroUsing a Triplicate Quartz Crystal Microbalance Exposure Chamber

Adamson

Thorne

McAughey

et al. 2013

BioMed Research International

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There are a variety of smoke exposure systems available to the tobacco industry and respiratory toxicology research groups, each with their own way of diluting/delivering smoke to cell cultures. Thus a simple technique to measure dose in vitro needs to be utilised. Dosimetry—assessment of dose—is a key element in linking the biological effects of smoke generated by various exposure systems. Microbalance technology is presented as a dosimetry tool and a way of measuring whole smoke dose. Described here is a new tool to quantify diluted smoke particulate deposition in vitro. The triplicate quartz crystal microbalance (QCM) chamber measured real-time deposition of smoke at a range of dilutions 1 : 5–1 : 400 (smoke : air). Mass was read in triplicate by 3 identical QCMs installed into one in vitro exposure chamber, each in the location in which a cell culture would be exposed to smoke at the air-liquid interface. This resulted in quantification of deposited particulate matter in the range 0.21–28.00 μg/cm2. Results demonstrated that the QCM could discriminate mass between dilutions and was able to give information of regional deposition where cell cultures would usually be exposed within the chamber. Our aim is to use the QCM to support the preclinical (in vitro) evaluation of tobacco products.

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“…As per the existing study [1], aerosol production is usually the highest during the initial part of the surgery during surgical site incision using electrocautery, especially when accompanied by suction and irrigation. More blood during the procedure also contributes to more aerosol production.…”

Section: Operative Casesmentioning

confidence: 90%

Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic

et al. 2020

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During this unprecedented time of the coronavirus disease 2019 (COVID 19) pandemic, most countries are struggling to optimize their healthcare resources. Although the prevention and treatment of COVID 19 has become the priority for the majority of the population, most medical professionals are facing the challenge of balancing the management of this pandemic and treating patients with other diseases. Healthcare professionals from all specialties are facing this situation and designing guidelines and recommendations that are contributing to the literature that is crucial for disease management at the current time. We share our experience with two ends of the spectra that we currently observe in spine patients. One group of patients included the non-operative cases that presented with back pain. Further, we discuss our experience with operative precautions and digitally assisted discharge.

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Characterization of Aerosols Produced during Surgical Procedures in Hospitals

Cited by 57 publications

References 26 publications

Assessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances

Assessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances

Quantification of Cigarette Smoke Particle DepositionIn VitroUsing a Triplicate Quartz Crystal Microbalance Exposure Chamber

Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic

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