2012
DOI: 10.1016/j.ijpharm.2012.03.041
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Characterization of agglomerated carvedilol by hot-melt processes in a fluid bed and high shear granulator

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Cited by 27 publications
(23 citation statements)
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“…It can be concluded that there was no evidence of polymorph transformation during the melt granulation process. However, somewhat lower intensities of diffraction lines in the physical mixture and granulates were observed and were attributed to lower drug content due to dilution of carvedilol in the physical mixture and granules, as already observed in a previous study (19).…”
Section: Solid State Characterizationsupporting
confidence: 82%
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“…It can be concluded that there was no evidence of polymorph transformation during the melt granulation process. However, somewhat lower intensities of diffraction lines in the physical mixture and granulates were observed and were attributed to lower drug content due to dilution of carvedilol in the physical mixture and granules, as already observed in a previous study (19).…”
Section: Solid State Characterizationsupporting
confidence: 82%
“…4) and used for analytics of dissolution samples. y = 28.214x -0.0058 (R 2 = 0.9998) [4] Carvedilol solubility in phosphate buffer pH 6.8 for pure drug (20 mg mL -1 ) and granules with P188 to drug ratio 1:3 (89 mg mL -1 ) was reported (19). Data indicate that moderate excess solubilizing capacity of the dissolution medium was achieved for pure drug.…”
Section: X-ray Powder Diffraction (Xrpd)mentioning
confidence: 97%
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“…For carvedilol, less precipitation is expected in the duodenum and fed-state intestinal fluid as apparent from the dissolution results of carvedilol in acetate buffer pH 4.5 and blank FeSSIF. Nonetheless, SIFsp and 0.05 M phosphate buffer (IntPh3) remain commonly used as compendial dissolution media (7,11,(38)(39)(40)(41)(42).…”
Section: Dissolution Studiesmentioning
confidence: 99%
“…It has a log P value of 3.8 with a basic pK a of 7.8 (6) and an acidic pK a of 15.0 (calculated using ChemAxon software). Carvedilol exhibits pH-dependent solubility (7). It dissolves in the acidic pH of the stomach, as it is presented in its ionized form.…”
Section: Introductionmentioning
confidence: 99%