Characterization of airborne PAHs and metals associated with PM10 fractions collected from an urban area of Sri Lanka and the impact on airway epithelial cells.

Abayalath, Nirodha; Malshani, Indeepa; Ariyaratne, Rajitha; Zhao, Shizhen; Zhong, Guangcai; Zhang, Gan; Manipura, A.; Siribaddana, Anoma; Karunaratne, P.; Kodithuwakku, Suranga P.

doi:10.1016/j.chemosphere.2021.131741

Cited by 16 publications

(10 citation statements)

References 90 publications

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“… 296 In another recently published study, cellular DNA damage and aberrant gene expression patterns associated with PM10 were shown in the airways cells. 297 Furthermore, PM10 strongly stimulated messenger RNA expression and secretion of the pro‐inflammatory cytokines IL‐6 and CXCL1 in mouse airway epithelial cells and it induced the expression of IL‐6, IL‐8, and IL1B in human airway epithelial cells. 298 It must be noted that a link has been reported with PM 10 exposure not only to asthma but also to other inflammatory diseases.…”

Section: Environmental Substances Affecting the Epithelial Barriersmentioning

confidence: 95%

“…PM10 was reported to induce alveolar epithelial dysfunction by reducing occludin at the plasma membrane and dissociation of ZO‐1 in human and primary rat alveolar epithelial cells 296 . In another recently published study, cellular DNA damage and aberrant gene expression patterns associated with PM10 were shown in the airways cells 297 . Furthermore, PM10 strongly stimulated messenger RNA expression and secretion of the pro‐inflammatory cytokines IL‐6 and CXCL1 in mouse airway epithelial cells and it induced the expression of IL‐6, IL‐8, and IL1B in human airway epithelial cells 298 .…”

Section: Environmental Substances Affecting the Epithelial Barriersmentioning

confidence: 97%

“…Environmental substances affecting the epithelial barriers[282,[284][285][286][288][289][290][291][292][293][294][295][296][297][298]300] Degrade TJ proteins, downregulate occludin and claudin−1 expression, suppress E-cadherin levels (especially PM 2.5 &PM10)…”

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confidence: 99%

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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

222

166

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Environmental exposure plays a major role in the development of allergic diseases.The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which are interrelated. All the factors we are exposed to, from the moment of conception to death, are part of the external exposome. Several hundreds of thousands of new chemicals have been introduced in modern life without our having a full understanding of their toxic health effects and ways to mitigate these effects.Climate change, air pollution, microplastics, tobacco smoke, changes and loss of biodiversity, alterations in dietary habits, and the microbiome due to modernization, urbanization, and globalization constitute our surrounding environment and external exposome. Some of these factors disrupt the epithelial barriers of the skin and mucosal surfaces, and these disruptions have been linked in the last few decades to the increasing prevalence and severity of allergic and inflammatory diseases such as atopic dermatitis, food allergy, allergic rhinitis, chronic rhinosinusitis, eosinophilic

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Section: Environmental Substances Affecting the Epithelial Barriersmentioning

confidence: 95%

Section: Environmental Substances Affecting the Epithelial Barriersmentioning

confidence: 97%

See 1 more Smart Citation

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

222

166

View full text Add to dashboard Cite

show abstract

“…It is clear that interaction among the metalloids may affect their bioavailability and speciation in cells thus regulating their combined effects [47] . Unlike CYP1A1 induction in some other cell types, PM10 predominated by high molecular weight PAH induces up-regulation of CYP1B1 in procrine airway epithelial cell [40] . Some reports showed that CYP1A2 and CYP1B1 induction is less likely in human blood vessel endothelial [48] , [49] , [50] , [51] .…”

Section: Search String and Databasesmentioning

confidence: 82%

Genetic and epigenetic modulations in toxicity: The two-sided roles of heavy metals and polycyclic aromatic hydrocarbons from the environment

Adegbola,

Adetutu

2024

Toxicology Reports

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“…73 Inhaling volatile organic pollutants, such as polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs), can harm lung health by compromising barrier integrity, increasing mucus production, altering airway epithelium fluids, and inducing cytotoxicity, DNA damage, and the upregulation of genes associated with inflammation and carcinogenesis. 74,75 In summary, the respiratory system's exposure to various EPs highlights the intricate interplay between external factors and respiratory health outcomes. Two specific cell lines are commonly used for their unique characteristics and advantages in respiratory toxicity research: A549 and BEAS-2B.…”

Section: Respiratory Toxicity Modelsmentioning

confidence: 99%

Advancing Environmental Toxicology In Vitro: From Immortalized Cancer Cell Lines to 3D Models Derived from Stem Cells

Li,

Yin,

Yang

et al. 2024

Environ. Health

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In recent years, rapid industrial development has resulted in the production and exposure of a substantial number of compounds to the human body. This has created an urgent need in environmental toxicology for models that are efficient, accurate, and cost-effective in evaluating the health impacts of these compounds on humans. Over the past seven decades, various cancer cell lines and immortalized cell lines have made significant contributions to the advancement of research on organ toxicity. Pluripotent stem cell technology, especially toxicological models derived from pluripotent stem cells, presents modern environmental toxicologists with high-throughput, species-relevant, and predictive options. In this comprehensive review, we assess the characteristics of representative human cancer cell lines and immortalized cell lines in environmental toxicology, as well as introduce two distinct human pluripotent stem cell types and their innovative toxicological models. We explore their applications and prospects in the field of environmental toxicology, while also addressing the readiness of in vitro models to confront the emerging challenges of the future.

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Characterization of airborne PAHs and metals associated with PM10 fractions collected from an urban area of Sri Lanka and the impact on airway epithelial cells.

Cited by 16 publications

References 90 publications

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Genetic and epigenetic modulations in toxicity: The two-sided roles of heavy metals and polycyclic aromatic hydrocarbons from the environment

Advancing Environmental Toxicology In Vitro: From Immortalized Cancer Cell Lines to 3D Models Derived from Stem Cells

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