Characterization of ambient aerosols at the San Francisco International Airport using bioaerosol mass spectrometry

Steele, Paul T.; McJimpsey, Erica L.; Coffee, Keith R.; Fergenson, David P.; Riot, Vincent; Tobias, Herbert J.; Woods, Bruce W.; Gard, Eric E.; Frank, Matthias

doi:10.1117/12.665155

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…While the earliest reports of single particle bioaerosol mass spectra come from laboratory standards Gieray et al 1997), SPMS has been increasingly applied to the detection of bioaerosols via aircraft or at high alpine research stations, i.e., to measure the chemical composition of ice residuals and aerosols both in and outside of clouds (Creamean et al 2013;Pratt et al 2009a;Schmidt et al 2017). SPMS has also been applied for the detection of agents of biological warfare and for public health monitoring (Czerwieniec et al 2005;Frank et al 2011;Russell et al 2004;Steele et al 2006;Tobias et al 2005). The system deployed by Steele et al (2006), in particular, paired SPMS with LIF detection of PBAP.…”

Section: Bioaerosol Detection By Online Massmentioning

confidence: 99%

Real-time sensing of bioaerosols: Review and current perspectives

Huffman

Perring

Savage

et al. 2019

Aerosol Science and Technology

190

138

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Detection of bioaerosols, or primary biological aerosol particles (PBAPs), has become increasingly important for a wide variety of research communities and scientific questions. In particular, real-time (RT) techniques for autonomous, online detection and characterization of PBAP properties in both outdoor and indoor environments are becoming more commonplace and have opened avenues of research. With advances in technology, however, come challenges to standardize practices so that results are both reliable and comparable across technologies and users. Here, we present a critical review of major RT instrument classes that have been applied to PBAP research, especially with respect to environmental science, allergy monitoring, agriculture, public health, and national security. Eight major classes of RT techniques are covered, including the following: (i) fluorescence spectroscopy, (ii) elastic scattering, microscopy, and holography, (iii) Raman spectroscopy, (iv) mass spectrometry, (v) breakdown spectroscopy, (vi) remote sensing, (vii) microfluidic techniques, and (viii) paired aqueous techniques. For each class of technology we present technical limitations, misconceptions, and pitfalls, and also summarize best practices for operation, analysis, and reporting. The final section of the article presents pressing scientific questions and grand challenges for RT sensing of PBAP as well as recommendations for future work to encourage high-quality results and increased cross-community collaboration.

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Section: Bioaerosol Detection By Online Massmentioning

confidence: 99%

Real-time sensing of bioaerosols: Review and current perspectives

Huffman

Perring

Savage

et al. 2019

Aerosol Science and Technology

190

138

View full text Add to dashboard Cite

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“…T he Bioaerosol Mass Spectrometry (BAMS) system was developed for national security and public health applications including the real-time, in situ detection of airborne pathogens [1] and biowarfare agents [2,3]. It has the ability to distinguish Bacillus spores from vegetative cells on a particle by particle basis using ion peaks under m/z 300 [4], and has demonstrated preliminary species level differentiation of individual Bacillus spores using low mass biomarker peaks [5,6].…”

mentioning

confidence: 99%

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

McJimpsey

Jackson

Lebrilla

et al. 2008

J. Am. Soc. Mass Spectrom.

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The Bioaerosol Mass Spectrometry (BAMS) system was developed for the real-time detection and identification of biological aerosols using laser desorption ionization. Greater differentiation of particle types is desired; consequently MALDI techniques are being investigated. The small sample size (ϳ1 m 3 ), lack of substrate, and ability to simultaneously monitor both positive and negative ions provide a unique opportunity to gain new insight into the MALDI process. Several parameters known to influence MALDI molecular ion yield and formation are investigated here in the single particle phase. A comparative study of five matrices (2,6-dihydroxyacetophenone, 2,5-dihydroxybenzoic acid, ␣-cyano-4-hydroxycinnamic acid, ferulic ␣ acid, and sinapinic acid) with a single analyte (angiotensin I) is presented and reveals effects of matrix selection, matrix-to-analyte molar ratio, and aerosol particle diameter. The strongest analyte ion signal is found at a matrix-to-analyte molar ratio of 100:1. At this ratio, the matrices yielding the least and greatest analyte molecular ion formation are ferulic acid and ␣-cyano-␣ 4-hydroxycinnamic acid, respectively. Additionally, a significant positive correlation is found between aerodynamic particle diameter and analyte molecular ion yield for all matrices. SEM imaging of select aerosol particle types reveals interesting surface morphology and structure.

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“…During this test, an early version of the SPAMS system containing a single fluorescence stage (with 266 nm excitation) operated in an air handler for one of the airport terminals for nearly 7 weeks in a semi-autonomous fashion (56,57). It should be noted that the fluorescence stage was not operated in pre-screening mode in this field test.…”

Section: Field Applications Of Spamsmentioning

confidence: 97%