2020
DOI: 10.1016/j.jcis.2020.01.088
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Characterization of an amino acid based biodegradable surfactant facilitating the incorporation of DNA into lipophilic delivery systems

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Cited by 13 publications
(11 citation statements)
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“…9 Promising results for HIP with such surfactants were obtained, for instance, by forming ion pairs of pDNA with a lysine based surfactant namely hexadecyl lysinate (HL) and complexes of daptomycin as well as heparin could be prepared with argininesurfactants. 10,11 These studies, however, showed also that an even more lipophilic character of HIPs would be advantageous. A pronounced lipophilicity of HIPs is crucial to exploit their full potential when administering them via lipid-based nanocarrier systems, as it determines the payload and the amount of complex remaining within the carrier after administration.…”
Section: Introductionmentioning
confidence: 99%
“…9 Promising results for HIP with such surfactants were obtained, for instance, by forming ion pairs of pDNA with a lysine based surfactant namely hexadecyl lysinate (HL) and complexes of daptomycin as well as heparin could be prepared with argininesurfactants. 10,11 These studies, however, showed also that an even more lipophilic character of HIPs would be advantageous. A pronounced lipophilicity of HIPs is crucial to exploit their full potential when administering them via lipid-based nanocarrier systems, as it determines the payload and the amount of complex remaining within the carrier after administration.…”
Section: Introductionmentioning
confidence: 99%
“… 27 , 28 Furthermore, lipase was already shown to hydrolyze nonionic surfactants containing carbonate, ester, and amide bonds, 29 as well as to cleave ester bonds in lipophilic lysin esters. 30 Both Arg-esters were degraded in vitro by lipase into free amino acid and alcohol as illustrated in Figure 4 . Cleavage of Arg-esters was confirmed by a constant drop in pH over time.…”
Section: Resultsmentioning
confidence: 99%
“…A similar lysine-based cationic compound hexadecyl lysinate (HL) was noncytotoxic to Caco-2 cells at the higher tested concentration of 250 μg mL –1 . 30 …”
Section: Resultsmentioning
confidence: 99%
“…Amino acid-based amphiphiles are promising in obtaining drugs based on surfactant–protein complexes [ 19 ] and can be used in oil recovery [ 20 ], as nonviral vectors in gene therapy [ 21 ], in cosmetics [ 22 ], etc. The main requirements for the resulting amphiphiles are multifunctionality, low toxicity and biodegradability [ 23 ].…”
Section: Self-assembly Of Amphiphilic Compoundsmentioning
confidence: 99%