2003
DOI: 10.1161/01.hyp.0000046924.94886.ef
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Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

Abstract: Abstract-Blood pressure (BP) increases in postmenopausal women. The mechanisms responsible are unknown. The present study was performed to characterize a model of postmenopausal hypertension in the rat and to determine the role that oxidative stress may play in mediating the postmenopausal hypertension. Spontaneously hypertensive rats were ovariectomized (ovx) or left intact (PMR) at 8 months and were aged to 18 months. These animals were compared with young females (YF; 4 or 8 months of age) and old males (18… Show more

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Cited by 132 publications
(151 citation statements)
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“…Thus the 12M E 2 -replaced animals never experienced a decline in reproductive function in contrast to the Intact animals, which experienced a sevenfold decrease in estradiol levels by 12 mo of age even though they had not reached the age of cycle cessation as observed in other rat strains (44). The aim of our study was to examine the effects of OVX and E 2 replacement in aged DSS rats that were in the state of E 2 deficiency rather than menopause (cessation of cycling).…”
Section: Discussionmentioning
confidence: 69%
“…Thus the 12M E 2 -replaced animals never experienced a decline in reproductive function in contrast to the Intact animals, which experienced a sevenfold decrease in estradiol levels by 12 mo of age even though they had not reached the age of cycle cessation as observed in other rat strains (44). The aim of our study was to examine the effects of OVX and E 2 replacement in aged DSS rats that were in the state of E 2 deficiency rather than menopause (cessation of cycling).…”
Section: Discussionmentioning
confidence: 69%
“…2014) since they have very little renal injury at this age as noted by urinary protein excretion (Fortepiani et al. 2003). Rats were also implanted with radiotelemetry transmitters (TA11PA‐C40; Data Sciences International, St. Paul, MN) into the abdominal aorta below the renal arteries, as we previously described (Yanes et al.…”
Section: Methodsmentioning
confidence: 99%
“…2003), and have evaluated the mechanisms responsible for their elevated blood pressure. The female SHR have lower blood pressure than males prior to 10–12 months of age when they stop estrous cycling (Fortepiani et al.…”
Section: Introductionmentioning
confidence: 99%
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