Characterization of an ssDNA ligase and its application in aptamer circularization

Ma, Zhenxia; Chen, Han; Yang, Yao; Gao, Siyi; Yang, Jiaping; Cui, Shihai; Zhou, Shiyuan; Jiang, Boyang; Zou, Bin; Sun, Mingjuan; Wang, Lianghua

doi:10.1016/j.ab.2023.115409

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Therapeutic Classes Of Ons1

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2024

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“…The most frequently utilized enzymatic ligation strategy involves the application of T4 ligase and CircLigase. 133 , 134 However, enzymatic reactions have a relatively low circularization yield due to their low selectivity for intramolecular circularization over intermolecular ligation. 135 An alternative approach to circularizing ssDNA molecules through ligase-mediated ligation involves utilizing Twister ribozymes to flank the RNA of interest leading to cleavage followed by subsequent ligation of both ends by endogenous RNA ligase RtcB.…”

Section: Therapeutic Classes Of Onsmentioning

confidence: 99%