Characterization of an Unusual Strain of Proteus rettgeri Associated with an Outbreak of Nosocomial Urinary-Tract Infection

Traub, W. H.; Craddock, M. E.; Raymond, E. A.; Fox, M.; McCall, C. E.

doi:10.1128/aem.22.3.278-283.1971

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…Two studies have provided evidence of nosocomial outbreaks of urinary tract infections caused by Prov. rettgeri (Traub et al 1971;Richard et al 1974). In both studies the infecting strains had the rare ability to ferment lactose.…”

Section: Discussionmentioning

confidence: 99%

Numerical analysis of electrophoretic protein patterns of Providencia rettgeri strains from human faeces, urine and other specimens

Costas¹,

Holmes²,

Wood³

et al. 1989

Journal of Applied Bacteriology

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Thirty-one strains of Providencia rettgeri (mainly from humans) were characterized by one-dimensional SDS-PAGE of cellular proteins. The strains came from various countries and comprised 14 from urine, eight from faeces, two from bile (plus one from the liver of a sheep), two from sputum, one from an insect pupa and three the sources of which were unknown. Also included, for reference purposes, were the type strains of the four other Providencia species. The protein patterns, which contained 45-50 discrete bands, were highly reproducible and were used as the basis for two numerical analyses. In the first, which included all the protein bands, the 31 Prov. rettgeri strains formed 13 clusters at the 84% S level. In the second analysis, in which the principal protein bands (in the 33.3-41.3 kD range) were excluded, 29 of the 31 Prov. rettgeri strains formed a single cluster at the 81% S level, whilst the four Providencia reference strains remained unclustered. We conclude that high resolution PAGE combined with computerized analysis of protein patterns provides the basis for typing clinical strains of Prov. rettgeri. Reference strains of each of the 13 PAGE types identified are available from NCTC for inclusion in future studies.

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Section: Discussionmentioning

confidence: 99%

Numerical analysis of electrophoretic protein patterns of Providencia rettgeri strains from human faeces, urine and other specimens

Costas¹,

Holmes²,

Wood³

et al. 1989

Journal of Applied Bacteriology

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“…There have been rare incidents of P. rettgeri causing nosocomial infections. Traub et al reported an outbreak of urinary tract infections caused by a highly resistant lactose-fermenting strain of P. rettgeri (102). While the organism was easily traceable because of this unusual biochemical characteristic, no common source of the outbreak was discovered.…”

Section: Clinical Significancementioning

confidence: 99%

Classification, Identification, and Clinical Significance ofProteus,Providencia, andMorganella

O'Hara¹,

Brenner

Miller³

2000

Clin Microbiol Rev

384

238

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SUMMARY This review presents the current taxonomy of the genera Proteus, Providencia, and Morganella, along with the current methods for the identification of each species within the three genera, incorporating both conventional biochemical and commercial methods. While all of these organisms are ubiquitous in the environment, individual case reports and nosocomial outbreak reports that demonstrate their ability to cause major infectious disease problems are presented. Lastly, anticipated antimicrobial susceptibility patterns are reviewed. Many of these organisms are easily controlled, but the advent of newer and more powerful antimicrobial agents has led to some problems of which laboratorians need to be aware.

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“…Antibiotic-resistant Proteus rettgeri and Providencia stuartii have been shown in recent years to be the causes of serious nosocomial disease (7,11,15,(23)(24)(25). Numerous serologically different strains occur among these species and, in our laboratory, the number of 0-specificities had been noted to increase as isolates from different sources were examined.…”

mentioning

confidence: 70%

“…The use of immunotherapy for protection against these bacteria has not been investigated as has been the case for Pseudomonas aeruginosa (1-3, 5, 9, 10, 12). Previous studies on P. rettgeri and P. stuartii have shown considerable differences in virulence among strains (7,23,24), but relationships between virulence and the 0 antigens were not demonstrated. Since schemes for discriminating among strains of these proteeae have been described (20,21), further studies on their virulence and the mechanisms of immunity to these bacteria were clearly indicated.…”

mentioning

confidence: 77%

Cross-protection of mice provided by active and passive immunization against experimental infections with virulent Proteus rettgeri and Providencia bacteria

Penner¹,

Whiteley²

1978

Infect Immun

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Immunization with Providencia and Proteus rettgeri Formalin-treated bacterial suspensions produced high levels of protection in mice against homologous and heterologous challenge. Mice were also cross-protected, but less effectively, by passive administration of rabbit type-specific antisera. The protective activity appeared to be due to an antigen common to strains of different 0-serotypes. It was not detectable in agglutination reactions, and preliminary results indicate that it is thermostable, not being inactivated in its antibody binding capacity at 121°C for 1 h.

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Characterization of an Unusual Strain of Proteus rettgeri Associated with an Outbreak of Nosocomial Urinary-Tract Infection

Cited by 14 publications

References 16 publications

Numerical analysis of electrophoretic protein patterns of Providencia rettgeri strains from human faeces, urine and other specimens

Numerical analysis of electrophoretic protein patterns of Providencia rettgeri strains from human faeces, urine and other specimens

Classification, Identification, and Clinical Significance ofProteus,Providencia, andMorganella

Cross-protection of mice provided by active and passive immunization against experimental infections with virulent Proteus rettgeri and Providencia bacteria

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