Characterization of ankylosing spondylitis in Upper Egypt

Moshrif, A.; Mosallam, Ahmed; Rayan, Mohamed Moneer; Sobhy, Hamid Khalifa Ali

doi:10.4172/1758-4272.1000162

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…The mean BASDAI and BASFI were 4.8 ± 1.18 and 5.4 ± 1.5, respectively. Axial radiographic damage was significantly greater in men [22].…”

Section: Short Communicationmentioning

confidence: 83%

Gender differences in ankylosing spondylitis patients: Relation to clinical characteristics, functional status and disease activity

Haroon¹,

Gheita²

2018

Int. J. Clin. Rheumatol

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To assess gender differences in Ankylosing Spondylitis (AS) patients regarding the clinical presentation, disease activity and functional status. Methods and findings: Forty AS patients; 21 males and 19 females, regularly following at the Rheumatology outpatient's clinic, Saudi German Hospital, Riyadh, KSA were included. Functional status and the disease activity were evaluated using Bath Ankylosing Spondylitis Functional Index (BASFI) and the Bath AS Disease Activity Index (BASDAI) respectively. Mean age was 34.3 ± 8.5 years with a comparable sex ratio (M:F 1.11:1). Morning stiffness was markedly lower in females (72.4 ± 52.4 vs 112.9 ± 44.4 minutes) (p=0.01).Bilateral sacroiliitis was significantly more in males (n=18; 85.7% vs n=13; 68.4%) (p=0.02).The Schöber's test was more limited and the finger-to-floor distance more increased in males (4.5 ± 0.8 cm and 40.7 ± 9.2 cm vs 4.9 ± 0.7 cm and 27.9 ± 9.7 cm; p=0.046 and p<0.001 respectively). Human leukocytic antigen-B27) was positive in 85.7% of males while rheumatoid factor was positive in only 3 females. BASFI showed significantly higher value in females (6.7 ± 1.1 vs 5.8 ± 1.4) (p=0.04), while BASDAI showed only a tendency to be higher in females. Using Magnetic resonance imaging of the sacroiliac joint, sacroiliitis was detected in all cases with signs of activity in 9 males and 7 females, erosions in 8 males and 5 females, effusion in 1 female and total ankylosis in 1 male. Conclusion: The clinical presentation and genetic background were more remarkable in the AS males; however the disease activity and functional impairment were increased in females. Radiological findings were comparable.Understanding the gender differences in AS may discern how this may impact future research, diagnosis and treatment.

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“…The mean BASDAI and BASFI were 4.8 ± 1.18 and 5.4 ± 1.5, respectively. Axial radiographic damage was significantly greater in men [22].…”

Section: Short Communicationmentioning

confidence: 83%

Gender differences in ankylosing spondylitis patients: Relation to clinical characteristics, functional status and disease activity

Haroon¹,

Gheita²

2018

Int. J. Clin. Rheumatol

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“…In our study, four patients (16%) had syndesmophytes, five (20%) had loss of lumbar lordosis, four (16%) had vertebral squaring, and two (8%) had bamboo spine. In a study done by Moshrif et al ,[ 25 ] vertebral squaring was seen in 49 patients (70%), lumbar syndesmophytes in 45 (64.3%), cervical syndesmophytes in 35 (50%), bamboo spine in 13 (18.6%) patients.…”

Section: Discussionmentioning

confidence: 97%

A study of clinical, radiological features and HLA-B27 serology of axial spondyloarthropathy with comparison of radiographic and non-radiographic disease

Bhatt

Edara

Zanwar

et al. 2022

Journal of Family Medicine and Primary Care

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Background: Axial spondyloarthropathy is a type of disease which affects the axial skeleton affecting productive years. Methods: This was a cross-sectional, observational study in which 28 consecutive patients more than 16 years of age, fulfilling the Assessment of SpondyloArthritis International Society (ASAS) criteria for axial spondyloarthropathy were included. They were further sub-grouped into radiographic and non-radiographic axial spondyloarthropathy. Clinical features, joint involvement, measurements, HLA-B27 serology, and disease activity were evaluated. Data was entered into Microsoft Excel, and SPSS (Statistical Package for Social Sciences) software 2.0 was used for analyzing the data. Results: Mean age was 28.5 ± 6.3 years. 85.7% were males. Inflammatory low back pain was the most common clinical feature at presentation (89.2%). Enthesitis was the most common extra-articular feature seen in 35.7% of patients. 42.8% were non-radiographic axial spondyloarthritis. 85.7% of patients were HLA-B27 positive. 50% of patients had bone marrow edema on MRI, and only one patient had ankylosis indicating predominantly early disease. 50%–70% of our patients had high disease activity and 89.3% were responding well to non-steroidal anti-inflammatory drugs (NSAIDs). There was no significant difference between the radiographic axial spondyloarthritis group and the non-radiographic group except for elevated C-reactive protein (CRP). Conclusion: Ankylosing spondylitis in western India occurs mostly in the age group of 20–30 years, suggesting affection of productive age group. There was a delay of diagnosis for approximately three years from the onset of symptoms. There was a positive association with HLA-B27 in majority of the patients. Most of our patients had early disease based on radiological findings, suggesting that there was room for therapeutic intervention before irreversible ankylosis had set in.

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“… 18 Moshrif et al observed a comparable DD for ankylosing spondylitis with an average of 9 years in Egyptian patients. 19 Delays in FM diagnosis have been attributed to a greater economic burden, increased healthcare demand, and poor treatment response. 20 , 21 However, its influence on patient symptomatology and disease severity remains underappreciated.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effect of Delayed Diagnosis on Disease Outcome in Fibromyalgia: A Multi-Center Cross-Sectional Study

Moshrif¹,

Mosallam²,

Abu-Zaid³

et al. 2023

JPR

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Background The impact of delayed diagnosis (DD) on fibromyalgia (FM) patients’ symptomatology and disease outcome has not yet been systematically studied. Objective To analyze the predictors of DD and the influence of DD on FM aggravation and disease evaluation measures. Methods 370 FM patients were interviewed prospectively for this study. The following information was obtained: DD, widespread pain index (WPI), symptom severity scale (SSS), polysymptomatic distress scale (PDS) scale (SSS + WPI), and tender points. We identified three groups of patients: early diagnosis (ED: 2 years; 83 patients), late diagnosis (LD: > 2–7 years; 198 patients), and very late diagnosis (VLD: > 7 years; 89 patients). Results The patients’ average age was 33.9 (9.8) years, and 79% were female. The SSS, PDS, and tender point means were 7.8 (1.6), 16.46 (4.1), and 14.31 (2.3), respectively. The correlation between DD and SSS (r = 0.14), the PDS scale (r = 0.37), and FM tender points (r = 0.16) was significant, but not with WPI (r = 0.06). When the three groups were examined, the SSS mean was 7.54 (1.6), 7.73 (1.4), and 8.25 (1.7), respectively (P 0.008), while the PDS mean was 15 (3.8), 15.95 (3.8), and 18.96 (4.4), respectively (P 0.008). (P 0.001). Conclusion Early FM diagnosis is associated with lower SSS, total severity scale, and FM tender points, indicating a less severe condition.

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Characterization of ankylosing spondylitis in Upper Egypt

Cited by 7 publications

References 27 publications

Gender differences in ankylosing spondylitis patients: Relation to clinical characteristics, functional status and disease activity

Gender differences in ankylosing spondylitis patients: Relation to clinical characteristics, functional status and disease activity

A study of clinical, radiological features and HLA-B27 serology of axial spondyloarthropathy with comparison of radiographic and non-radiographic disease

Evaluating the Effect of Delayed Diagnosis on Disease Outcome in Fibromyalgia: A Multi-Center Cross-Sectional Study

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