Characterization of antibacterial bacterial cellulose composite membranes modified with chitosan or chitooligosaccharide

Yin, Nan; Du, Renpeng; Zhao, Fangkun; Han, Yongdian

doi:10.1016/j.carbpol.2019.115520

Cited by 104 publications

(47 citation statements)

References 45 publications

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“…As seen in Fig. 3A, three peaks at 14.2 • , 16.6 • , and 22.6 • are observed, which are characteristic peaks of cellulose I [35]. There is a broad peak centered at around 22.6 • in the XRD pattern of CA, which is consistent with previous reports [36,37].…”

Section: Characterization Of Ca/bnc-h Graftssupporting

confidence: 91%

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Zhang

Zhu

et al. 2021

Materials Science and Engineering: C

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Constructing biomimetic structure and immobilizing antithrombus factors are two effective methods to ensure rapid endothelialization and long-term anticoagulation for small-diameter vascular grafts. However, few literatures are available regarding simultaneous implementation of these two strategies. Herein, a nano-micro-fibrous biomimetic graft with a heparin coating was prepared via a step-by-step in situ biosynthesis method to improve potential endothelialization and anticoagulation. The 4-mm-diameter tubular graft consists of electrospun cellulose acetate (CA) microfibers and entangled bacterial nanocellulose (BNC) nanofibers with heparin coating on dual fibers. The hybridized and heparinized graft possesses suitable pore structure that facilitates endothelia cells adhesion and proliferation but prevents infiltration of fibrous tissue and blood leakage. In addition, it shows higher mechanical properties than those of bare CA and hybridized CA/BNC grafts, which match well with native blood vessels. Moreover, this dually modified graft exhibits improved blood compatibility and endothelialization over the counterparts without hybridization or heparinization according to the testing results of platelet adhesion, cell morphology, and protein expression of von Willebrand Factor. This novel graft with dual modifications shows promising as a new small-diameter vascular graft. This study provides a guidance for promoting endothelialization and blood compatibility by dual modifications of biomimetic structure and immobilized bioactive molecules.

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Section: Characterization Of Ca/bnc-h Graftssupporting

confidence: 91%

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Zhang

Zhu

et al. 2021

Materials Science and Engineering: C

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“…Chitosan is biocompatible, nontoxic, and also has biodegradable proprieties, hence it is broadly studied in many fields [17]. It has been explored for its antibacterial activity against Gram-positive and Gram-negative bacteria [18,19]. Different mechanisms have been proposed for the antimicrobial activity of chitosan, such as the perturbation of ion transport on the microorganisms [19,20].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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The global rise of infectious disease outbreaks and the progression of microbial resistance reinforce the importance of researching new biomolecules. Obtained from the hydrolysis of chitosan, chitooligosaccharides (COSs) have demonstrated several biological properties, including antimicrobial, and greater advantage over chitosan due to their higher solubility and lower viscosity. Despite the evidence of the biotechnological potential of COSs, their effects on trypanosomatids are still scarce. The objectives of this study were the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of COSs. NMR and mass spectrometry analyses indicated the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no evidence of cytotoxicity upon 2 mg/mL. In addition, COSs showed interesting activity against bacteria and yeasts and a time-dependent parasitic inhibition. Scanning electron microscopy images indicated a parasite aggregation ability of COSs. Thus, the broad biological effect of COSs makes them a promising molecule for the biomedical industry.

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“…Although this methodology often allows to develop efficient biomaterials through easy processes, there are a few drawbacks related to the use of leachable agents, such as the maximum amount that can be loaded into the matrix, the stability of low molecular weight compounds, which are often characterized by higher reactivity and volatility (for instance, in the case of antibacterial natural compounds) and the short-term activity, which is dependent on the release profile of such agents ( Giano et al, 2014 ; Deka et al, 2015 ). Another strategy for the development of BC-based antibacterial materials involves the combination of BC with antibacterial polymers such as chitosan ( Lin et al, 2013 ; Kingkaew et al, 2014 ; Wahid et al, 2019b ; Yin et al, 2020 ) and ε-polylysine ( Gao et al, 2014 ). In this case, however, it is fundamental to ensure good compatibility between the two components to avoid phase separation.…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Orlando

Basnett

Nigmatullin

et al. 2020

Front. Bioeng. Biotechnol.

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Characterization of antibacterial bacterial cellulose composite membranes modified with chitosan or chitooligosaccharide

Cited by 104 publications

References 45 publications

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

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