Characterization of Antifungal Metabolites Produced by Aeromonas Hydrophila and Analysis of its Chemical Compounds Using GC-MS

Kamal, Sabreen A.; Hamza, Lena Fadhil; Ibraheam, Israa Adnan

doi:10.5958/0974-360x.2017.00697.7

Cited by 8 publications

(5 citation statements)

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“…The following compounds were present in this species: the anti-cancer compounds reported in Table 4, such as linalool [11]; cyanoacetylurea [39]; imidazole, 2-amino-5-[(2-carboxy)vinyl]- [53]; pterin-6-carboxylic acid [65]; quinoline, 4-methyl-, 1-oxide [70]; anti-microbial compounds, including 1-octen-3-ol [13]; 2-isopropoxyethylamine [19]; arginine [25]; endoborneol [46]; and imidazole, 2-amino-5-[(2-carboxy) vinyl]- [52]. The anti-viral compounds, including 2-furanmethanol, 5-ethenyltetrahydro-.α., .α.,5-trimethyl-, cis [16]; cyanoacetylurea [40]; pterin-6-carboxylic acid [65]; anti-oxidant compounds, such as 2-furanmethanol, 5-ethenyltetrahydro-.α., .α.,5-trimethyl-, cis [16]; folic Acid [50]; pterin-6-carboxylic acid [67]; anti-inflammatory, such as linalool [11], imidazole, 2-amino-5-[(2-carboxy)vinyl]- [52]; bicyclo[2.2.1] heptan-2-one, 4,7,7-trimethyl-, semicarbazone [34]; pterin-6-carboxylic acid [67]. Meanwhile, the antimalaria compound 8-amino-6-methoxyquinoline [21] was found in the analysis of P. lanceolata essential oil.…”

Section: Discussionmentioning

confidence: 99%

“…To treat bronchiolitis, [32] and anaphylaxis [33] Bicyclo[2.2.1]heptan-2-one, 4,7,7-trimeth-yl-, semicarbazone Anti-candida, anti-inflammatory activities [34] 3,4-Methylenedioxyamphetamine An empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family, as a recreational drug [35] (+)-Norpseudo-ephedrine / Cathine Cathine and norephedrine, phenylpropanol-amines structurally related to amphetamine [36] 3-Methoxyamphetamine A designer drug alternative to MDMA [37] Cyanoacetylurea As a starting material for the synthesis of a variety of heterocycles1 is easily prepared from low-cost materials [38], a key intermediate in the synthesis of 6-aminouracils, which possess several biological activities such as anti-cancer [39], anti-viral [40], anti-hypertensive [41], insecticidal, herbicidal, acaricidal activities [42] Metanephrine Inactive metabolite of epinephrine [43] Desmethyldoxepin Anti-depressant properties [44] Mexiletine Anti-arrhythmic activity [45] endo-Borneol Anti-bacterial, anti-fungal activities [46] Benzenemethanol, alpha.-(1-aminoethyl)-2,5dimethoxy-/ Methoxamine A blood-pressure increasing drug commonly used for maintaining intraoperative hemodynamics [47] 4-Fluorohistamine Substrate for several enzymes and inhibitor for histidine ammonia lyase [48] Actinobolin Antibiotic, antitumor, antibacterial [49] Library/ID -(Plan-tago Lanceolata)…”

Section: Epinephrinementioning

confidence: 99%

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Volatile Constituents and Toxicity of Essential Oils Extracted From Aerial Parts of Plantago Lanceolata and Plantago Major Growing in Iran

Haghighi¹,

Yazdinezhad²,

Bagheri³

et al. 2022

PBR

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Background:Plantago lanceolata L. (P. lanceolate) and Plantago major L. (P. major) belong to the Plantaginaceae family and are widely used in traditional medicine. Objectives: This study aims to qualitatively identify the crucial compounds and evaluate the toxicity effects of essential oils of two Plantago species. Methods: The plantains were collected from Zanjan Province, Iran. The essential oils were extracted by hydrodistillation and then analyzed using gas chromatography coupled with mass spectrometry (GC/MS). The toxicity effects of the essential oils were evaluated on HCT-116 and HEK-293 cell lines (in vitro MTT assay) and Artemia salina (A.salina) (in vivo assay). The constituents of the essential oils were identified by calculating their retention indices under temperature-programmed conditions for n-alkanes (C8 -C20) in the Agilent 19091S-433 column. Results: The main identified constituents were metaraminol (14.04%), bifemelane (8.73%), metossamina (8.16%), and pterin-6-carboxylic acid (5.11%) in P. lanceolata and 2-dodecen-1-yl (-) succinic anhydride (15.29%), benzenemethanol, α-(1-aminoethyl)-2,5- dimethoxy-(11.83%), dl-phenylephrine (7.51%), and nortriptyline (5.15%) in P. major. The essential oils of P. major exhibited more antiproliferative properties on HCT-116 at 72 h compared to P. lanceolata (IC50: 102.66 µg/mL). At 400 µg/mL of P. lanceolata and P. major, the percentage of the lethality of nauplii was 8% and 12%, respectively (LC50:2242.57 µg/ mL and 1783.7 µg/mL). The present study showed that the most of constituents of oils were alcohols and amines. Conclusion: Some of the compounds identified in the Plantago species essential oils have important pharmaceutical properties. This study reported the cytotoxicity of essential oils on the colon cancer cell line. However, the essential oils were not toxic against A.salina at the examined concentrations.

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Section: Discussionmentioning

confidence: 99%

Section: Epinephrinementioning

confidence: 99%

Volatile Constituents and Toxicity of Essential Oils Extracted From Aerial Parts of Plantago Lanceolata and Plantago Major Growing in Iran

Haghighi¹,

Yazdinezhad²,

Bagheri³

et al. 2022

PBR

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“…Methanol was used as solvent control. Amphotericin B and fluconazole were used as reference antifungal agent [36][37][38][39][40][41][42][43][44][45][46][47] . The tests were carried out in triplicate.…”

Section: Determination Of Antibacterial and Antifungal Activitymentioning

confidence: 99%

Screening of Metabolites Products of Fusarium oxysporum and Determination of Its Antibacterial and Antifungal Activity Using Medicinal Plants Extract

Al-Rubaye¹,

Hameed²,

Kamal³

2018

Ind. Jour. of Publ. Health Rese. & Develop.

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The aims of this study were screening of the secondary metabolite products and evaluation antimicrobial activity. Bioactives are chemical compounds often referred to as secondary metabolites. Twenty one bioactive compounds were identified in the methanolic extract of Fusarium oxysporum. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. Melissa officinalis was very highly active 6.470±0.25 mm. The results of anti-fungal and anti-bacterial activity produced by Fusarium oxysporum showed that the volatile compounds were highly effective to suppress the growth of Aspergillus fumigatus (5.893±0.20) and Streptococcus pyogenes (6.001±0.19). Based on the significance of employing bioactive compounds in pharmacy to produce drugs for the treatment of many diseases, the purification of compounds produced by Fusarium oxysporum can be useful.

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“…However, very few studies have investigated the biosynthetic capacity of this group of microorganisms. The presence of secondary metabolites has been recognized in various Aeromonas species [2] such as Aeromonas hydrophila , in which GC-MS analysis suggests the presence of 23 antifungal bioactive compounds [3]. Aeromonas salmonicida subsp.…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom

et al. 2019

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Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.

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Characterization of Antifungal Metabolites Produced by Aeromonas Hydrophila and Analysis of its Chemical Compounds Using GC-MS

Cited by 8 publications

References 0 publications

Volatile Constituents and Toxicity of Essential Oils Extracted From Aerial Parts of Plantago Lanceolata and Plantago Major Growing in Iran

Volatile Constituents and Toxicity of Essential Oils Extracted From Aerial Parts of Plantago Lanceolata and Plantago Major Growing in Iran

Screening of Metabolites Products of Fusarium oxysporum and Determination of Its Antibacterial and Antifungal Activity Using Medicinal Plants Extract

Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom

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