Characterization of attenuation and respiratory motion artifacts and their influence on SPECT MP image evaluation using a dynamic phantom assembly with variable cardiac defects

Chrysanthou-Baustert, Isabelle; Polycarpou, Irene; Demetriadou, Ourania; Livieratos, Lefteris; Lontos, Antonis; Antoniou, A.; Christofides, Stelios; Yiannakkaras, Charalambos; Kaolis, Demetris; Panagidis, Christoforos; Marsden, Paul; Parpottas, Yiannis

doi:10.1007/s12350-015-0378-y

Cited by 18 publications

(17 citation statements)

References 15 publications

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“…This also concerns decisions regarding motion, pulsatile flow and perfusion deficit simulation. For example, in myocardial perfusion modelling it could be relevant to incorporate respiratory and cardiac motion for certain analyses [47,48], while for other tissues "motion" could be disregarded more easily.…”

Section: Discussionmentioning

confidence: 99%

Quantitative imaging: systematic review of perfusion/flow phantoms

et al. 2020

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Background: We aimed at reviewing design and realisation of perfusion/flow phantoms for validating quantitative perfusion imaging (PI) applications to encourage best practices. Methods: A systematic search was performed on the Scopus database for "perfusion", "flow", and "phantom", limited to articles written in English published between January 1999 and December 2018. Information on phantom design, used PI and phantom applications was extracted. Results: Of 463 retrieved articles, 397 were rejected after abstract screening and 32 after full-text reading. The 37 accepted articles resulted to address PI simulation in brain (n = 11), myocardial (n = 8), liver (n = 2), tumour (n = 1), finger (n = 1), and non-specific tissue (n = 14), with diverse modalities: ultrasound (n = 11), computed tomography (n = 11), magnetic resonance imaging (n = 17), and positron emission tomography (n = 2). Three phantom designs were described: basic (n = 6), aligned capillary (n = 22), and tissue-filled (n = 12). Microvasculature and tissue perfusion were combined in one compartment (n = 23) or in two separated compartments (n = 17). With the only exception of one study, inter-compartmental fluid exchange could not be controlled. Nine studies compared phantom results with human or animal perfusion data. Only one commercially available perfusion phantom was identified. Conclusion: We provided insights into contemporary phantom approaches to PI, which can be used for ground truth evaluation of quantitative PI applications. Investigators are recommended to verify and validate whether assumptions underlying PI phantom modelling are justified for their intended phantom application.

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Section: Discussionmentioning

confidence: 99%

Quantitative imaging: systematic review of perfusion/flow phantoms

et al. 2020

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“…A nuclear medicine physician visually evaluated the reconstructed polar maps. As in previous phantom and patient studies [2,18,19], motion artifacts were induced in the anterior and inferior myocardial walls. However, in prone imaging, the diaphragmatic attenuation in the inferior wall was reduced [18,19].…”

Section: Discussionmentioning

confidence: 67%

“…In our previous studies [2,3,[10][11][12], we acquired SPECT/CT images using an anthropomorphic thorax which enclosed moving thoracic compartments: (a) a cardiac phantom of an ECG beating and moving left ventricle during respiration in the cranio-caudal direction, and (b) a breathing phantom of a pair of lungs. These motions could be controlled in time interval of 0.1 sec and various parameters of the motions can vary such as the ejection fraction, heart rate, breath rate and tidal volume.…”

Section: Introductionmentioning

confidence: 99%

A Moving Liver Phantom in An Anthropomorphic Thorax for SPECT MP Imaging

Panagi¹,

Hadjiconstanti²,

Charitou³

et al. 2021

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Cranio-caudal respiratory motion and liver activity cause a variety of complex myocardial perfusion (MP) artifacts, especially in the inferior myocardial wall, that may also mask cardiac defects. To assess and characterize such artifacts, an anthropomorphic thorax with moving thoracic phantoms can be utilized in SPECT MP imaging. In this study, a liver phantom was developed, and anatomically added into an anthropomorphic phantom, that encloses an ECG beating cardiac phantom and breathing lungs phantom. A cranio-caudal respiratory motion was also developed for the liver phantom and it was synchronized with the corresponding ones of the cardiac and lungs phantoms. This continuous motion could also be further divided into dynamic respiratory phases, from end-exhalation to end-inspiration, to perform SPECT acquisitions in different respiratory phases. The motion parameters, displacements and volumes, were validated by the acquired CT slices, the OsiriX and Vitrea software. Sample SPECT/16-slice-CT myocardial MP acquisitions were also performed and compared to the literature. The cardiac, lungs and liver phantoms can precisely perform, in time interval of 0.1 sec, physiological thoracic motions within an anthropomorphic thorax. This dynamic phantom assembly can be utilized for SPECT MP supine and, for first time, prone imaging to access and characterize artifacts due to different cranio-caudal respiratory amplitudes and cardiac-liver activity ratios.

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“…Several factors can affect the results of the analysis and the value of the studies. This is true for all modalities and in the case of SPECT MPI, [31][32][33][34][35] which is the subject of this study, it is crucial to ensure that the acquisition and reconstruction parameters are consistent and optimized, thus allowing accurate and reproducible results.…”

Section: Discussionmentioning

confidence: 99%