2020
DOI: 10.1101/2020.06.17.157479
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Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior

Abstract: The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role of individual BF subtypes is still being uncovered. Glutamatergic neurons are the least wellunderstood of the three major BF neurotransmitter phenotypes. Here we analyzed the distribution, size, calcium-binding protein content and projections of the major group of BF glutamate neurons expressing the vesicular glutamate transporter subtype 2 (vGluT2) and tested the functional effect of activating them. Mice expressing… Show more

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Cited by 1 publication
(3 citation statements)
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“…The VGLUT2-Cre group exhibited a significantly higher locomotion speed (Fig. 5D), which was consistent with the wakefulness and avoidance behavior-promoting effect of BF VGLUT2 neurons 3,15,16 . The ChAT-Cre group demonstrated significantly higher novel object explorations (Fig.…”
Section: Inhibitory (Pv and Som) Or Excitatory (Vglut2 And Chat) Neur...supporting
confidence: 78%
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“…The VGLUT2-Cre group exhibited a significantly higher locomotion speed (Fig. 5D), which was consistent with the wakefulness and avoidance behavior-promoting effect of BF VGLUT2 neurons 3,15,16 . The ChAT-Cre group demonstrated significantly higher novel object explorations (Fig.…”
Section: Inhibitory (Pv and Som) Or Excitatory (Vglut2 And Chat) Neur...supporting
confidence: 78%
“…1E, upper panel) and corresponding highest locomotion speed (Fig. 5D) of BF VGLUT2 group possibly attribute to the promoting wakefulness and avoidance behavior effects of BF VGLUT2 neurons 3,14,15 . The activation of the PFC, Mot, SS, AUD, VIS, and striatum (Fig.…”
Section: Discussionmentioning
confidence: 91%
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