Characterization of behavioral and endocrine effects of LSD on zebrafish

Grossman, Leah; Utterback, Eli; Stewart, Adam; Gaikwad, Siddharth; Chung, Kyung Min; Suciu, Christopher; Wong, Keith; Elegante, Marco; Elkhayat, Salem; Tan, Julia; Gilder, Thomas; Wu, Nadine; DiLeo, John; Cachat, Jonathan; Kalueff, Allan V.

doi:10.1016/j.bbr.2010.05.039

Cited by 217 publications

(188 citation statements)

References 71 publications

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“…Two studies have now been published describing the effects of psychedelics on zebrafish. Grossman et al (2010) characterized the behavioral and endocrine effects of LSD on adult zebrafish. Behavioral paradigms used were novel tank, observation cylinder, light/dark box, open field, T-maze, social preference, and shoaling tests.…”

Section: Zebrafish Modelsmentioning

confidence: 99%

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Psychedelics

2016

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Section: Zebrafish Modelsmentioning

confidence: 99%

“…Behavioral paradigms used were novel tank, observation cylinder, light/dark box, open field, T-maze, social preference, and shoaling tests. The tests are all described in detail in Grossman et al (2010). Video-tracking tools were used, and whole-body cortisol was measured.…”

Section: Zebrafish Modelsmentioning

confidence: 99%

Psychedelics

2016

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“…63 These studies have developed detailed 3D-based approaches to phenotyping of zebrafish motor and anxiety-related behaviors, offering an innovative high-throughput data-dense methodology for automated visualization and quantification of fish swimming activity in both X, Y, Z (spatial) and X, Y, Time (spatiotemporal) coordinates. The use of 3D reconstruction of movement patterns (see Figure 1 for example) to study hallucinogenic drugs 66,70 enables a more precise deconstruction of zebrafish behavior affected by various agents. As rodent models used in neurobehavioral research are mainly based on 2D movement, zebrafish paradigms offer an increased dimensionality of behavioral phenotyping.…”

Section: ■ Future Directions: Where Next?mentioning

confidence: 99%

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Neelkantan

Mikhaylova

Stewart

et al. 2013

ACS Chem. Neurosci.

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Among different classes of psychotropic drugs, hallucinogenic agents exert one of the most prominent effects on human and animal behaviors, markedly altering sensory, motor, affective, and cognitive responses. The growing clinical and preclinical interest in psychedelic, dissociative, and deliriant hallucinogens necessitates novel translational, sensitive, and high-throughput in vivo models and screens. Primate and rodent models have been traditionally used to study cellular mechanisms and neural circuits of hallucinogenic drugs' action. The utility of zebrafish (Danio rerio) in neuroscience research is rapidly growing due to their high physiological and genetic homology to humans, ease of genetic manipulation, robust behaviors, and cost effectiveness. Possessing a fully characterized genome, both adult and larval zebrafish are currently widely used for in vivo screening of various psychotropic compounds, including hallucinogens and related drugs. Recognizing the growing importance of hallucinogens in biological psychiatry, here we discuss hallucinogenic-induced phenotypes in zebrafish and evaluate their potential as efficient preclinical models of drug-induced states in humans.

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“…Fear is characterized by moving away from a current threat, whereas anxiety often occurs when there is movement towards a potential threat. Thus, while escape is likely to represent a fear response, zebrafish are clearly capable of more than this, and their complex anxiety-like behavior includes freezing, erratic movements, hypolocomotion, geo-, thigmo-and scototaxis (Grossman et al, 2010;Maximino et al, 2010a;Cachat et al, 2011;Stewart et al, 2011).…”

Section: W Hy Use Zebrafish For Neurobehavioral Research?mentioning

confidence: 99%

Time to recognize zebrafish ‘affective’ behavior

Vernier

Kyzar

Maximino

et al. 2012

Behav

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Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena. Here, we focus on to the growing spectrum of zebrafish behavioral phenotypes and the 'bigger' biological problems these models help to address. Emphasizing the developing potential of zebrafish as a model organism in biological psychiatry, we discuss several questions related to this field: Do zebrafish have 'emotional'-like behaviors? What are their neural circuits, biomarkers, and ontogenetic origins? And, finally, how can we use this knowledge to build translational bridges to understand human emotions, motivation and personality? Representing a joint effort of several established neurobehavioral laboratories, this article outlines the mounting evidence to support emotionality in zebrafish and other fishes. This conclusion is important to justify the validity of zebrafish 'affective' paradigms and their utility for basic/translational research of normal and pathological behaviors.

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Characterization of behavioral and endocrine effects of LSD on zebrafish

Cited by 217 publications

References 71 publications

Psychedelics

Psychedelics

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Time to recognize zebrafish ‘affective’ behavior

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