Characterization of benzodiazepine misuse and comorbidities in patients with alcohol use disorder

Lopez, Elodie; Jeanne, Guillaume; Lefort, Laure-Hélène; Autissier, Cécile; Picot, Marie‐Christine; Peyrière, Hélène; Donnadieu‐Rigole, Hélène

doi:10.1111/fcp.12678

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…Diazepam is the most widely used benzodiazepine drug in some countries. Although it is safer, benzodiazepine overdose can result in coma and death ( Chan et al, 2020 ; Lopez et al, 2021 ). A systematic review of human studies that examined the prevalence, patterns, correlations, causes, motivations, sources, and effects of benzodiazepine abuse was published.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

Zhang

Kou²,

Qin³

et al. 2022

Front. Pharmacol.

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Background: Diazepam is a classic benzodiazepine drug that has been widely used for disorders such as anxiety, sleep disorders, and epilepsy, over the past 59 years. The study of diazepam has always been an important research topic. However, there are few bibliometric analyses or systematic studies in this field. This study undertook bibliometric and visual analysis to ascertain the current status of diazepam research, and to identify research hotspots and trends in the past 10 years, to better understand future developments in basic and clinical research.Methods: Articles and reviews of diazepam were retrieved from the Web of Science core collection. Using CiteSpace, VOSviewer, and Scimago Graphica software, countries, institutions, authors, journals, references, and keywords in the field were visually analyzed.Results: A total of 3,870 publications were included. Diazepam-related literature had high volumes of publications and citations. The majority of publications were from the USA and China. The highest number of publications and co-citations, among the authors, was by James M Cook. Epilepsia and the Latin American Journal of Pharmacy were the journals with the most publications on diazepam and Epilepsia was the most frequently cited journal. Through a comprehensive analysis of keywords and references, we found that current research on diazepam has focused on its mechanism of action, application in disease, pharmacokinetics, risk, assessment, and management of use, status epilepticus, gamma-aminobutyric acid receptors (GABAR), intranasal formulation, gephyrin, and that ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) is the current research hotspot.Conclusion: Research on diazepam is flourishing. We identified research hotspots and trends in diazepam research using bibliometric and visual analytic methods. The clinical applications, mechanisms of action, pharmacokinetics, and assessment and management of the use of diazepam are the focus of current research and the development trend of future research.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

Zhang

Kou²,

Qin³

et al. 2022

Front. Pharmacol.

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“…Comme le traitement de courte durée par benzodiazépines s’est révélé bénéfique pour la prise en charge du sevrage de l’alcool, mais qu’il peut entraîner une dépendance 48 , il a été démontré que des personnes atteintes de TUA peuvent se retrouver en traitement prolongé par benzodiazépines, avec les effets négatifs qui en découlent 49 , 50 . C’est pourquoi, dans cette ligne directrice, nous rappelons qu’il faut limiter la durée des ordonnances de benzodiazépines chez les personnes atteintes de TUA pour faciliter la prise en charge du sevrage de l’alcool en présence d’un risque de problèmes graves liés au sevrage.…”

Section: Recommandationsunclassified

“…Cette recommandation convient aux milieux de soins communautaires et aux milieux de soins de courte durée. Nous avons établi que le degré de certitude des données probantes pour cette recommandation est élevé à partir de multiples méta-analyses et ERC ayant montré les préjudices liés aux benzodiazépines, au risque de leur utilisation à des fins non médicales et aux effets et événements indésirables graves déclarés, tels que chutes et blessures 49 , 50 . Nous avons établi que cette recommandation est forte compte tenu du consensus du comité de rédaction de la ligne directrice et des possibles préjudices connus des benzodiazépines chez les personnes atteintes ou non de TUA 49 , 50 .…”

Section: Recommandationsunclassified

Ligne directrice canadienne pour la prise en charge clinique de la consommation d’alcool à risque élevé et du trouble d’utilisation de l’alcool

Wood,

Bright,

Hsu

et al. 2024

CMAJ

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Résumé Contexte: Au Canada, on note que les équipes soignantes et les personnes qui bénéficieraient de soins ciblés connaissent peu les interventions fondées sur des données probantes pour la prise en charge clinique du trouble d’utilisation de l’alcool. Pour combler cette lacune, l’Initiative canadienne de recherche sur l’abus de substances a créé un comité national dans le but d’élaborer une ligne directrice pour la prise en charge clinique de la consommation d’alcool à risque élevé et du trouble lié à la consommation d’alcool. Méthodes: L’élaboration de cette ligne directrice s’est faite selon le processus ADAPTE, et est inspirée par une ligne directrice britanno-colombienne de 2019 pour le trouble lié à la consommation d’alcool. Un comité national de rédaction de la ligne directrice (composé de 36 membres de divers horizons, notamment des universitaires, des médecins, des personnes ayant ou ayant eu des expériences de consommation d’alcool et des personnes s’identifiant comme Autochtones ou Métis) a choisi les thèmes prioritaires, a passé en revue les données probantes et atteint un consensus relatif aux recommandations. Nous avons utilisé l’outil AGREE II (Appraisal of Guidelines for Research and Evaluation Instrument II) et les principes de divulgation des intérêts et de gestion des conflits lors du processus de rédaction des lignes directrices (Principles for Disclosure of Interests and Management of Conflicts in Guidelines) publiés en anglais par le Réseau international des lignes directrices (Guidelines International Network) pour nous assurer que la ligne directrice répondait aux normes internationales de transparence, de qualité élevée et de rigueur méthodologique. Nous avons évalué les recommandations finales à l’aide de l’approche GRADE (Grading of Recommendations Assessment, Development, and Evaluation). Les recommandations ont fait l’objet d’une revue externe par 13 spécialistes et parties prenantes d’ici et de l’étranger. Recommandations: La ligne directrice comprend 15 recommandations qui concernent le dépistage, le diagnostic, la prise en charge du sevrage et le traitement continu, y compris les interventions psychosociales, les pharmacothérapies et les programmes communautaires. Le comité de rédaction de la ligne directrice a reconnu la nécessité d’insister sur la sous-utilisation des interventions qui pourraient être bénéfiques et sur les modes de prescription et autres pratiques d’usage courant qui ne reposent pas sur des données probantes et pourraient aggraver les effets de la consommation d’alcool. Interprétation: La ligne directrice se veut une ressource à l’intention des médecins, des responsables des orientations politiques et des membres des équipes cliniques et autres, de même que des personnes, des familles et des communautés affectées par la consommation d’alcool. Ces recommandations proposent un cadre fondé sur des données probantes pour alléger le lourd fardeau du tr...

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“…We rated the certainty of evidence for this recommendation as high, based on multiple meta-analyses and RCTs showing the harms related to benzodiazepine use, potential for nonmedical use, and documentation of the serious adverse effects and events, including falls and injuries. 49 , 50 We rated this recommendation as strong, given guideline committee consensus and known possible harms of benzodiazepine use among people with and without AUD. 49 , 50 …”

Section: Recommendationsmentioning

confidence: 99%

“… 49 , 50 We rated this recommendation as strong, given guideline committee consensus and known possible harms of benzodiazepine use among people with and without AUD. 49 , 50 …”

Section: Recommendationsmentioning

confidence: 99%

Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder

Wood,

Bright,

Hsu

et al. 2023

CMAJ

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Background: In Canada, low awareness of evidence-based interventions for the clinical management of alcohol use disorder exists among health care providers and people who could benefit from care. To address this gap, the Canadian Research Initiative in Substance Misuse convened a national committee to develop a guideline for the clinical management of high-risk drinking and alcohol use disorder. Methods: Development of this guideline followed the ADAPTE process, building upon the 2019 British Columbia provincial guideline for alcohol use disorder. A national guideline committee (consisting of 36 members with diverse expertise, including academics, clinicians, people with lived and living experiences of alcohol use, and people who self-identified as Indigenous or Métis) selected priority topics, reviewed evidence and reached consensus on the recommendations. We used the Appraisal of Guidelines for Research and Evaluation Instrument (AGREE II) and the Guidelines International Network’s Principles for Disclosure of Interests and Management of Conflicts to ensure the guideline met international standards for transparency, high quality and methodological rigour. We rated the final recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool; the recommendations underwent external review by 13 national and international experts and stakeholders. Recommendations: The guideline includes 15 recommendations that cover screening, diagnosis, withdrawal management and ongoing treatment, including psychosocial treatment interventions, pharmacotherapies and community-based programs. The guideline committee identified a need to emphasize both underused interventions that may be beneficial and common prescribing and other practice patterns that are not evidence based and that may potentially worsen alcohol use outcomes. Interpretation: The guideline is intended to be a resource for physicians, policymakers and other clinical and nonclinical personnel, as well as individuals, families and communities affected by alcohol use. The recommendations seek to provide a framework for addressing a large burden of unmet treatment and care needs for alcohol use disorder within Canada in an evidence-based manner.

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Characterization of benzodiazepine misuse and comorbidities in patients with alcohol use disorder

Abstract: Background: Due to the frequent presence of anxious symptoms and sleep disorders, benzodiazepines (BZD) are often prescribed to patients with alcohol use disorder (AUD).

Cited by 5 publications

References 19 publications

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

Ligne directrice canadienne pour la prise en charge clinique de la consommation d’alcool à risque élevé et du trouble d’utilisation de l’alcool

Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder

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