Characterization of biofilms formed by Candida parapsilosis, C. metapsilosis, and C. orthopsilosis

Lattif, Ali Abdul; Mukherjee, Pranab K.; Chandra, Jyotsna; Swindell, Kim; Lockhart, Shawn R.; Diekema, Daniel J.; Pfaller, Michael A.; Ghannoum, Mahmoud A.

doi:10.1016/j.ijmm.2009.09.001

Cited by 82 publications

(55 citation statements)

References 12 publications

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“…Small variations in the metabolic activities of the biofilm formed on the polystyrene surface were detected between the C. parapsilosis complex isolates tested. The results probably reflect the physiological differences between the isolates and confirm the report by Lattif et al (2010) that all species of C. parapsilosis complex form equivalent biofilms.…”

Section: Discussionsupporting

confidence: 88%

Candida parapsilosis complex water isolates from a haemodialysis unit: biofilm production and in vitro evaluation of the use of clinical antifungals

Pires

Santos

Zaia

et al. 2011

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 88%

Candida parapsilosis complex water isolates from a haemodialysis unit: biofilm production and in vitro evaluation of the use of clinical antifungals

Pires

Santos

Zaia

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…parapsilosis is notorious for the ability to form biofilms on catheters and other implanted devices (Tumbarello et al, 2007), more so than the closely related species C. orthopsilosis and C. metapsilosis (Lattif et al, 2010). This may explain why in all cases of polyfungal infection the species identified in the catheter was C. parapsilosis and never C. orthopsilosis.…”

Section: Discussionmentioning

confidence: 99%

Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections

Barbedo

Vaz

Pais

et al. 2015

Journal of Medical Microbiology

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“…In particular, the study demonstrated that MFG displays diminished activity (Ͼ16 mg/liter) against C. parapsilosis mature biofilms grown on polystyrene substrate but increased activity (Ͻ0.5 mg/liter) against biofilms grown on central venous catheter sections (31). Finally, interstudy differences could be due to either differences in the biofilm models used or the distinct clumping and irregular appearance of C. parapsilosis blastospores embedded within a shallow biofilm matrix that results in an easily dissociated biofilm structure (51,52).…”

Section: Discussionmentioning

confidence: 99%

Species-Specific and Drug-Specific Differences in Susceptibility of Candida Biofilms to Echinocandins: Characterization of Less Common Bloodstream Isolates

Simitsopoulou

Peshkova

Tasina

et al. 2013

Antimicrob Agents Chemother

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e Candida species other than Candida albicans are increasingly recognized as causes of biofilm-associated infections. This is a comprehensive study that compared the in vitro activities of all three echinocandins against biofilms formed by different common and infrequently identified Candida isolates. We determined the activities of anidulafungin (ANID), caspofungin (CAS), and micafungin (MFG) against planktonic cells and biofilms of bloodstream isolates of C. albicans (15 strains), Candida parapsilosis (6 strains), Candida lusitaniae (16 strains), Candida guilliermondii (5 strains), and Candida krusei (12 strains) by XTT [2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] assay. Planktonic and biofilm MICs were defined as >50% fungal damage. Planktonic cells of all Candida species were susceptible to the three echinocandins, with MICs of <1 mg/liter. By comparison, differences in the MIC profiles of biofilms in response to echinocandins existed among the Candida species. Thus, C. lusitaniae and C. guilliermondii biofilms were highly recalcitrant to all echinocandins, with MICs of >32 mg/ liter. In contrast, the MICs of all three echinocandins for C. albicans and C. krusei biofilms were relatively low (MICs < 1 mg/ liter). While echinocandins exhibited generally high MICs against C. parapsilosis biofilms, MFG exhibited the lowest MICs against these isolates (4 mg/liter). A paradoxical growth effect was observed with CAS concentrations ranging from 8 to 64 mg/ liter against C. albicans and C. parapsilosis biofilms but not against C. krusei, C. lusitaniae, or C. guilliermondii. While nonalbicans Candida planktonic cells were susceptible to all echinocandins, there were drug-and species-specific differences in susceptibility among biofilms of the various Candida species, with C. lusitaniae and C. guilliermondii exhibiting profiles of high MICs of the three echinocandins.

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Characterization of biofilms formed by Candida parapsilosis, C. metapsilosis, and C. orthopsilosis

Cited by 82 publications

References 12 publications

Candida parapsilosis complex water isolates from a haemodialysis unit: biofilm production and in vitro evaluation of the use of clinical antifungals

Candida parapsilosis complex water isolates from a haemodialysis unit: biofilm production and in vitro evaluation of the use of clinical antifungals

Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections

Species-Specific and Drug-Specific Differences in Susceptibility of Candida Biofilms to Echinocandins: Characterization of Less Common Bloodstream Isolates

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