Characterization of biogenic hydroxyapatite derived from animal bones for biomedical applications

Ramesh, S.; Loo, Zi Zhen; Tan, C.Y.; Chew, W.J. Kelvin; Ching, Yern Chee; Tarlochan, Faris; Chandran, Hari; Krishnasamy, Sivakumar; Bang, L. T.; Sarhan, Ahmed A.D.

doi:10.1016/j.ceramint.2018.03.072

Cited by 121 publications

(76 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HA is typically produced from chemical reagents such as precipitation, microwave irradiation, sol-gel, hydrothermal process, ultrasound irradiation, electrodeposition and spray pyrolysis [2,[9][10]. However, chemical synthesis is costly, has complex synthesis method, time consuming and impurity incorporation [11]. Therefore, naturally-derived HA was studied.…”

Section: Introductionmentioning

confidence: 99%

Effect of pH condition during hydrothermal synthesis on the properties of hydroxyapatite from eggshell waste

Toibah

Misran

Shaaban

et al. 2019

JMES

View full text Add to dashboard Cite

Hydroxyapatite (HA) powders were synthesized using eggshell waste through hydrothermal method to develop bioceramics materials for medical applications. The effects of the pH conditions during the synthesis on the phase behaviour, crystallite size, crystallinity and morphology of as-synthesized ceramic powders were evaluated. The XRD patterns showed that HA was only the main phase present in the as-synthesized powder after being calcined at 400°C. However, EDX measurement detected the presence of Mg as trace elements which originated from the eggshell as starting materials. The crystallite size and crystallinity of the HA powders were increased when the powders were synthesized in acidic condition as compared to basic condition. FESEM images showed that HA powder with nano-sized rods and spherical morphologies were obtained from the powders that were synthesized at pH 5, while the powder particles synthesized at basic condition at pH 9 produced elongated rod-shape particles. The PSD results showed that the synthesized HA were in agglomerated form which were also confirmed by FESEM images.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of pH condition during hydrothermal synthesis on the properties of hydroxyapatite from eggshell waste

Toibah

Misran

Shaaban

et al. 2019

JMES

View full text Add to dashboard Cite

show abstract

“…The obtained results can be explained as follows according to the literature [10][11]13]. When the bone heated at 750 °C from 1 to 5 hours, there was structural destruction of raw bone following by the recrystallization of Ca, P components to form the HA phase.…”

Section: Fig 5 Xrd Patterns Of Bone Treated At 750 °C For Differentmentioning

confidence: 81%

“…%) organic compounds. Collagen is the leading organic compound present in the natural bone (95%), other organic compounds exist in small concentrations such as chondroitin sulfate, keratin sulfate and lipids [10,13]. So, the fibrous collagen and other organic compositions dispersed the X-ray radiations which result in broad peaks in the XRD diagram.…”

Section: Xrd Investigationmentioning

confidence: 99%

“…S. Ramesh et al have extracted natural hydroxyapatite from bovine, caprine and galline bones by thermal treatment from 600 °C to 1000 °C [10]. The study shows that the natural HA from bovine bone was proved to be stable in the range of temperature evaluated while those separated from caprine and galline showed phase instability with the appearance of tri-calcium phosphate (TCP) after heat treatment beyond 700 °C.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Extraction of pure hydroxyapatite from porcine bone by thermal process

Vương

Linh

2019

Metall Mater Eng

View full text Add to dashboard Cite

Natural hydroxyapatite (HA) has been extracted from porcine bone by thermal decomposition without any chemical treatment. The suitable condition to synthesize HA was chosen as a heating bone at 750 °C during 6 hours. XRD and FTIR analyses confirmed the high purity and crystallinity of synthetic HA. Furthermore, the transformation of the obtained HA to other phases did not mention up to 1200 °C. TG curve showed a slight loss of mass at 950 °C, but the DSC analysis did not present any physic-chemical phenomena during the period of measurement. FE-SEM images showed the different particles including spheres, scales, and rods in the structure of natural HA. EDX analysis indicated that the Ca/P ratio of the synthetic HA is 1.64, nearly the theoretical value of 1.67. Overall, the results obtained in this study confirmed the success of the thermal process to extract the natural HA from porcine bone.

show abstract

“…The viability of producing biogenic HA from bio-waste animal bones (bovine, caprine, and galline), by heat treatments in air atmosphere at different temperatures (600-1000 • C) was demonstrated by Ramesh et al [62]. Among the three types of investigated animal bones, it was demonstrated that the bovine-derived HA was stable for all investigated temperatures, while those produced from both caprine and galline bones exhibited signs of decomposition, with the appearance of the β-TCP phase at temperatures beyond 700 • C. In addition, the bovine and caprine bones presented hardness values comparable with the ones of the human cortical bone, while, for galline bone samples, higher porosity levels and low hardness values were inferred.…”

Section: Extraction Of Ha From Mammalian Bonesmentioning

confidence: 99%

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

Duta

Popescu

2019

Coatings

View full text Add to dashboard Cite

The aim of this paper is to present the current status on animal-origin hydroxyapatite (HA) coatings synthesized by Pulsed Laser Deposition (PLD) technique for medical implant applications. PLD as a thin film synthesis method, although limited in terms of surface covered area, still gathers interest among researchers due to its advantages such as stoichiometric transfer, thickness control, film adherence, and relatively simple experimental set-up. While animal-origin HA synthesized by bacteria or extracted from animal bones, eggshells, and clams was tested in the form of thin films or scaffolds as a bioactive agent before, the reported results on PLD coatings from HA materials extracted from natural sources were not gathered and compared until the present study. Since natural apatite contains trace elements and new functional groups, such as CO32− and HPO42− in its complex molecules, physical-chemical results on the transfer of animal-origin HA by PLD are extremely interesting due to the stoichiometric transfer possibilities of this technique. The points of interest of this paper are the origin of HA from various sustainable resources, the extraction methods employed, the supplemental functional groups, and ions present in animal-origin HA targets and coatings as compared to synthetic HA, the coatings’ morphology function of the type of HA, and the structure and crystalline status after deposition (where properties were superior to synthetic HA), and the influence of various dopants on these properties. The most interesting studies published in the last decade in scientific literature were compared and morphological, elemental, structural, and mechanical data were compiled and interpreted. The biological response of different types of animal-origin apatites on a variety of cell types was qualitatively assessed by comparing MTS assay data of various studies, where the testing conditions were possible. Antibacterial and antifungal activity of some doped animal-origin HA coatings was also discussed.

show abstract

Characterization of biogenic hydroxyapatite derived from animal bones for biomedical applications

Cited by 121 publications

References 43 publications

Effect of pH condition during hydrothermal synthesis on the properties of hydroxyapatite from eggshell waste

Effect of pH condition during hydrothermal synthesis on the properties of hydroxyapatite from eggshell waste

The Extraction of pure hydroxyapatite from porcine bone by thermal process

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

Contact Info

Product

Resources

About