Characterization of Biopolymer and Chitosan‐Based Nanocomposites with Antimicrobial Activity

Rhim, Jong‐Whan

doi:10.1002/9781118451915.ch19

Cited by 3 publications

(2 citation statements)

References 127 publications

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“…The plasma treated sample was immersed in 0.7% w / v concentration of chitosan solution and stirred for 10 h at room temperature. Due to the plasma treatment hydroxyl, carbonyl, and carboxyl groups were introduced onto the surface of UHMWPE fiber surfaces and enhanced the wettability of the surfaces [ 100 ]. It was believed that the amino groups of chitosan could be covalently bound to the surfaces of plasma treated UHMWPE by carboxyl groups to form amide bonds and increase strength [ 47 ].…”

Section: Methodologies For Surface Modification Of Uhmwpementioning

confidence: 99%

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

et al. 2022

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The selection of biomaterials as biomedical implants is a significant challenge. Ultra-high molecular weight polyethylene (UHMWPE) and composites of such kind have been extensively used in medical implants, notably in the bearings of the hip, knee, and other joint prostheses, owing to its biocompatibility and high wear resistance. For the Anterior Cruciate Ligament (ACL) graft, synthetic UHMWPE is an ideal candidate due to its biocompatibility and extremely high tensile strength. However, significant problems are observed in UHMWPE based implants, such as wear debris and oxidative degradation. To resolve the issue of wear and to enhance the life of UHMWPE as an implant, in recent years, this field has witnessed numerous innovative methodologies such as biofunctionalization or high temperature melting of UHMWPE to enhance its toughness and strength. The surface functionalization/modification/treatment of UHMWPE is very challenging as it requires optimizing many variables, such as surface tension and wettability, active functional groups on the surface, irradiation, and protein immobilization to successfully improve the mechanical properties of UHMWPE and reduce or eliminate the wear or osteolysis of the UHMWPE implant. Despite these difficulties, several surface roughening, functionalization, and irradiation processing technologies have been developed and applied in the recent past. The basic research and direct industrial applications of such material improvement technology are very significant, as evidenced by the significant number of published papers and patents. However, the available literature on research methodology and techniques related to material property enhancement and protection from wear of UHMWPE is disseminated, and there is a lack of a comprehensive source for the research community to access information on the subject matter. Here we provide an overview of recent developments and core challenges in the surface modification/functionalization/irradiation of UHMWPE and apply these findings to the case study of UHMWPE for ACL repair.

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Section: Methodologies For Surface Modification Of Uhmwpementioning

confidence: 99%

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

et al. 2022

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“…i ćelijskog zida gljiva. Hitozan je linearni polisaharid izgrađen od nasumice raspoređenih Dglukozamina i N -acetil -D -glukozamina povezanih β -(1→4) glikozidnom vezom [14][15][16][17][18][19].…”

Section: Uvodunclassified

Effect of tracers molecular weight on the release process from alginate microbeads

Ilić¹,

Grujic²,

Stijepovic³

et al. 2015

Tehnika

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U ovom radu je prikazan proces sinteze mikročestica od prirodnih polimera, alginata i hitozana, kao i neka njihova svojstva. Osnovna primena ovih mikročestica je da se koriste kao potencijalni nosači za aktivne supstance. U tom smislu je ispitivana i difuzija različitih supstanci iz njih. Na alginatne mikročestice dobijene metodom elektrostatičke ekstruzije vršena je apsorpcija tri trejserska indikatora sa različitim molekulskim masama: akridin oranž, plavi dekstran i metilensko plavo. Praćenjem kinetike otpuštanja indikatora iz mikročestica konstruisane su krive otpuštanja koje daju informaciju o uticaju veličine molekula svakog od indikatora na brzinu difuzije iz mikročestica. Da bi se postiglo što sporije otpuštanje indikatora alginatne mikročestice su oblagane hitozanom. Hitozan ima uticaj na smanjenje poroznosti gela, što dovodi do sporijeg otpuštanja trejsersikh indikatora iz mikročestica. Uporedna analiza dobijenih krivih otpuštanja daje odgovor o uticaju postupka dobijanja mikročestica na brzinu difuzije indikatora.

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Biofunctionalization of UHMWPE Polymer and Its Application in Anterior Cruciate Ligament Reconstruction

Wahed¹,

Dunstan²,

Boughton³

et al. 2020

Preprint

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The selection of biomaterials for biomedical application is a significant challenge. In the last few decades, various bioabsorbable and stable biopolymers have been applied for use as biomedical devices in orthopedic applications. Ultra-high molecular weight polyethylene (UHMWPE) has been extensively used in medical implants, notably in the bearings of hip, knee, and other joint prostheses, owing to its biocompatibility and high wear resistance. For the ACL graft, synthetic UHMWPE is an ideal candidate due to its biocompatibility and its extremely high tensile strength. Despite the appeal of new advanced materials such as carbon fiber, poly-ether-ether ketone, and other load-bearing materials, UHMWPE remains a primary load-bearing candidate material for ACL reconstructions because of its extremely high strength, the simplicity of the fabrication process, its biocompatibility, and low friction. However, some significant problems are observed in UHMWPE based implants, such as wear debris, and oxidative degradation due to the generation of free radicals when exposed to irradiation with gamma rays for grafting or sterilization. Various innovative methodologies have been developed to resolve those problems and enhance the properties of UHMWPE. In this review, we will explore in detail the methods for surface functionalization of UHMWPE and will apply these findings to the case study of UHMWPE for Anterior Cruciate Ligament repair.

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Characterization of Biopolymer and Chitosan‐Based Nanocomposites with Antimicrobial Activity

Cited by 3 publications

References 127 publications

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

Effect of tracers molecular weight on the release process from alginate microbeads

Biofunctionalization of UHMWPE Polymer and Its Application in Anterior Cruciate Ligament Reconstruction

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