Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis

Bauer, Natali; Khassawna, Thaqif El; Goldmann, Fee; Stirn, Martina; David, Lior; Schlewitz, Gudrun; Govindarajan, Parameswari; Zahner, Daniel; Weisweiler, David; Schliefke, Nathalie; Böcker, Wolfgang; Schnettler, Reinhard; Heiß, Christian; Moritz, Andreas

doi:10.1016/j.etp.2015.01.004

Cited by 12 publications

(16 citation statements)

References 51 publications

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“…Based on recent animal model data, BTMs can be used to differentiate early and late stages of primary or secondary osteoporosis [27]. The literature indicates a direct relationship between circulating sclerostin levels and age as well as positive correlations between sclerostin levels with trabecular density, number and thickness in both genders, but also gender differences in bone-specific serum values with regard to possible differences in the pathogenesis of idiopathic osteoporosis [28,29].…”

Section: Discussionmentioning

confidence: 99%

TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures

Muschitz

Kocijan

Haschka

et al. 2015

Bone

131

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Section: Discussionmentioning

confidence: 99%

TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures

Muschitz

Kocijan

Haschka

et al. 2015

Bone

131

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“…In this pilot study, we mainly studied those parameters representing cancellous bone to reflect earlier bone degeneration than BMD after OT intervention. Thus, micro-CT can effectively evaluate both bone quantity and bone quality of osteoporosis at early stage by BMD and microstructural parameters reflecting cancellous bone [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Bone microarchitectural parameters can detect oxytocin induced changes prior to bone density on mitigating bone deterioration in rabbit osteoporosis model using micro-CT

Qiu

Tang

Serrano‐Sosa

et al. 2019

BMC Musculoskelet Disord

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BackgroundThis study is aimed to determine the efficacy of X-Ray Microtomography (micro-CT) in predicting oxytocin (OT) treatment response in rabbit osteoporosis(OP) model.MethodsSixty-five rabbits were randomly divided into three groups: control group, ovariectomy (OVX) -vehicle and OVX-oxytocin group. The controls underwent sham surgery. OVX-vehicle and OVX-oxytocin groups were subjected to bilateral OVX. The rabbits in OVX-oxytocin group were injected with oxytocin. In the 0th, 4th, 8th, 10th and 12th weeks post OVX operation, bone mineral density (BMD) and bone micro-architectural parameters were measured in three groups.ResultsBone mineral density (BMD), bone volume fraction (BV/TV), Trabecular Number (Tb.N), and Trabecular Thickness (Tb.Th) decreased, while Trabecular Spacing (Tb.Sp) and Structure Model Index (SMI) increased overtime in all the three groups. In OVX-oxytocin group, the bone deterioration tendency is slowing down compared with that of the OVX-vehicle group. The BMD of the OVX-oxytocin group was significantly lower than those in the OVX-vehicle group at 12th week (P = 0.017). BV/TV and Tb.Sp in OVX-oxytocin group changed significantly from 8th week (P = 0.043) and 12th week (P = 0.014), which is earlier than that of BMD and other bone micro-architectural parameters.ConclusionBV/TV and Tb.Sp changed prior to BMD and other bone micro-architectural parameters with oxytocin intervention, which indicate that they are more sensitive markers for predicting early osteoporosis and treatment monitoring when using micro-CT to evaluate osteoporosis rabbit model.

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“…N.B. Bauer et al [2] в эксперименте на крысах с моделью опухоли показали, что на первых этапах формирования остеопороза в крови возрастает содержание остеокальцина, тогда как более поздние стадии патологического процесса в кости сопровождаются увеличением концентрации остеопонтина. Следует подчеркнуть, что рак легкого закономерно протекает с повышенным уровнем в крови остеопонтина [28].…”

Section: костный метаболизм и остеопороз в онкологической практике удunclassified

Костный Метаболизм И Остеопороз В онкологической Практике

Dumanskyi

Stoliarova

Syniachenko

et al. 2022

PJS

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Представлены обзор современной литературы и собственные данные результатов исследования, в которых показано существование тесной связи злокачественных опухолей с нарушениями костного метаболизма, что проявляется увеличением синтеза остеопонтина и остеокальцина, активацией щелочной фосфатазы, дисбалансом остеоассоциированных макро- (кальций, магний, фосфор) и микроэлементов (кобальт, марганец, медь, стронций, хром, цинк и др.), участвующих в патогенетических построениях рака и остеопороза, который может осложняться у таких больных переломами костей. Изменения костного метаболизма усугубляются проводимой химио- и лучевой терапией рака, а существовавшие сведения по онкоиндуцированному действию бисфосфонатов, широко применяемых в лечении остеопороза, в настоящее время поставлены под сомнение. Перечисленные данные диктуют необходимость разработки медицинской технологии противоопухолевой терапии, обладающей протекторным действием в отношении метаболизма кости, а также создания антиостеопоротического лечения, одновременно направленного на опухолевый процесс.

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Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis

Cited by 12 publications

References 51 publications

TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures

TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures

Bone microarchitectural parameters can detect oxytocin induced changes prior to bone density on mitigating bone deterioration in rabbit osteoporosis model using micro-CT

Костный Метаболизм И Остеопороз В онкологической Практике

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