2021
DOI: 10.1002/jev2.12089
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Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease

Abstract: Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer's disease (AD). Substantial progress has been made in identifying positron emission tomography and cerebrospinal fluid biomarkers for AD, but they have limited use as front-line diagnostic tools. Extracellular vesicles (EVs) are released by all cells and contain a subset of their parental cell composition, including lipids. EVs are released from the brain into the periphery, providing a potential source of tissue and disease sp… Show more

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Cited by 93 publications
(98 citation statements)
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“…One likely acyl chain configuration for PS40:6 and PA40:6 is sn-1 18:0, sn-2 22:6. These data echo the previously described DHA decrease in the bulk preparations of human AD brain EVs and global AD-related brain DHA deficiency, which has a proinflammatory effect and may also disrupt Aβ clearance (H. Su, et al, 2021 ). The selective loss of DHA among PA and PS ( Figures 4E,F ) as well as the trend in PE ( Figure 2B ) suggests the overactivation of DHA-selective phospholipase A 2 (PLA2) and a deficit in acyl chain remodeling ( Abdullah, et al, 2017 ; Calon, et al, 2004 ; Fernandez, et al, 2018 ; Fernandez, et al, 2021 ; Fonteh, et al, 2013 ; Granger, et al, 2019 ).…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…One likely acyl chain configuration for PS40:6 and PA40:6 is sn-1 18:0, sn-2 22:6. These data echo the previously described DHA decrease in the bulk preparations of human AD brain EVs and global AD-related brain DHA deficiency, which has a proinflammatory effect and may also disrupt Aβ clearance (H. Su, et al, 2021 ). The selective loss of DHA among PA and PS ( Figures 4E,F ) as well as the trend in PE ( Figure 2B ) suggests the overactivation of DHA-selective phospholipase A 2 (PLA2) and a deficit in acyl chain remodeling ( Abdullah, et al, 2017 ; Calon, et al, 2004 ; Fernandez, et al, 2018 ; Fernandez, et al, 2021 ; Fonteh, et al, 2013 ; Granger, et al, 2019 ).…”
Section: Discussionsupporting
confidence: 89%
“…Changes in the brain EV proteome in human AD cases and animal models suggest the enrichment of a neurodegenerative microglial signature in bulk brain EV preparations ( Muraoka, et al, 2020 ; Muraoka, et al, 2021 ). Our knowledge of the miRNA transcriptome and lipidome of AD brain-derived EVs is even more limited ( Cheng, et al, 2020 ; Su, et al, 2021 ). Here we specifically focus on human microglia-derived EVs isolated from cryopreserved human tissue from late AD (Braak V-VI) and normal/low pathology (NL) cases in order to characterize their molecular profiles utilizing an integrative approach combining proteomic, transcriptomic (miRNA), and lipidomic analyses.…”
Section: Introductionmentioning
confidence: 99%
“…Synaptic proteins, inflammatory mediators, growth factors and lysosomal proteins also presented distinct expression patterns in exosomes from AD cases when compared to Controls [ 16 19 ]. In addition, specific microRNA [ 12 , 20 , 21 ], metabolic [ 22 ], or lipid profile [ 23 ] alterations have been reported.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, EVs lipidomes’ characterization is valuable in evaluating lipid dysregulations associated to various diseases. For instance, Su et al investigated the lipidomic profile of brain-derived EVs (BDEVs) in human frontal cortex to determine a potential altered lipid pattern in Alzheimer’s disease [ 100 ]. The other encouraging application of lipidomics is the research of EVs lipid biomarkers.…”
Section: Extracellular Vesicle As Resourceful Biological Systemsmentioning
confidence: 99%