Characterization of C-reactive protein in dogs undergoing medial patellar luxation surgery

Jervan, Marte; Szlosek, Donald; Friis, Hanne; Coyne, Michael J.; DeNicola, Dennis B.; Johnsen, Ole Harald

doi:10.1371/journal.pone.0231445

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…The present study was conducted on dogs considered healthy by clinical and laboratory tests, including complete blood counts and serum biochemistry profiles. Among the orthopedic diseases, MPL and CCLR were included in the orthopedic group because most of these diseases were chronic and generally not accompanied by elevated pre-operative CRP levels [14].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies of CRP in dogs showed similar results compared to human medicine [11,12]. A previous study that compared the factors participating in the acute-phase response in dogs undergoing elective general surgery (GS) revealed that CRP was a more reliable parameter than white blood cell (WBC) counts [13][14][15]. It also reflects the degree of surgical stress or the current status of dogs with acute or chronic diseases [16][17][18][19].…”

Section: Introductionmentioning

confidence: 86%

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Comparison of post-operative C-reactive protein levels between elective general and orthopedic surgery in dogs

Sung¹,

Kim²,

Won-Hyung³

et al. 2021

J Biomed Transl Res

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C-reactive protein (CRP) is an acute-phase protein produced by hepatocytes. The plasma concentration of CRP peaks around 48 hours following stimulation. A rapid decrease in CRP levels is observed when the stimuli end. Considering these characteristics of CRP, it is used to evaluate acute inflammatory responses in clinics. In addition, as it reflects the degree of surgical trauma, measuring the CRP concentration is an effective method of evaluating tissue damage depending upon the surgical method. As CRP is also an acute-phase protein in dogs, the purpose of the present study was to compare the factors related to acute inflammatory responses between dogs undergoing elective general surgery (GS) and orthopedic surgery (OS). A total of 44 healthy dogs were included in this study. The sex ratio of dogs that underwent OS was similar. Both groups showed increased CRP levels and white blood cell (WBC) counts on post-operative day (POD) 1-2. The CRP level in the OS group on POD 1-2 was significantly higher than that of the GS group and it was increased about 16-fold compared to the pre-operative value. No significant difference in WBC counts was observed between the two groups. Although a slight increase in the WBC count was observed on POD 1-2 in both groups, it was near the reference range during follow-up. Thus, measuring CRP levels can be more effective in evaluating acute inflammatory responses than WBC counts. Although a high level of post-operative serum CRP concentrations was observed in the OS group, it rapidly decreased to a level similar to the pre-operative value if there were no post-operative complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

Comparison of post-operative C-reactive protein levels between elective general and orthopedic surgery in dogs

Sung¹,

Kim²,

Won-Hyung³

et al. 2021

J Biomed Transl Res

View full text Add to dashboard Cite

show abstract

“…Patellar luxation often requires surgery but does not cause severe trauma or inflammation by itself, as otherwise healthy dogs expecting surgery showed physiological CRP concentrations. Twenty-four hours after the surgery a 2–6-fold rise (median 92 μg/mL) was noted [ 86 ]. CRP may be a nonspecific biomarker for discospondylitis—but probably more sensitive than fever, leukocytosis, neutrophilia, and hyperglobulinemia.…”

Section: Orthopedic Diseasesmentioning

confidence: 99%

C-Reactive Protein as a Diagnostic Marker in Dogs: A Review

Malin

2022

Animals

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Acute phase response is a nonspecific reaction to disturbances in homeostasis during which the production of some Acute Phase Proteins (APPs) is stimulated; they are sensitive but nonspecific markers of systemic inflammatory processes. The major positive APP in dogs is the C-reactive protein (CRP). The dynamic of its concentration changes fast, rising and decreasing rapidly with the onset and removal of the inflammatory stimulus. It increases within the first 4–24 h after the stimulus and reaches up to a 50–100-fold increase of the baseline level. It has been documented that this APP’s concentration is elevated during several diseases, such as pyometra, panniculitis, acute pancreatitis, polyarthritis, sepsis, immune-mediated hemolytic anemia, and neoplasia in dogs. In clinical practice, canine CRP is mostly measured to detect and monitor systemic inflammatory activity and the efficacy of treatments, because it is a more sensitive marker than shifts in leukocyte counts. Blood serum CRP concentration is becoming a part of routine biochemistry panels in many countries. In this article, changes in CRP concentration and its clinical application in healthy and diseased dogs are discussed.

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“…Thus, this particular assay was found to be sufficiently accurate and precise for clinical use. One study which served as a clinical validation of the Catalyst CRP assay found that it could reliably differentiate between the CRP concentrations of dogs that were pre‐ and postmedial patellar luxation surgery 33 …”

Section: Measurement Of Canine Crpmentioning

confidence: 99%

Measurement and clinical applications of C‐reactive protein in gastrointestinal diseases of dogs

Covin

Steiner

2022

Veterinary Clinical Pathol

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C‐reactive protein (CRP) is a positive acute‐phase protein, serum concentrations of which increase nonspecifically in response to inflammatory processes of the dog. As such, it can aid in the identification of inflammatory disease and, maybe more importantly, the objective monitoring of disease progression. In dogs, CRP is frequently used to evaluate dogs with gastrointestinal diseases, such as chronic inflammatory enteropathies (also termed idiopathic inflammatory bowel disease), acute pancreatitis, canine parvovirus infection, hepatic disease, acute abdomen, and protein‐losing enteropathy. The diversity of the assays available to measure CRP in dogs is nearly as numerous as the diseases in which serum concentrations of this protein are increased. Assay methodologies include laser nephelometric immunoassays, enzyme‐linked immunosorbent assays, immunoturbidimetric assays, and time‐resolved immunofluorometric assays. While many of these assays are acceptable for clinical use in the dog, the same assay and analyzer should be used to measure a patient's CRP concentration longitudinally. By looking at the uses of CRP in human gastroenterology, including reducing the duration of antibiotic therapy, the veterinary profession can gain insight into novel ways in which serum CRP concentration measurements might be applied in veterinary medicine in the future.

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Characterization of C-reactive protein in dogs undergoing medial patellar luxation surgery

Cited by 5 publications

References 9 publications

Comparison of post-operative C-reactive protein levels between elective general and orthopedic surgery in dogs

Comparison of post-operative C-reactive protein levels between elective general and orthopedic surgery in dogs

C-Reactive Protein as a Diagnostic Marker in Dogs: A Review

Measurement and clinical applications of C‐reactive protein in gastrointestinal diseases of dogs

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