Characterization of calcium phosphate cements modified by addition of amorphous calcium phosphate

Vreken, Natasja Van den; Pieters, Ilse Y.; Declercq, Heidi; Cornelissen, Maria; Verbeeck, Ronald

doi:10.1016/j.actbio.2009.07.038

Cited by 44 publications

(30 citation statements)

References 49 publications

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“…The reason of this phenomenon is not clear yet; but, perhaps, it correlates with similar results for β-TCP granules, which act as bone anchors and encourage formation of a mature bone [266,267]. Other ACP-containing formulations were elaborated as well [525]. …”

Section: Reinforced Formulations and Concretesmentioning

confidence: 78%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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Section: Reinforced Formulations and Concretesmentioning

confidence: 78%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

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“…EDS spectrum confirmed that the surface of CSiC cement was covered by a layer rich in calcium (Ca) and phosphorous (P). The signal of the magnesium (Mg) in the EDS spectrum can be related with the formation of a calcium deficient apatite (Ca 9 HPO 4 (PO 4 ) 5 OH‐CDHA), where the magnesium ions (Mg 2+ ) can occupy some Ca 2+ sites in the crystalline network . Also silicon (Si) sign was detected as consequence of C‐S‐H formation.…”

Section: Resultsmentioning

confidence: 99%

β‐Dicalcium silicate‐based cement: Synthesis, characterization and in vitro bioactivity and biocompatibility studies

Corrêa

Almirall

Carrodeguas

et al. 2013

J Biomedical Materials Res

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β-dicalcium silicate (β-Ca₂ SiO₄, β-C₂ S) is one of the main constituents in Portland cement clinker and many refractory materials, itself is a hydraulic cement that reacts with water or aqueous solution at room/body temperature to form a hydrated phase (C-S-H), which provides mechanical strength to the end product. In the present investigation, β-C₂ S was synthesized by sol-gel process and it was used as powder to cement preparation, named CSiC. In vitro bioactivity and biocompatibility studies were assessed by soaking the cement samples in simulated body fluid solutions and human osteoblast cell cultures for various time periods, respectively. The results showed that the sol-gel process is an available synthesis method in order to obtain a pure powder of β-C₂ S at relatively low temperatures without chemical stabilizers. A bone-like apatite layer covered the material surface after soaking in SBF and its compressive strength (CSiC cement) was comparable with that of the human trabecular bone. The extracts of this cement were not cytotoxic and the cell growth and relative cell viability were comparable to negative control.

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“…52 Finally, it is known for many cell types that proliferation declines when differentiation begins. As mentioned earlier, the CaP formed by ALP may release Ca 2þ ions, resulting in concentrations toxic to cells, particularly if soluble, noncrystalline CaP phases are present.…”

Section: Discussionmentioning

confidence: 99%

Enzymatically induced mineralization of platelet‐rich fibrin

Douglas

Gaßling

Declercq

et al. 2012

J Biomedical Materials Res

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Membranes of the autologous blood‐derived biomaterial platelet‐rich fibrin (PRF) were functionalized by incorporation of alkaline phosphatase (ALP), an enzyme involved in mineralization of bone, and subsequently incubated in calcium glycerophosphate (CaGP) solution to induce PRFs mineralization with calcium phosphate (CaP) to improve PRFs suitability as a material for bone replacement. Incorporated ALP retained its bioactivity and induced formation of CaP material within PRF membranes, as confirmed by SEM, EDS, FTIR, and von Kossa staining. The mass percentage attributable to CaP was quantified by lyophilization and measurement of the remaining mass fraction as well as by TGA. Cytocompatibility tests (LDH, MTT, and WST) with SAOS‐2 cells showed that mineralized PRF did not release substances detrimental to cell vitality. Live/dead staining and SEM showed that mineralized PRF was colonized by cells. The results show that hydrogel biomaterials such as PRF can be mineralized through functionalization with ALP. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2012.

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Characterization of calcium phosphate cements modified by addition of amorphous calcium phosphate

Cited by 44 publications

References 49 publications

Self-Setting Calcium Orthophosphate Formulations

Self-Setting Calcium Orthophosphate Formulations

β‐Dicalcium silicate‐based cement: Synthesis, characterization and in vitro bioactivity and biocompatibility studies

Enzymatically induced mineralization of platelet‐rich fibrin

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