Characterization of cerebral blood flow dynamics with multiscale entropy

Abstract

Based on the laser speckle contrast imaging (LSCI) and the multiscale entropy (MSE), we study in this work the blood°ow dynamics at the levels of cerebral veins and the surrounding network of microcerebral vessels. We discuss how the phenylephrine-related acute peripheral hypertension is re°ected in the cerebral circulation and show that the observed changes are scale-dependent, and they are signi¯cantly more pronounced in microcerebral vessels, while the macrocerebral dynamics does not demonstrate authentic inter-group distinctions. We also consider the permeability of blood-brain barrier (BBB) and study its opening caused by sound exposure. We show that alterations associated with the BBB opening can be revealed by the analysis of blood°ow at the level of macrocerebral vessels.

Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood–brain barrier leakage

“…During this sound exposure, rats stayed in Plexiglas sound isolated chamber and the second ECoG was recorded immediately after the sound stimulation during 1 h (ECoG2). It is assumed 27 , 28 that the abovementioned sound stimulation can lead to increased permeability of the BBB for 30–60 min. Two days after sound exposition, the third ECoG was recorded during 1–1.5 h (ECoG3).…”