2024
DOI: 10.1021/acs.est.4c04356
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Characterization of Chemical Exposome in A Paired Human Preconception Pilot Study

Jaye Marchiandi,
Sonia Dagnino,
Deirdre Zander-Fox
et al.

Abstract: Parental preconception exposure to synthetic chemicals may have critical influences on fertility and reproduction. Here, we present a robust LC−MS/MS method covering up to 95 diverse xenobiotics in human urine, serum, seminal and follicular fluids to support exposome-wide assessment in reproductive health outcomes. Extraction recoveries of validated analytes ranged from 62% to 137% and limits of quantification from 0.01 to 6.0 ng/mL in all biofluids. We applied the validated method to a preconception cohort of… Show more

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