Characterization of chitin–metal silicates as binding superdisintegrants

A novel multifunctional pharmaceutical excipient: Modification of the permeability of starch by processing with magnesium silicate

“…Incorporation of Mg silicate with defined pharmaceutical excipients, has beneficially resulted in compacts of high mechanical strength, that possess good compressibility characteristics and short disintegration times (Rashid et al, 2009) as well as low sensitivity towards lubrication (Rashid et al, 2010). Thus Mg silicate/starch preparations have the potential to fulfill the requirements of a multifunctional excipient.…”

“…Recently, progress in developing new excipients with multifunctional capabilities (as glidants, fillers, binders, and disintegrants) has exploited the use of magnesium silicate produced synthetically by co-precipitation (Rashid et al, 2009;Badwan et al, 2007). Incorporation of Mg silicate with defined pharmaceutical excipients, has beneficially resulted in compacts of high mechanical strength, that possess good compressibility characteristics and short disintegration times (Rashid et al, 2009) as well as low sensitivity towards lubrication (Rashid et al, 2010).…”

Evaluation of Three Chitin Metal Silicate Co-Precipitates as a Potential Multifunctional Single Excipient in Tablet Formulations

“…These insoluble metal silicates were deposited on a chitin surface as reported earlier [12]. The pH of the media of the co-precipitation of calcium, magnesium, and aluminum silicates on chitin particles was measured as 10, 9, and 4, respectively.…”

“…Recently, Rashid et al [12] prepared and characterized three co precipitates of metal silicates ( i.e. , calcium, magnesium, and aluminum) onto chitin particles, which can be compressed into rapid disintegrating compacts.…”

Application of N-hexoyl chitosan derivatives with high degree of substitution in the preparation of super-disintegrating pharmaceutical matrices

“…For example, in order to improve the mecahnical properties of CS, it was co-processed with other inorganic materials such as silica or metal silicates [10]. The resultant co-excipient was found to have much higher compressibility and disintegrating power than CS itself [24,27,53,54]. Furthermore, in order to enhance CS controlled release activity, it was mixed with other polymers such as sodium alginate [8,28], xanthan gum [4,23], hydroxyethyl cellulose [7], carrageenan [40], and guar gum [9].…”