Characterization of Chronic Fatigue in Patients With Sarcoidosis in Clinical Remission

Korenromp, Ingrid H.E.; Heijnen, Cobi J.; Vogels, O.J.M.; Bosch, Jules M.M. van den; Grutters, Jan C.

doi:10.1378/chest.10-2629

Cited by 96 publications

(88 citation statements)

References 30 publications

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“…In sarcoidosis, fatigue may be intensified by acute stage of the disease, obesity, or glucocorticoid use [20]. Sleep apnoea may also have some influence on fatigue sensation.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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Fatigue in patients with inactive sarcoidosis does not correlate with lung ventilation ability or walking distance. Pilot StudyZmęczenie u chorych z nieaktywną sarkoidozą nie koreluje ze zdolnością wentylacyjną płuc oraz z dystansem chodu. Badanie pilotażoweThe work has been conducted under a grant from the Silesian Medical University: project No. KNW-1-025/D/2/0 Abstract Introduction: Fatigue is one of many symptoms reported by patients with sarcoidosis. It is believed that fatigue may be the cause of exercise intolerance and reduced quality of life in patients with sarcoidosis. The purpose of the work was to present the frequency of fatigue prevalence in patients with sarcoidosis and to investigate the correlation between fatigue and the results of pulmonary function tests and walking distance. Material and methods: A total of 74 patients with sarcoidosis in a stable phase of the disease, not treated in the past with glucocorticoids or immunosuppressive drugs, and without indications for treatment at the time of the study were examined. In all patients fatigue evaluation was carried out with the use of the Fatigue Assessment Scale questionnaire (FAS); dyspnoea was assessed with the use of the Medical Research Council scale (MRC). Body Mass Index (BMI), spirometry, and a 6-minute walk test were additionally performed. The control group included 30 healthy volunteers who completed the FAS. Results: In the examined group of patients fatigue was diagnosed in 36 patients (50%), and in 5 (6.94%) -strong fatigue was observed. The remaining 31 (43.06%) patients felt no fatigue. The average value of points obtained by FAS questionnaire in sarcoidosis patients was significantly higher than the respective value in the control group (p = 0.02). A significantly higher number of points by FAS questionnaire was observed in female patients with sarcoidosis (p = 0.04) in comparison to men. No significant statistical correlation between fatigue index FAS and BMI (r = 0.22, p = 0.11), FEV 1 (r = -0.11, p = 0.3), FEV 1 % pred. (r = 0.01, p = 0.9), FVC (r = −0.03, p = 0.77), FEF 25−75 (r = −0.23, p = 0.1) and the distance in the six-minute walk test (6MWT) (r = −0.01, p = 0.9) was observed. However, there was a weak negative correlation between the age of the patients and the FAS index (r = −0.29, p = 0.01). Conclusions: Fatigue in patients with sarcoidosis does not correlate with the results of lung function tests or with walking distance in 6MWT.

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“…In sarcoidosis, fatigue may be intensified by acute stage of the disease, obesity, or glucocorticoid use [20]. Sleep apnoea may also have some influence on fatigue sensation.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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“…Fatigue is the most frequently described and disabling symptom in sarcoidosis and can be nonspecific and difficult to characterize for both patients and clinicians [20,36]. Sarcoidosis-associated fatigue and exercise capacity have important associations with QoL, especially in the domain of physical health [17,[37][38][39][40].…”

Section: Fatigue and Dyspneamentioning

confidence: 99%

“…Sarcoidosis-related complaints, including fatigue, may become chronic and affect patients' QoL even after all other signs of disease activity have disappeared; this appears to be unique to sarcoidosis-related fatigue as compared to other inflammatory conditions [36,71]. Physicians generally assess disease severity and progression in sarcoidosis on the basis of socalled 'objective measures' such as pulmonary function tests, chest radiographs, and serologic tests.…”

Section: Quality Of Lifementioning

confidence: 99%

Physical activity and training in sarcoidosis: review and experience-based recommendations

Strookappe

Saketkoo

Elfferich

et al. 2016

Expert Review of Respiratory Medicine

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“…In active disease several factors should be considered, for instance systemic inflammation, muscle involvement, extrapulmonary locations, comorbidities, pulmonary hypertension, impaired lung function, steroids and other drugs used for the treatment of sarcoidosis, and psychological factors [10]. The pathogenesis of PSFS is even more mysterious [11,12]. Depression and anxiety is frequent in patients with active sarcoidosis [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Utility of Selected Questionnaires in the Assessment of Fatigue, Depression and Health Quality in Post-Sarcoidosis Fatigue Syndrome

Górski

Mokros

Kumor-Kisielewska

et al. 2017

Advances in Respiratory Medicine

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Introduction: The nature of post-sarcoidosis fatigue syndrome (PSFS) is unknown and tools for the assessment of health quality (HQ) in these patients have not been fully assessed. The aim was to validate the Polish version of sarcoidosis health questionnaire (SHQ) and verify the association of HQ with fatigue and depressive symptoms among Polish patients with PSFS. Material and methods: 71 patients with sarcoidosis (34 women, the mean age 47) were divided to: PSFS (n = 21), active sarcoidosis (S-A, n = 27) and sarcoidosis with complete remission (S-R, n = 23) groups. Fatigue Assessment Scale (FAS) was used to define significant fatigue (≥ 22 points). Polish version of SHQ was prepared by the authors and validated. Beck Depression Index (BDI) and Patient Health Questionnaire 9 (PHQ-9) were used to evaluate self-reported depressive symptoms. Results: Polish version of SHQ was proved reliable and valid. HQ was worse and depressive symptoms were more frequent in PSFS and S-A when compared with S-R group. SHQ total score correlated negatively with depressive symptoms (r = -0.787 for BDI and r = -0,755 for PHQ-9, p < 0.01). A negative correlation between SHQ and FAS score was found (r = -0.784, p < 0.01). FAS score correlated with depressive symptoms (r = 0.726 for BDI and r = 0.755 for PHQ-9, p < 0.01). Conclusion: Polish version of SHQ is a valuable tool for the assessment of HQ in sarcoidosis. HQ is impaired in PSFS comparing to patients with complete remission, but is comparable to active sarcoidosis. Depressive symptoms impact HQ and may influence perception of fatigue. Both fatigue and depression have a negative impact on HQ in sarcoidosis.

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Characterization of Chronic Fatigue in Patients With Sarcoidosis in Clinical Remission

Cited by 96 publications

References 30 publications

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Physical activity and training in sarcoidosis: review and experience-based recommendations

The Utility of Selected Questionnaires in the Assessment of Fatigue, Depression and Health Quality in Post-Sarcoidosis Fatigue Syndrome

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