Characterization of Clinical Blood Isolates of<i>Streptococcus agalactiae</i>with Reduced Susceptibility to Levofloxacin

Llaneza, E.; Seral, Cristina; Castillo, Francisca; Durán, Estrella Montolío; Rubio-Calvo, C.; Gómez-Lus, R

doi:10.1179/joc.2009.21.4.463

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“…These data are consistent with previously published data on S. agalactiae strains from human origins in other countries (De Mouy et al 2001, Ferjani et al 2006, Gherardi et al 2007, Savoia et al 2008, including Brazil (Duarte et al 2005, Oliveira et al 2005, Palmeiro et al 2010. Although strains resistant to penicillin and levofloxacin have been described, they remain rare (Kimura et al 2008, Llaneza et al 2009, Nakamura et al 2011).…”

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confidence: 91%

The genetic diversity and phenotypic characterisation of Streptococcus agalactiae isolates from Rio de Janeiro, Brazil

Corrêa

Silva

Pinto

et al. 2011

Mem. Inst. Oswaldo Cruz

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Streptococcus agalactiae isolates are more common among pregnant women, neonates and nonpregnant adults with underlying diseases compared to other demographic groups. In this study, we evaluate the genetic and phenotypic diversity in S. agalactiae strains from Rio de Janeiro (RJ) that were isolated from asymptomatic carriers. We analysed these S. agalactiae strains using pulsed-field gel electrophoresis (PFGE), serotyping and antimicrobial susceptibility testing, as well as by determining the macrolide resistance phenotype, and detecting the presence of the ermA/B, mefA/E and lnuB genes. The serotypes Ia, II, III and V were the most prevalent serotypes observed. The 60 strains analysed were susceptible to penicillin, vancomycin and levofloxacin. Resistance to clindamycin, chloramphenicol, erythromycin, rifampin and tetracycline was observed. Among the erythromycin and/or clindamycin resistant strains, the ermA, ermB and mefA/E genes were detected and the constitutive macrolides, lincosamides and streptogramin B-type resistance was the most prevalent phenotype observed. The lnuB gene was not detected in any of the strains studied. We found 56 PFGE electrophoretic profiles and only 22 of them were allocated in polymorphism patterns. This work presents data on the genetic diversity and prevalent capsular serotypes among RJ isolates. Approximately 85% of these strains came from pregnant women; therefore, these data may be helpful in developing future prophylaxis and treatment strategies for neonatal syndromes in RJ.

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