“…Glycopeptides have traditionally been considered as the drug of choice in the treatment of infections caused by these organisms. Since the first report of teicoplainin resistance in methicillin-resistance CNS in the USA and UK, the emergence of glycopeptides-resistant CNS in patients treated for long period with vancomycin has been increasingly documented (Aritaka et al, 1997;Smith et al, 1999;Natoli et al, 2009 (Cunnigngham, 1993;Obi et al, 2003). In Limpopo Province, Peltophorum africanum, Carissa edulis, Securidaca spp.…”