Characterization of Conductivity Changes During High-Frequency Irreversible Electroporation for Treatment Planning

Zhao, Yajun; Bhonsle, Suyashree; Dong, Shoulong; Lv, Yanpeng; Li, Hongmei; Safaai‐Jazi, A.; Davalos, Rafael V.; Yao, Chenguo

doi:10.1109/tbme.2017.2778101

Cited by 60 publications

(35 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prior to the onset of electroporation, the high frequency waveforms of H-FIRE penetrate to the intracellular domain more efficiently than their low frequency counterparts used in IRE; this phenomenon has been exploited to target cells with enlarged nuclei, a physical hallmark common in malignant cells, and resulted in lower lethal EFTs in tumor cells [37,38]. More promising still, these higher frequency waveforms mitigate electrical heterogeneities in complex tissues, resulting in more predictable ablations in highly heterogenous tissues such as tumor tissue [39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation

Lorenzo

Thomas

Kani

et al. 2019

Cancers

Self Cite

View full text Add to dashboard Cite

Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood–brain barrier (BBB). Electroporation-based therapies have demonstrated the capability of permeating the BBB, but knowledge of the longevity of BBB disruption (BBBD) is limited. In this study, we quantify the temporal, high-frequency electroporation (HFE)-mediated BBBD in an in vivo healthy rat brain model. 40 male Fisher rats underwent HFE treatment; two blunt tipped monopolar electrodes were advanced into the brain and 200 bursts of HFE were delivered at a voltage-to-distance ratio of 600 V/cm. BBBD was verified with contrast enhanced T1W MRI (gadopentetate dimeglumine) and pathologically (Evans blue dye) at time points of 1, 24, 48, 72, and 96 h after HFE. Contrast enhanced T1W scans demonstrated BBBD for 1 to 72 h after HFE but intact BBB at 96 h. Histologically, tissue damage was restricted to electrode insertion tracks. BBBD was induced with minimal muscle contractions and minimal cell death attributed to HFE. Numerical modeling indicated that brief BBBD was induced with low magnitude electric fields, and BBBD duration increased with field strength. These data suggest the spatiotemporal characteristics of HFE-mediated BBBD may be modulated with the locally applied electric field.

show abstract

Section: Introductionmentioning

confidence: 99%

Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation

Lorenzo

Thomas

Kani

et al. 2019

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…Electric conductivity is a key parameter in the calculation of electric fields. Previous studies demonstrated that electric conductivity dynamically changes from the baseline to higher values in the steps depending on EFS and the temperature [36,41,42]. An electro-thermal coupling function (Equation (4)) was introduced to calculate the electrical conductivity during IRE by Garcia et al [43].…”

Section: Discussionmentioning

confidence: 99%

“…The tissue electrical conductivity was determined using the following equation to incorporate changes due to electroporation and thermal effect [24,26,41,42]:…”

Section: Tissue Electrical Conductivitymentioning

confidence: 99%

“…In fact, A, E range and E delta are specific to the tissue of interest. These data were chosen based on values commonly found in the literature [34,41]. The conductivity-temperature coefficient ranges from 0.01 to 0.03 1/K, and a value of 0.02 1/K was selected in this study.…”

Section: Tissue Electrical Conductivitymentioning

confidence: 99%

“…where V 0 is the potential difference across the electrodes. The outer boundary of the tissue were set as electrical insulating [24,34,35,41]. The initial temperature of the tissue and artery was set to 37 C (310.15 K), which is the normal physiological body temperature.…”

Section: Boundary and Initial Conditionsmentioning

confidence: 99%

See 2 more Smart Citations

Electrical and thermal analyses of catheter-based irreversible electroporation of digestive tract

Ren

Liu

Gao

et al. 2019

International Journal of Hyperthermia

View full text Add to dashboard Cite

Introduction: Irreversible electroporation (IRE) combined with a catheter-based electrode during endoscopy is a potential alternative treatment method for digestive tract tumors. The aim of this study was to investigate the electrical injury (EI) and thermal injury (TI) to the digestive tract via numerical analyses and to evaluate the role and impact of electrode configurations and pulse settings on the efficacy and outcomes of IRE. Materials and methods: A finite element method was used to solve the numerical model. A digestive tract model having 4-mm-thick walls and two catheter-based electrode configuration models were constructed. The distributions of electric fields, temperature, electrical conductivity, tissue injury and limitation on the pulse number required for IRE were calculated and compared. Results: Electrode length is an important geometric parameter for electrodes in the monopolar model (MPM), while electrode spacing affects the outcomes in the bipolar model (BPM). Increasing the pulse voltage reduces the pulse number required for tissue ablation, while increasing the risk of TI. In total, there were 6 NT-IRE protocols, 12 thermal-IRE protocols and 30 TI protocols. All of the NT-IRE protocols were set in BPMs with a voltage of 0.50 kV. With increasing electrode spacing, the minimum pulse number decreased. However, thermal effects were inevitable in the MPM. Conclusions: The electrode configuration and pulse settings are adjusted to achieve NT-IRE synergistically. The BPM is more reliable for achieving NT-IRE in 4-mm-thick digestive wall. Future in vitro and in vivo studies are needed to support and validate this conclusion. ARTICLE HISTORY

show abstract

Global sensitivity study for irreversible electroporation: Towards treatment planning under uncertainty

et al. 2023

View full text Add to dashboard Cite

Background: Electroporation-based cancer treatments are minimally invasive, nonthermal interventional techniques that leverage cell permeabilization to ablate the target tumor. However, the amount of permeabilization is susceptible to the numerous uncertainties during treatment, such as patient-specific variations in the tissue, type of the tumor, and the resolution of imaging equipment. These uncertainties can reduce the extent of ablation in the tissue, thereby affecting the effectiveness of the treatment. Purpose: The aim of this work is to understand the effect of these treatment uncertainties on the treatment outcome for irreversible electroporation (IRE) in the case of colorectal liver metastasis (CRLM). Understanding the nature and extent of these effects can help us identify the influential treatment parameters and build better models for predicting the treatment outcome. Methods: This is an in silico study using a static computational model with a custom applicator design, spherical tissue, and tumor geometry. A nonlinear electrical conductivity, dependent on the local electric field, is considered. Morris analysis is used to identify the influential treatment parameters on the treatment outcome. Seven treatment parameters pertaining to the relative tumor location with respect to the applicator, the tumor growth pattern, and the electrical conductivity of tissue are analyzed. The treatment outcome is measured in terms of the relative tumor ablation with respect to the target ablation volume and total ablation volume. Results: The Morris analysis was performed with 800 model evaluations, sampled from the seven dimensional input parameter space. Electrical properties of the tissue, especially the electrical conductivity of the tumor before ablation, were found to be the most influential parameter for relative tumor ablation and total ablation volume. This parameter was found to be about 4-15 times more influential than the least influential parameter, depending on the tumor size. The tumor border configuration was identified as the least important parameter for treatment effectiveness. The most desired treatment outcome is obtained by a combination of high healthy liver conductivity and low tumor conductivity. This information can be used to tackle worst-case scenarios in treatment planning. Finally, when the safety margins used in the clinical applications are accounted for, the effects of uncertainties in the treatment parameters reduce drastically. Conclusions:The results of this work can be used to create an efficient surrogate estimator for uncertainty quantification in the treatmentThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

show abstract

Characterization of Conductivity Changes During High-Frequency Irreversible Electroporation for Treatment Planning

Abstract: The treatment planning method developed in this study can be translated to H-FIRE treatments of different widths and for different tissue types.

Cited by 60 publications

References 38 publications

Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation

Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation

Electrical and thermal analyses of catheter-based irreversible electroporation of digestive tract

Global sensitivity study for irreversible electroporation: Towards treatment planning under uncertainty

Contact Info

Product

Resources

About