Characterization of core/shell Cu/Ag nanopowders synthesized by electrochemistry and assessment of their impact on hemolysis, platelet aggregation, and coagulation on human blood for potential wound dressing use

Laloy, Julie; Haguet, Hélène; Alpan, Lütfiye; Mancier, Valérie; Mejia, Jorge; Levi, Samuel; Dogné, Jean Michel; Lucas, Stéphane; Rousse, Céline; Fricoteaux, Patrick

doi:10.1007/s11051-017-3937-0

Cited by 1 publication

(3 citation statements)

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“…Therefore, it can be concluded that synthesized Cu 2 O NPw does not affect platelet aggregation in these conditions. These results are in line with our previously published work [ 44 ]. This absence of toxic effects on platelets can be explained by the anionic surface of cuprite sonoelectrochemical NPcs, the zeta potential value previously determined in water being equal to −13 mV [ 13 ].…”

Section: Resultssupporting

confidence: 94%

“…It is noticeable that the results of this work are analogous to previous published work reporting the assessment of the impact of copper sonoelectrochemical NPcs using the same methodology, which indicates similar results (a decreased lagtime and an increased peak concentration of thrombin) [ 44 ].…”

Section: Resultssupporting

confidence: 86%

“…Hemolysis was assessed as previously described [ 44 ] using the blood of 3 healthy donors. NPw is suspended in water to assay final concentrations ranging from 0.1 to 500 µg/mL.…”

Section: Methodsmentioning

confidence: 99%

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Antifungal and Coagulation Properties of a Copper (I) Oxide Nanopowder Produced by Out-of-Phase Pulsed Sonoelectrochemistry

Mancier,

Fattoum,

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et al. 2024

Antibiotics

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Copper (I) oxide (cuprite) is a material widely used nowadays, and its versatility is further amplified when it is brought to the nanometric size. Among the possible applications of this nanomaterial, one of the most interesting is that in the medical field. This paper presents a cuprite nanopowder study with the aim of employing it in medical applications. With regards to the environmental context, the synthesis used is related to green chemistry since the technique (out-of-phase pulsed electrochemistry) uses few chemical products via electricity consumption and soft conditions of temperature and pressure. After different physico-chemical characterizations, the nanopowder was tested on the Candida albicans to determine its fungicide activity and on human blood to estimate its hemocompatibility. The results show that 2 mg of this nanopowder diluted in 30 µL Sabouraud broth was able to react with Candida albicans. The hemocompatibility tests indicate that for 25 to 100 µg/mL of nanopowder in an aqueous medium, the powder was not toxic for human blood (no hemolysis nor platelet aggregation) but promoted blood coagulation. It appears, therefore, as a potential candidate for the functionalization of matrices for medical applications (wound dressing or operating field, for example).

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Section: Resultssupporting

confidence: 94%

Section: Resultssupporting

confidence: 86%